Carbazochrome salicylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591131

CAS#: 13051-01-9

Description: Carbazochrome salicylate is a coagulant.

Chemical Structure

Carbazochrome salicylate
CAS# 13051-01-9

Theoretical Analysis

MedKoo Cat#: 591131
Name: Carbazochrome salicylate
CAS#: 13051-01-9
Chemical Formula: C17H17N4NaO6
Exact Mass: 396.1046
Molecular Weight: 396.33
Elemental Analysis: C, 51.52; H, 4.32; N, 14.14; Na, 5.80; O, 24.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Carbazochrome salicylate; Andenogen

IUPAC/Chemical Name: Salicylic acid, monosodium salt, compd. with 3-hydroxy-1-methyl-5,6-indolinedione 5-semicarbazone (1:1)


InChi Code: InChI=1S/C10H12N4O3.C7H6O3.Na/c1-14-4-9(16)5-2-6(12-13-10(11)17)8(15)3-7(5)14;8-6-4-2-1-3-5(6)7(9)10;/h2-3,9,16H,4H2,1H3,(H3,11,13,17);1-4,8H,(H,9,10);/q;;+1/p-1/b12-6-;;

SMILES Code: OC1=CC=CC=C1C([O-])=O.O=C2/C(C=C3C(O)CN(C)C3=C2)=N\NC(N)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 396.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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1: Passali GC, De Corso E, Bastanza G, Di Gennaro L; HHT Gemelli Study Group. An old drug for a new application: carbazochrome-sodium-sulfonate in HHT. J Clin Pharmacol. 2015 May;55(5):601-2. doi: 10.1002/jcph.452. Epub 2015 Jan 16. PubMed PMID: 25644784.

2: Khattab FI, Ramadan NK, Hegazy MA, Al-Ghobashy MA, Ghoniem NS. Validated spectrophotometric methods for simultaneous determination of troxerutin and carbazochrome in dosage form. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:206-13. doi: 10.1016/j.saa.2014.12.047. Epub 2014 Dec 24. PubMed PMID: 25561299.

3: Oh-oka H, Yamada T, Noto H, Umeyama T, Kadekawa K, Ashitomi K, Nishijima S, Sugaya K. Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis. Int J Urol. 2014 Nov;21(11):1162-6. doi: 10.1111/iju.12533. Epub 2014 Jun 25. PubMed PMID: 24964194.

4: Hu X, Zheng Y, Wu G, Liu J, Zhu M, Zhou H, Zhai Y, Wu L, Shen-Tu J. Optimization of solid phase extraction clean up and validation of quantitative determination of carbazochrome sodium sulfonate in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:1-6. doi: 10.1016/j.jchromb.2014.01.014. Epub 2014 Jan 15. PubMed PMID: 24487058.

5: Miyazaki Y, Miyawaki K, Uchino T, Kagawa Y. A novel blending method for dispensing powdered medicine. Chem Pharm Bull (Tokyo). 2014;62(1):54-7. PubMed PMID: 24390492.

6: Nishijima S, Sugaya K, Kadekawa K, Ashitomi K, Ueda T, Yamamoto H. High-dose tranilast administration to rats creates interstitial cystitis-like symptoms with increased vascular permeability. Life Sci. 2013 Nov 26;93(23):897-903. doi: 10.1016/j.lfs.2013.10.010. Epub 2013 Oct 21. PubMed PMID: 24157455.

7: Nanri Y, Yakushiji Y, Yukitake M, Nakahara Y, Matsushima T, Hara H. [A case of superficial siderosis treated with intravenous and oral hemostatic drugs]. Rinsho Shinkeigaku. 2013;53(6):470-3. Japanese. PubMed PMID: 23782826.

8: Wang H, Li M, Hu J, Wang C, Xu S, Han CC. Multiple targeted drugs carrying biodegradable membrane barrier: anti-adhesion, hemostasis, and anti-infection. Biomacromolecules. 2013 Apr 8;14(4):954-61. doi: 10.1021/bm301997e. Epub 2013 Mar 12. PubMed PMID: 23448620.

9: Gan X, Liu S, Liu Z, Hu X, Cui Z, Wang Y. Determination of carbazochrome by fluorescence quenching method. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:161-6. doi: 10.1016/j.saa.2012.05.062. Epub 2012 Jun 12. PubMed PMID: 22750685.

10: Gan XJ, Liu SP, Liu ZF, Hu XL, Tian J, Xue JX. Fluorescence quenching method for the determination of carbazochrome sodium sulfonate with aromatic amino acids. Luminescence. 2013 May-Jun;28(3):265-9. doi: 10.1002/bio.2375. Epub 2012 Apr 30. PubMed PMID: 22544487.

11: Takahashi T, Kinoshita K, Fuke T, Urushihata K, Kawamata T, Yanagisawa S, Kaneko T, Washizuka S, Hanihara T, Amano N. Acute neurogenic pulmonary edema following electroconvulsive therapy: a case report. Gen Hosp Psychiatry. 2012 Nov-Dec;34(6):703.e9-703.e11. doi: 10.1016/j.genhosppsych.2012.03.004. Epub 2012 Apr 18. PubMed PMID: 22516213.

12: Harino S, Bessho K, Kida T. Prospective multicenter study of visual outcomes following three different treatments for macular edema associated with branch retinal vein occlusion: a study by the Japanese BRVO study group. Jpn J Ophthalmol. 2012 May;56(3):250-61. doi: 10.1007/s10384-012-0121-z. Epub 2012 Feb 23. PubMed PMID: 22358585.

13: Ipema HJ, Tanzi MG. Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. Ann Pharmacother. 2012 Jan;46(1):97-107. doi: 10.1345/aph.1Q383. Epub 2011 Dec 27. Review. PubMed PMID: 22202494.

14: Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A. Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. J Arthroplasty. 2012 Jan;27(1):105-8. doi: 10.1016/j.arth.2011.02.004. Epub 2011 Mar 23. PubMed PMID: 21435821.

15: Song M, Zhao H, Wang L, Yang L, Hang T, Wen A. Development and validation of a robust LC-MS-MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study. Biomed Chromatogr. 2010 Sep;24(9):990-9. doi: 10.1002/bmc.1397. PubMed PMID: 20146401.

16: Perez-Moreno CI, Couëtil LL, Pratt SM, Ochoa-Acuña HG, Raskin RE, Russell MA. Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. Can Vet J. 2009 Aug;50(8):821-7. PubMed PMID: 19881919; PubMed Central PMCID: PMC2711466.

17: Gutiérrez-Alvarez AM, Medina Silva N, Vargas Bazurto MC, Montoya Osorio S. [Treatment of hemorrhagic dengue in the pediatric population: a systematic review]. Rev Cubana Med Trop. 2006 Sep-Dec;58(3):212-8. Review. Spanish. PubMed PMID: 23424789.

18: Liu D, Ichikawa H, Cui F, Fukumori Y. Short-term delayed-release microcapsules spraycoated with acrylic terpolymers. Int J Pharm. 2006 Jan 13;307(2):300-7. Epub 2005 Nov 23. PubMed PMID: 16309860.

19: Alejandria M. Dengue fever. Clin Evid. 2005 Jun;(13):887-95. Review. PubMed PMID: 16135283.

20: Ozawa H, Abiko Y, Akimoto T. [A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs]. Yakushigaku Zasshi. 2003;38(1):93-105. Japanese. PubMed PMID: 14570069.