WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591119

CAS#: 938-55-6

Description: N(6),N(6)-Dimethyladenine is a protein kinase inhibitor.

Chemical Structure

CAS# 938-55-6

Theoretical Analysis

MedKoo Cat#: 591119
Name: N(6),N(6)-Dimethyladenine
CAS#: 938-55-6
Chemical Formula: C7H9N5
Exact Mass: 163.0858
Molecular Weight: 163.18
Elemental Analysis: C, 51.52; H, 5.56; N, 42.92

Price and Availability

Size Price Availability Quantity
250.0mg USD 250.0 2 Weeks
500.0mg USD 410.0 2 Weeks
1.0g USD 640.0 2 Weeks
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Synonym: N(6),N(6)-Dimethyladenine; NSC 401568; NSC-401568; NSC401568

IUPAC/Chemical Name: 6-Dimethylaminopurine


InChi Code: InChI=1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 163.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information

1: Kubiasová K, Mik V, Nisler J, Hönig M, Husičková A, Spíchal L, Pěkná Z, Šamajová O, Doležal K, Plíhal O, Benková E, Strnad M, Plíhalová L. Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins. Phytochemistry. 2018 Jun;150:1-11. doi: 10.1016/j.phytochem.2018.02.015. Epub 2018 Mar 7. PubMed PMID: 29524794.

2: Li XC, Guo Q, Zhu HY, Jin L, Zhang YC, Zhang GL, Xing XX, Xuan MF, Luo QR, Luo ZB, Wang JX, Cui CD, Li WX, Cui ZY, Yin XJ, Kang JD. Parthenogenetic activation and somatic cell nuclear transfer of porcine oocytes activated by an electric pulse and AZD5438 treatment. Zygote. 2017 Aug;25(4):453-461. doi: 10.1017/S0967199417000272. Epub 2017 Jul 17. PubMed PMID: 28712374.

3: Lee J, You J, Lee GS, Lee ST, Hyun SH, Lee E. Combined Treatment with Demecolcine and 6-Dimethylaminopurine during Postactivation Improves Developmental Competence of Somatic Cell Nuclear Transfer Embryos in Pigs. Anim Biotechnol. 2018 Jan 2;29(1):41-49. doi: 10.1080/10495398.2017.1294598. Epub 2017 Mar 30. PubMed PMID: 28358237.

4: Liu Y, Wang H, Lu J, Miao Y, Cao X, Zhang L, Wu X, Wu F, Ding B, Wang R, Luo M, Li W, Tan J. Rex Rabbit Somatic Cell Nuclear Transfer with In Vitro-Matured Oocytes. Cell Reprogram. 2016 Jun;18(3):187-94. doi: 10.1089/cell.2015.0086. Epub 2016 May 9. PubMed PMID: 27159389.

5: Arias ME, Sánchez R, Felmer R. Effect of anisomycin, a protein synthesis inhibitor, on the in vitro developmental potential, ploidy and embryo quality of bovine ICSI embryos. Zygote. 2016 Oct;24(5):724-32. doi: 10.1017/S0967199416000034. Epub 2016 May 3. PubMed PMID: 27140503.

6: Oliveira RJ, Mantovani MS, Pesarini JR, Mauro MO, da Silva AF, Souza TR, Ribeiro LR. 6-Dimethylaminopurine and cyclohexamide are mutagenic and alter reproductive performance and intrauterine development in vivo. Genet Mol Res. 2015 Feb 2;14(1):834-49. doi: 10.4238/2015.February.2.8. PubMed PMID: 25730023.

7: Larrondo LF, Olivares-Yañez C, Baker CL, Loros JJ, Dunlap JC. Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination. Science. 2015 Jan 30;347(6221):1257277. doi: 10.1126/science.1257277. PubMed PMID: 25635104; PubMed Central PMCID: PMC4432837.

8: Liu S, Cui K, Li HL, Sun JM, Lu XR, Shen KY, Liu QY, Shi de S. Comparison of chemical, electrical, and combined activation methods for in vitro matured porcine oocytes. In Vitro Cell Dev Biol Anim. 2015 Feb;51(2):103-12. doi: 10.1007/s11626-014-9819-1. Epub 2014 Nov 26. PubMed PMID: 25424832.

9: Oliveira RJ, Mantovani MS, Silva AF, Pesarini JR, Mauro MO, Ribeiro LR. Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo. Braz J Med Biol Res. 2014 Apr;47(4):287-98. Epub 2014 Mar 28. PubMed PMID: 24714812; PubMed Central PMCID: PMC4075292.

10: Hajian M, Kiani M, Hosseini MS, Ostadhosseini S, Forouzanfar M, Afrough M, Nasr-Esfahani MH. Specific activation requirements of zona-free sheep oocytes before and after somatic cell nuclear transfer. Cell Reprogram. 2013 Jun;15(3):247-57. doi: 10.1089/cell.2012.0089. PubMed PMID: 23713434.

11: Fernandes CB, Devito LG, Martins LR, Blanco ID, de Lima Neto JF, Tsuribe PM, Gonçalves CG, da Cruz Landim-Alvarenga F. Artificial activation of bovine and equine oocytes with cycloheximide, roscovitine, strontium, or 6-dimethylaminopurine in low or high calcium concentrations. Zygote. 2014 Aug;22(3):387-94. doi: 10.1017/S0967199412000627. Epub 2013 Jan 23. PubMed PMID: 23340077.

12: Ruggeri RR, Watanabe Y, Meirelles F, Bressan FF, Frantz N, Bos-Mikich A. The use of parthenotegenetic and IVF bovine blastocysts as a model for the creation of human embryonic stem cells under defined conditions. J Assist Reprod Genet. 2012 Oct;29(10):1039-43. doi: 10.1007/s10815-012-9866-z. Epub 2012 Sep 29. PubMed PMID: 23054358; PubMed Central PMCID: PMC3492578.

13: Polit JT, Ciereszko I. Sucrose synthase activity and carbohydrates content in relation to phosphorylation status of Vicia faba root meristems during reactivation from sugar depletion. J Plant Physiol. 2012 Nov 1;169(16):1597-606. doi: 10.1016/j.jplph.2012.04.017. Epub 2012 Jul 4. PubMed PMID: 22770419.

14: Yu Y, Yan J, Zhang Q, Yan L, Li M, Zhou Q, Qiao J. Successful reprogramming of differentiated cells by somatic cell nuclear transfer, using in vitro-matured oocytes with a modified activation method. J Tissue Eng Regen Med. 2013 Nov;7(11):855-63. doi: 10.1002/term.1476. Epub 2012 May 15. PubMed PMID: 22589148.

15: Bevacqua RJ, Pereyra-Bonnet F, Olivera R, Hiriart MI, Sipowicz P, Fernandez-Martín R, Radrizzani M, Salamone DF. Production of IVF transgene-expressing bovine embryos using a novel strategy based on cell cycle inhibitors. Theriogenology. 2012 Jul 1;78(1):57-68. doi: 10.1016/j.theriogenology.2012.01.020. Epub 2012 Apr 10. PubMed PMID: 22494679.

16: Vichera G, Olivera R, Salamone D. Oocyte genome cloning used in biparental bovine embryo reconstruction. Zygote. 2013 Feb;21(1):21-9. doi: 10.1017/S0967199412000081. Epub 2012 Apr 5. PubMed PMID: 22475091.

17: Yin Y, Tang L, Zhang P, Kong D, Wang Z, Guan J, Song G, Tang B, Li Z. Optimizing the conditions for in vitro maturation and artificial activation of sika deer (Cervus nippon hortulorum) oocytes. Reprod Domest Anim. 2013 Feb;48(1):27-32. doi: 10.1111/j.1439-0531.2012.02020.x. Epub 2012 Mar 28. PubMed PMID: 22458270.

18: Takeda K, Srirattana K, Matsukawa K, Akagi S, Kaneda M, Tasai M, Nirasawa K, Pinkert CA, Parnpai R, Nagai T. Influence of intergeneric/interspecies mitochondrial injection; parthenogenetic development of bovine oocytes after injection of mitochondria derived from somatic cells. J Reprod Dev. 2012;58(3):323-9. Epub 2012 Mar 9. PubMed PMID: 22447326.

19: Sellars MJ, Arce SM, Hertzler PL. Triploidy induction in the Pacific white shrimp Litopenaeus vannamei: an assessment of induction agents and parameters, embryo viability, and early larval survival. Mar Biotechnol (NY). 2012 Dec;14(6):740-51. doi: 10.1007/s10126-012-9439-2. Epub 2012 Feb 11. PubMed PMID: 22327414.

20: Lima JS, Leão DL, Sampaio RV, Brito AB, Santos RR, Miranda MS, Ohashi OM, Domingues SF. Embryo production by parthenogenetic activation and fertilization of in vitro matured oocytes from Cebus apella. Zygote. 2013 May;21(2):162-6. doi: 10.1017/S0967199411000736. Epub 2012 Jan 10. PubMed PMID: 22230224.