Adamantanine | CAS# 42381-05-5 | transport inhibitor

Adamantanine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591073

CAS#: 42381-05-5

Description: Adamantanine is a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties.

Chemical Structure

Adamantanine

CAS# 42381-05-5

Instruction

Theoretical Analysis

MedKoo Cat#: 591073
Name: Adamantanine
CAS#: 42381-05-5
Chemical Formula: C11H17NO2
Exact Mass: 195.13
Molecular Weight: 195.260
Elemental Analysis: C, 67.66; H, 8.78; N, 7.17; O, 16.39

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 690
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NSC 145160; NSC145160; NSC-145160; Adamantanine; 2-Aminoadamantane-2-carboxylic acid

IUPAC/Chemical Name: 2-Aminoadamantane-2-carboxylic acid

InChi Key: WQMQRNCPZFUGID-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H17NO2/c12-11(10(13)14)8-2-6-1-7(4-8)5-9(11)3-6/h6-9H,1-5,12H2,(H,13,14)

SMILES Code: O=C(C1(N)C2CC3CC(C2)CC1C3)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 195.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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Reconstitution Calculator

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1: Nagaswa HT, Elberling JA, Shirota FN. 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16(7):823-6. doi: 10.1021/jm00265a016. PMID: 4725929.

2: Szcześniak P, Pieczykolan M, Stecko S. The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81(3):1057-74. doi: 10.1021/acs.joc.5b02628. Epub 2016 Jan 12. PMID: 26726732.

3: Mazzier D, Grassi L, Moretto A, Alemán C, Formaggio F, Toniolo C, Crisma M. En route towards the peptide γ-helix: X-ray diffraction analyses and conformational energy calculations of Adm-rich short peptides. J Pept Sci. 2017 Apr;23(4):346-362. doi: 10.1002/psc.2957. Epub 2016 Dec 22. PMID: 28004461.

4: Ingham RJ, Battilocchio C, Fitzpatrick DE, Sliwinski E, Hawkins JM, Ley SV. A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences. Angew Chem Int Ed Engl. 2015 Jan 2;54(1):144-8. doi: 10.1002/anie.201409356. Epub 2014 Nov 5. PMID: 25377747; PMCID: PMC4502965.

5: Battilocchio C, Guetzoyan L, Cervetto C, Di Cesare Mannelli L, Frattaroli D, Baxendale IR, Maura G, Rossi A, Sautebin L, Biava M, Ghelardini C, Marcoli M, Ley SV. Flow Synthesis and Biological Studies of an Analgesic Adamantane Derivative That Inhibits P2X7-Evoked Glutamate Release. ACS Med Chem Lett. 2013 May 22;4(8):704-9. doi: 10.1021/ml400079h. PMID: 24900736; PMCID: PMC4027228.

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