1-Acridinamine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591023

CAS#: 578-06-3

Description: 1-Acridinamine is a biochemical.


Chemical Structure

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1-Acridinamine
CAS# 578-06-3

Theoretical Analysis

MedKoo Cat#: 591023
Name: 1-Acridinamine
CAS#: 578-06-3
Chemical Formula: C13H10N2
Exact Mass: 194.08
Molecular Weight: 194.240
Elemental Analysis: C, 80.39; H, 5.19; N, 14.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 1-Aminoacridine; 1-Aminoakridin; 1-Acridinamine

IUPAC/Chemical Name: 1-Acridinamine

InChi Key: LOMMDWBTANPFEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10N2/c14-11-5-3-7-13-10(11)8-9-4-1-2-6-12(9)15-13/h1-8H,14H2

SMILES Code: NC1=CC=CC2=NC3=CC=CC=C3C=C21

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 194.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Huang Y, Liu G, Yang F, Xing X, Li Y, Huang Z, Yuan H. Induction of apoptosis and proliferation inhibition of hepatocellular carcinoma by 6-chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA): in vitro and vivo studies. Cancer Cell Int. 2017 Jul 3;17:66. doi: 10.1186/s12935-017-0435-5. eCollection 2017. PubMed PMID: 28680363; PubMed Central PMCID: PMC5496258.

2: Cerón-Carrasco JP, Ruiz J, Vicente C, de Haro C, Bautista D, Zúñiga J, Requena A. DFT Simulation of Structural and Optical Properties of 9-Aminoacridine Half-Sandwich Ru(II), Rh(III), and Ir(III) Antitumoral Complexes and Their Interaction with DNA. J Chem Theory Comput. 2017 Aug 8;13(8):3898-3910. doi: 10.1021/acs.jctc.7b00139. Epub 2017 Jul 6. PubMed PMID: 28641006.

3: Ishigami-Yuasa M, Watanabe Y, Mori T, Masuno H, Fujii S, Kikuchi E, Uchida S, Kagechika H. Development of WNK signaling inhibitors as a new class of antihypertensive drugs. Bioorg Med Chem. 2017 Jul 15;25(14):3845-3852. doi: 10.1016/j.bmc.2017.05.034. Epub 2017 May 19. PubMed PMID: 28566208.

4: Xiao S, Wang T, Ma X, Qin Y, Li X, Zhao Z, Liu X, Wang X, Xie H, Jiang Q, Sun L, Luo B, Shang L, Chen W, Bai Y, Tang M, He M, Wu L, Ma Q, Hou D, He J. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age Ageing. 2017 Sep 1;46(5):767-773. doi: 10.1093/ageing/afx045. PubMed PMID: 28419192.

5: Zhou D, Guo S, Zhang M, Liu Y, Chen T, Li Z. Mass spectrometry imaging of small molecules in biological tissues using graphene oxide as a matrix. Anal Chim Acta. 2017 Apr 15;962:52-59. doi: 10.1016/j.aca.2017.01.043. Epub 2017 Jan 31. PubMed PMID: 28231880.

6: Campbell AP, Wakelin LP, Denny WA, Finch AM. Homobivalent Conjugation Increases the Allosteric Effect of 9-aminoacridine at the α1-Adrenergic Receptors. Mol Pharmacol. 2017 Feb;91(2):135-144. doi: 10.1124/mol.116.105874. Epub 2016 Nov 30. PubMed PMID: 27903755.

7: Kava HW, Murray V. CpG methylation increases the DNA binding of 9-aminoacridine carboxamide Pt analogues. Bioorg Med Chem. 2016 Oct 1;24(19):4701-4710. doi: 10.1016/j.bmc.2016.08.011. Epub 2016 Aug 8. PubMed PMID: 27567075.

8: Knezević Nikola Z. Magnetic Field-Induced Accentuation of Drug Release from Core/Shell Magnetic Mesoporous Silica Nanoparticles for Anticancer Treatment. J Nanosci Nanotechnol. 2016 Apr;16(4):4195-9. PubMed PMID: 27451786.

9: Ly A, Buck A, Balluff B, Sun N, Gorzolka K, Feuchtinger A, Janssen KP, Kuppen PJ, van de Velde CJ, Weirich G, Erlmeier F, Langer R, Aubele M, Zitzelsberger H, McDonnell L, Aichler M, Walch A. High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue. Nat Protoc. 2016 Aug;11(8):1428-43. doi: 10.1038/nprot.2016.081. Epub 2016 Jul 14. PubMed PMID: 27414759.

10: Matsuda S, Matsuda Y, Yanagisawa SY, Ikura M, Ikura T, Matsuda T. Disruption of DNA Damage-Response by Propyl Gallate and 9-Aminoacridine. Toxicol Sci. 2016 Jun;151(2):224-35. doi: 10.1093/toxsci/kfw039. Epub 2016 Feb 28. PubMed PMID: 26928355.

11: Kang JY, Kwon O, Gil JY, Oh DB. Comparison of fluorescent tags for analysis of mannose-6-phosphate glycans. Anal Biochem. 2016 May 15;501:1-3. doi: 10.1016/j.ab.2016.02.004. Epub 2016 Feb 11. PubMed PMID: 26876105.

12: Bebawy LI, Elghobashy MR, Abbas SS, Shokry RF. Chromatographic Determination of Aminoacridine Hydrochloride, Lidocaine Hydrochloride and Lidocaine Toxic Impurity in Oral Gel. J Chromatogr Sci. 2016 Apr;54(4):492-9. doi: 10.1093/chromsci/bmv170. Epub 2015 Dec 15. PubMed PMID: 26671412; PubMed Central PMCID: PMC4885379.

13: Ferguson DM, Jacobson BA, Jay-Dixon J, Patel MR, Kratzke RA, Raza A. Targeting Topoisomerase II Activity in NSCLC with 9-Aminoacridine Derivatives. Anticancer Res. 2015 Oct;35(10):5211-7. PubMed PMID: 26408679.

14: Munawar R, Mushtaq N, Arif S, Ahmed A, Akhtar S, Ansari S, Meer S, Saify ZS, Arif M. Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents. Am J Alzheimers Dis Other Demen. 2016 May;31(3):263-9. doi: 10.1177/1533317515603115. Epub 2015 Sep 17. PubMed PMID: 26385945.

15: Uno Y, Omori T. Re-analysis results using medians of the data from the JaCVAM-organized international validation study of the in vivo rat alkaline comet assay. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:182-7. doi: 10.1016/j.mrgentox.2015.06.005. Epub 2015 Jun 15. PubMed PMID: 26212310.

16: Nakagawa Y, Toyoizumi T, Sui H, Ohta R, Kumagai F, Usumi K, Saito Y, Yamakage K. In vivo comet assay of acrylonitrile, 9-aminoacridine hydrochloride monohydrate and ethanol in rats. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:104-13. doi: 10.1016/j.mrgentox.2015.04.001. Epub 2015 Apr 8. PubMed PMID: 26212299.

17: Jung YK, Park HG. Colorimetric detection of clinical DNA samples using an intercalator-conjugated polydiacetylene sensor. Biosens Bioelectron. 2015 Oct 15;72:127-32. doi: 10.1016/j.bios.2015.04.093. Epub 2015 Apr 30. PubMed PMID: 25978440.

18: Morgado-Palacin L, Llanos S, Urbano-Cuadrado M, Blanco-Aparicio C, Megias D, Pastor J, Serrano M. Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway. Carcinogenesis. 2014 Dec;35(12):2822-30. doi: 10.1093/carcin/bgu220. Epub 2014 Oct 24. PubMed PMID: 25344835.

19: Garin D, Virgone-Carlotta A, Gözel B, Oukhatar F, Perret P, Marti-Battle D, Touret M, Millet P, Dubois-Dauphin M, Meyronet D, Streichenberger N, Laferla FM, Demeunynck M, Chierici S, Sallanon Moulin M, Ghezzi C. COB231 targets amyloid plaques in post-mortem human brain tissue and in an Alzheimer mouse model. J Neurochem. 2015 Mar;132(5):609-18. PubMed PMID: 25258048.

20: Park KE, Kim JD, Nagashima Y, Kako K, Daitoku H, Matsui M, Park GG, Fukamizu A. Detection of choline and phosphatidic acid (PA) catalyzed by phospholipase D (PLD) using MALDI-QIT-TOF/MS with 9-aminoacridine matrix. Biosci Biotechnol Biochem. 2014;78(6):981-8. doi: 10.1080/09168451.2014.910102. Epub 2014 May 15. PubMed PMID: 25036123.