WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596060

CAS#: 1400742-66-6

Description: α-PVT is a synthetic stimulant of the cathinone class. It is a analogue of α-PVP where the phenyl ring has been replaced by thiophene. This product is discontinued (DEA controlled substance).

Chemical Structure

CAS# 1400742-66-6

Theoretical Analysis

MedKoo Cat#: 596060
Name: alpha-PVT
CAS#: 1400742-66-6
Chemical Formula: C13H19NOS
Exact Mass: 237.1187
Molecular Weight: 237.36
Elemental Analysis: C, 65.78; H, 8.07; N, 5.90; O, 6.74; S, 13.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: alpha-PVT; alpha-Pyrrolidinovalerothiophenone; J3.283.187G; alpha PVT; alphaPVT;

IUPAC/Chemical Name: 2-(pyrrolidin-1-yl)-1-(thiophen-2-yl)pentan-1-one


InChi Code: InChI=1S/C13H19NOS/c1-2-6-11(14-8-3-4-9-14)13(15)12-7-5-10-16-12/h5,7,10-11H,2-4,6,8-9H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 237.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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5: Cheong JH, Choi MJ, Jang CG, Lee YS, Lee S, Kim HJ, Seo JW, Yoon SS. Behavioral evidence for the abuse potential of the novel synthetic cathinone alpha-pyrrolidinopentiothiophenone (PVT) in rodents. Psychopharmacology (Berl). 2017 Mar;234(5):857-867. doi: 10.1007/s00213-017-4526-8. Epub 2017 Jan 9. PubMed PMID: 28070621.

6: Byrska B, Stanaszek R, Zuba D. Alpha-PVP as an active component of herbal highs in Poland between 2013 and 2015. Drug Test Anal. 2017 Aug;9(8):1267-1274. doi: 10.1002/dta.2151. Epub 2017 Feb 10. PubMed PMID: 28035764.

7: Eshleman AJ, Wolfrum KM, Reed JF, Kim SO, Swanson T, Johnson RA, Janowsky A. Structure-Activity Relationships of Substituted Cathinones, with Transporter Binding, Uptake, and Release. J Pharmacol Exp Ther. 2017 Jan;360(1):33-47. Epub 2016 Oct 31. PubMed PMID: 27799294; PubMed Central PMCID: PMC5193076.

8: Wojcieszak J, Andrzejczak D, Woldan-Tambor A, Zawilska JB. Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones. Neurotox Res. 2016 Aug;30(2):239-50. doi: 10.1007/s12640-016-9640-6. Epub 2016 Jun 13. PubMed PMID: 27295059.

9: Odoardi S, Romolo FS, Strano-Rossi S. A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013-2015. Forensic Sci Int. 2016 Aug;265:116-20. doi: 10.1016/j.forsciint.2016.01.037. Epub 2016 Feb 1. PubMed PMID: 26874736.

10: Swortwood MJ, Carlier J, Ellefsen KN, Wohlfarth A, Diao X, Concheiro-Guisan M, Kronstrand R, Huestis MA. In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant. Bioanalysis. 2016;8(1):65-82. doi: 10.4155/bio.15.237. Epub 2015 Dec 9. PubMed PMID: 26648097; PubMed Central PMCID: PMC5493968.

11: Helander A, Beck O, Bäckberg M. Intoxications by the dissociative new psychoactive substances diphenidine and methoxphenidine. Clin Toxicol (Phila). 2015 Jun;53(5):446-53. doi: 10.3109/15563650.2015.1033630. Epub 2015 Apr 17. PubMed PMID: 25881797.

12: Takayama T, Suzuki M, Todoroki K, Inoue K, Min JZ, Kikura-Hanajiri R, Goda Y, Toyo'oka T. UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome. Biomed Chromatogr. 2014 Jun;28(6):831-8. doi: 10.1002/bmc.3155. PubMed PMID: 24861751.

13: Kikura-Hanajiri R, Kawamura NU, Goda Y. Changes in the prevalence of new psychoactive substances before and after the introduction of the generic scheduling of synthetic cannabinoids in Japan. Drug Test Anal. 2014 Jul-Aug;6(7-8):832-9. doi: 10.1002/dta.1584. Epub 2013 Dec 26. PubMed PMID: 24573957.