WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 596058

CAS#: 1227067-61-9

Description: AMG-579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).

Chemical Structure

CAS# 1227067-61-9

Theoretical Analysis

MedKoo Cat#: 596058
Name: AMG-579
CAS#: 1227067-61-9
Chemical Formula: C25H23N5O3
Exact Mass: 441.1801
Molecular Weight: 441.49
Elemental Analysis: C, 68.01; H, 5.25; N, 15.86; O, 10.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AMG-579; J3.339.633C; AMG 579; AMG579;

IUPAC/Chemical Name: 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethan-1-one


InChi Code: InChI=1S/C25H23N5O3/c1-16(31)30-14-10-17(11-15-30)22-25(27-13-12-26-22)33-19-8-6-18(7-9-19)23(32)24-28-20-4-2-3-5-21(20)29-24/h2-9,12-13,17H,10-11,14-15H2,1H3,(H,28,29)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 441.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Hruszkewycz DP, Miles KC, Thiel OR, Stahl SS. Co/NHPI-mediated aerobic oxygenation of benzylic C-H bonds in pharmaceutically relevant molecules. Chem Sci. 2017 Feb 1;8(2):1282-1287. doi: 10.1039/c6sc03831j. Epub 2016 Oct 7. PubMed PMID: 28451270; PubMed Central PMCID: PMC5359875.

2: Wu Q, Kennedy MT, Nagapudi K, Kiang YH. Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of AMG 579, a PDE10A inhibitor. Int J Pharm. 2017 Apr 15;521(1-2):1-7. doi: 10.1016/j.ijpharm.2017.01.059. Epub 2017 Feb 2. PubMed PMID: 28163226.

3: Wilson SF, Kerr SJ, Rose MJ, James CA. Validation of a method for the determination of AMG 579 in cerebrospinal fluid with a focus on sample collection procedures for clinical trials. J Pharm Biomed Anal. 2015 Apr 10;108:49-55. doi: 10.1016/j.jpba.2015.01.055. Epub 2015 Feb 7. PubMed PMID: 25706859.

4: Hu E, Chen N, Bourbeau MP, Harrington PE, Biswas K, Kunz RK, Andrews KL, Chmait S, Zhao X, Davis C, Ma J, Shi J, Lester-Zeiner D, Danao J, Able J, Cueva M, Talreja S, Kornecook T, Chen H, Porter A, Hungate R, Treanor J, Allen JR. Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)e thanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). J Med Chem. 2014 Aug 14;57(15):6632-41. doi: 10.1021/jm500713j. Epub 2014 Aug 4. PubMed PMID: 25062128.