Acridine, hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 591012

CAS#: 17784-47-3

Description: Acridines are a class of compounds that are being extensively researched as potential anti-cancer drugs, and are well-known for their high cytotoxic activity; however, their clinical application is restricted or even excluded as a result of side effects. The potential of acridines as a topoisomerase II inhibitor or poison was first discovered in 1984, and since then, a considerable number of acridine derivatives have been tested as topoisomerase inhibitors/poisons.

Chemical Structure

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Acridine, hydrochloride
CAS# 17784-47-3
Instruction

Theoretical Analysis

MedKoo Cat#: 591012
Name: Acridine, hydrochloride
CAS#: 17784-47-3
Chemical Formula: C13H10ClN
Exact Mass: 215.05
Molecular Weight: 215.680
Elemental Analysis: C, 72.40; H, 4.67; Cl, 16.44; N, 6.49

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 550 2 Weeks
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Synonym: Acridine, monohydrochloride; Acridinium chloride

IUPAC/Chemical Name: Acridine, hydrochloride

InChi Key: XUESTGHCVFYOLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H9N.ClH/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12;/h1-9H;1H

SMILES Code: [H]Cl.C12=NC3=CC=CC=C3C=C1C=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 215.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Salehzadeh S, Hajibabaei F, Moghadam NH, Sharifinia S, Khazalpour S, Golbedaghi R. Binding Studies of Isoxsuprine Hydrochloride to Calf Thymus DNA Using Multispectroscopic and Molecular Docking Techniques. J Fluoresc. 2018 Jan;28(1):195-206. doi: 10.1007/s10895-017-2182-3. Epub 2017 Oct 6. PubMed PMID: 28986738.

2: Yamane M, Moriya S, Kokuba H. Visualization of ceramide channels in lysosomes following endogenous palmitoyl-ceramide accumulation as an initial step in the induction of necrosis. Biochem Biophys Rep. 2017 Mar 13;11:174-181. doi: 10.1016/j.bbrep.2017.02.010. eCollection 2017 Sep. PubMed PMID: 28955782; PubMed Central PMCID: PMC5614681.

3: Li X, Wang H, Xu Y, Liu W, Gong Q, Wang W, Qiu X, Zhu J, Mao F, Zhang H, Li J. Novel Vilazodone-Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation. ACS Chem Neurosci. 2017 Dec 20;8(12):2708-2721. doi: 10.1021/acschemneuro.7b00259. Epub 2017 Sep 19. PubMed PMID: 28872831.

4: Lam HT, Leonaviciute G, Zupančič O, Bernkop-Schnürch A. Thiomers: Impact of in situ cross-linkers on mucoadhesive properties. Eur J Pharm Sci. 2017 Aug 30;106:41-48. doi: 10.1016/j.ejps.2017.05.051. Epub 2017 May 23. PubMed PMID: 28549680.

5: Cobos-Puc L, Aguayo-Morales H, Ventura-Sobrevilla J, Luque-Contreras D, Chin-Chan M. Further analysis of the inhibition by agmatine on the cardiac sympathetic outflow: Role of the α(2)-adrenoceptor subtypes. Eur J Pharmacol. 2017 Jun 15;805:75-83. doi: 10.1016/j.ejphar.2017.03.009. Epub 2017 Mar 14. PubMed PMID: 28315344.

6: Jones JK, Tave A, Pezzullo JC, Kardia S, Lippes J. Long-term risk of reproductive cancer among Vietnamese women using the quinacrine hydrochloride pellet system vs. intrauterine devices or tubal ligation for contraception. Eur J Contracept Reprod Health Care. 2017 Apr;22(2):123-130. doi: 10.1080/13625187.2017.1285880. Epub 2017 Feb 13. PubMed PMID: 28256916.

7: Sawicki E, Schellens JH, Beijnen JH, Nuijen B. Pharmaceutical development of an amorphous solid dispersion formulation of elacridar hydrochloride for proof-of-concept clinical studies. Drug Dev Ind Pharm. 2017 Apr;43(4):584-594. doi: 10.1080/03639045.2016.1274901. Epub 2017 Jan 8. PubMed PMID: 28010129.

8: Rotin LE, MacLean N, Aman A, Gronda M, Lin FH, Hurren R, Wang X, Wrana JL, Datti A, Al-Awar R, Minden MD, Schimmer AD. Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells. Haematologica. 2016 Nov;101(11):e449-e453. Epub 2016 Sep 1. PubMed PMID: 27587383; PubMed Central PMCID: PMC5394872.

9: Wheate NJ, Dickson KA, Kim RR, Nematollahi A, Macquart RB, Kayser V, Yu G, Church WB, Marsh DJ. Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs. J Pharm Sci. 2016 Dec;105(12):3615-3625. doi: 10.1016/j.xphs.2016.09.008. Epub 2016 Oct 21. PubMed PMID: 27776769.

10: Patel N, Jain S, Lin S. Transdermal iontophoretic delivery of tacrine hydrochloride: Correlation between in vitro permeation and in vivo performance in rats. Int J Pharm. 2016 Nov 20;513(1-2):393-403. doi: 10.1016/j.ijpharm.2016.09.038. Epub 2016 Sep 12. PubMed PMID: 27633278.

11: Wang Y, Park D, Galermo AG, Gao D, Liu H, Lebrilla CB. Changes in cellular glycosylation of leukemia cells upon treatment with acridone derivatives yield insight into drug action. Proteomics. 2016 Dec;16(23):2977-2988. doi: 10.1002/pmic.201600218. PubMed PMID: 27717196.

12: Jacobs J, Moris M, De Samber T, Vrijdag J, De Borggraeve W, Van Meervelt L. The orthorhombic pseudopolymorph of tacrine hydrochloride. Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Oct 1;72(Pt 5):771-774. Epub 2016 Sep 29. PubMed PMID: 27698319.

13: Tournier N, Goutal S, Auvity S, Traxl A, Mairinger S, Wanek T, Helal OB, Buvat I, Soussan M, Caillé F, Langer O. Strategies to Inhibit ABCB1- and ABCG2-Mediated Efflux Transport of Erlotinib at the Blood-Brain Barrier: A PET Study on Nonhuman Primates. J Nucl Med. 2017 Jan;58(1):117-122. doi: 10.2967/jnumed.116.178665. Epub 2016 Aug 4. PubMed PMID: 27493269.

14: Pang X, Fan TJ. Cytotoxic effect and possible mechanisms of Tetracaine on human corneal epithelial cells in vitro. Int J Ophthalmol. 2016 Apr 18;9(4):497-504. doi: 10.18240/ijo.2016.04.04. eCollection 2016. PubMed PMID: 27162719; PubMed Central PMCID: PMC4853342.

15: Patel N, Jain S, Madan P, Lin S. Application of design of experiments for formulation development and mechanistic evaluation of iontophoretic tacrine hydrochloride delivery. Drug Dev Ind Pharm. 2016 Nov;42(11):1894-902. doi: 10.1080/03639045.2016.1181646. Epub 2016 May 10. PubMed PMID: 27100474.

16: Hansda C, Chakraborty U, Hussain SA, Bhattacharjee D, Paul PK. Layer-by-layer films and colloidal dispersions of graphene oxide nanosheets for efficient control of the fluorescence and aggregation properties of the cationic dye acridine orange. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:79-87. doi: 10.1016/j.saa.2015.12.006. Epub 2015 Dec 15. PubMed PMID: 26722674.

17: Bebawy LI, Elghobashy MR, Abbas SS, Shokry RF. Chromatographic Determination of Aminoacridine Hydrochloride, Lidocaine Hydrochloride and Lidocaine Toxic Impurity in Oral Gel. J Chromatogr Sci. 2016 Apr;54(4):492-9. doi: 10.1093/chromsci/bmv170. Epub 2015 Dec 15. PubMed PMID: 26671412; PubMed Central PMCID: PMC4885379.

18: Uno Y, Omori T. Re-analysis results using medians of the data from the JaCVAM-organized international validation study of the in vivo rat alkaline comet assay. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:182-7. doi: 10.1016/j.mrgentox.2015.06.005. Epub 2015 Jun 15. PubMed PMID: 26212310.

19: Nakagawa Y, Toyoizumi T, Sui H, Ohta R, Kumagai F, Usumi K, Saito Y, Yamakage K. In vivo comet assay of acrylonitrile, 9-aminoacridine hydrochloride monohydrate and ethanol in rats. Mutat Res Genet Toxicol Environ Mutagen. 2015 Jul;786-788:104-13. doi: 10.1016/j.mrgentox.2015.04.001. Epub 2015 Apr 8. PubMed PMID: 26212299.

20: Yamane M. Palmitoyl-ceramide accumulation with necrotic cell death in A549 cells, followed by a steep increase in sphinganine content. Biochim Open. 2015 Jun 21;1:11-27. doi: 10.1016/j.biopen.2015.06.001. eCollection 2015. PubMed PMID: 29632826; PubMed Central PMCID: PMC5889477.