MS438
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562723

CAS#: 512840-45-8

Description: MS438 is a potent agonist of the TSH receptor (TSHR).


Chemical Structure

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MS438
CAS# 512840-45-8

Theoretical Analysis

MedKoo Cat#: 562723
Name: MS438
CAS#: 512840-45-8
Chemical Formula: C20H17F3N2O3
Exact Mass: 390.1191
Molecular Weight: 390.36
Elemental Analysis: C, 61.54; H, 4.39; F, 14.60; N, 7.18; O, 12.30

Price and Availability

Size Price Availability Quantity
5.0mg USD 340.0 2 Weeks
10.0mg USD 560.0 2 Weeks
25.0mg USD 1025.0 2 Weeks
50.0mg USD 1750.0 2 Weeks
100.0mg USD 2400.0 2 Weeks
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Synonym: MS438; MS-438; MS 438;

IUPAC/Chemical Name: Benzyl 6 methyl-2-oxo-4-[4-(trifluoromethyl) phenyl]-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

InChi Key: CRJLZKUONIFOEQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H17F3N2O3/c1-12-16(18(26)28-11-13-5-3-2-4-6-13)17(25-19(27)24-12)14-7-9-15(10-8-14)20(21,22)23/h2-10,17H,11H2,1H3,(H2,24,25,27)

SMILES Code: O=C(C1=C(C)NC(NC1C2=CC=C(C(F)(F)F)C=C2)=O)OCC3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 390.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Latif R, Ali MR, Ma R, David M, Morshed SA, Ohlmeyer M, Felsenfeld DP, Lau Z, Mezei M, Davies TF. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25(1):51-62. doi: 10.1089/thy.2014.0119. PubMed PMID: 25333622; PubMed Central PMCID: PMC4291085.

MS438

5.0mg / USD 340.0