WB 4291

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341582

CAS#: 70974-81-1

Description: WB 4291 is a biochemcial.


Chemical Structure

img
WB 4291
CAS# 70974-81-1

Theoretical Analysis

MedKoo Cat#: 341582
Name: WB 4291
CAS#: 70974-81-1
Chemical Formula: C15H17Cl2N
Exact Mass: 281.0738
Molecular Weight: 282.208
Elemental Analysis: C, 63.84; H, 6.07; Cl, 25.12; N, 4.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WB 4291; WB-4291; WB4291.

IUPAC/Chemical Name: 1-Naphthalenamine, N,N-bis(2-chloroethyl)-3-methyl-

InChi Key: XRVKEBMOZFBYHX-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H17Cl2N/c1-12-10-13-4-2-3-5-14(13)15(11-12)18(8-6-16)9-7-17/h2-5,10-11H,6-9H2,1H3

SMILES Code: CC1=CC(N(CCCl)CCCl)=C2C=CC=CC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 282.208 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Qiao Z, Xiang P, Shen B, Shen M, Yan H. Simultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography-Tandem Mass Spectrometry and its Application in Three Poisoning Cases. J Forensic Sci. 2018 May;63(3):784-792. doi: 10.1111/1556-4029.13613. PubMed PMID: 29723420.

2: Kotthoff M, Rüdel H, Jürling H, Severin K, Hennecke S, Friesen A, Koschorreck J. First evidence of anticoagulant rodenticides in fish and suspended particulate matter: spatial and temporal distribution in German freshwater aquatic systems. Environ Sci Pollut Res Int. 2018 Mar 1. doi: 10.1007/s11356-018-1385-8. [Epub ahead of print] PubMed PMID: 29497938.

3: Sainsbury KA, Shore RF, Schofield H, Croose E, Pereira MG, Sleep D, Kitchener AC, Hantke G, McDonald RA. Long-term increase in secondary exposure to anticoagulant rodenticides in European polecats Mustela putorius in Great Britain. Environ Pollut. 2018 May;236:689-698. doi: 10.1016/j.envpol.2018.02.004. PubMed PMID: 29438955.

4: Seljetun KO, Eliassen E, Karinen R, Moe L, Vindenes V. Quantitative method for analysis of six anticoagulant rodenticides in faeces, applied in a case with repeated samples from a dog. Acta Vet Scand. 2018 Jan 17;60(1):3. doi: 10.1186/s13028-018-0357-9. PubMed PMID: 29343296; PubMed Central PMCID: PMC5772691.

5: Boitet M, Hammed A, Chatron N, Debaux JV, Benoit E, Lattard V. Elevated difenacoum metabolism is involved in the difenacoum-resistant phenotype observed in Berkshire rats homozygous for the L120Q mutation in the vitamin K epoxide reductase complex subunit 1 (Vkorc1) gene. Pest Manag Sci. 2018 Jun;74(6):1328-1334. doi: 10.1002/ps.4797. Epub 2018 Feb 21. PubMed PMID: 29155484.

6: López-García M, Romero-González R, Frenich AG. Determination of rodenticides and related metabolites in rabbit liver and biological matrices by liquid chromatography coupled to Orbitrap high resolution mass spectrometry. J Pharm Biomed Anal. 2017 Apr 15;137:235-242. doi: 10.1016/j.jpba.2017.01.043. Epub 2017 Jan 28. PubMed PMID: 28160742.

7: Fourel I, Damin-Pernik M, Benoit E, Lattard V. Core-shell LC-MS/MS method for quantification of second generation anticoagulant rodenticides diastereoisomers in rat liver in relationship with exposure of wild rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 15;1041-1042:120-132. doi: 10.1016/j.jchromb.2016.12.028. Epub 2016 Dec 21. PubMed PMID: 28033586.

8: Damin-Pernik M, Espana B, Besse S, Fourel I, Caruel H, Popowycz F, Benoit E, Lattard V. Development of an Ecofriendly Anticoagulant Rodenticide Based on the Stereochemistry of Difenacoum. Drug Metab Dispos. 2016 Dec;44(12):1872-1880. Epub 2016 Sep 12. PubMed PMID: 27621204.

9: Gül N, Yiğit N, Saygılı F, Demirel E, Geniş C. Comparison of the effects of difenacoum and brodifacoum on the ultrastructure of rat liver cells. Arh Hig Rada Toksikol. 2016 Sep 1;67(3):204-209. doi: 10.1515/aiht-2016-67-2783. PubMed PMID: 27749259.

10: Muscarella M, Armentano A, Iammarino M, Palermo C, Amorena M. Anticoagulant rodenticide poisoning in animals of Apulia and Basilicata, Italy. Vet Ital. 2016 Jun 30;52(2):153-9. doi: 10.12834/VetIt.118.333.3. PubMed PMID: 27393877.

11: Ruiz-Suárez N, Melero Y, Giela A, Henríquez-Hernández LA, Sharp E, Boada LD, Taylor MJ, Camacho M, Lambin X, Luzardo OP, Hartley G. Rate of exposure of a sentinel species, invasive American mink (Neovison vison) in Scotland, to anticoagulant rodenticides. Sci Total Environ. 2016 Nov 1;569-570:1013-1021. doi: 10.1016/j.scitotenv.2016.06.109. Epub 2016 Jul 4. PubMed PMID: 27387798.

12: Feinstein DL, Akpa BS, Ayee MA, Boullerne AI, Braun D, Brodsky SV, Gidalevitz D, Hauck Z, Kalinin S, Kowal K, Kuzmenko I, Lis K, Marangoni N, Martynowycz MW, Rubinstein I, van Breemen R, Ware K, Weinberg G. The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures. Ann N Y Acad Sci. 2016 Jun;1374(1):111-22. doi: 10.1111/nyas.13085. Epub 2016 May 31. Review. PubMed PMID: 27244102; PubMed Central PMCID: PMC4940222.

13: Gómez-Canela C, Lacorte S. Comprehensive characterization of anticoagulant rodenticides in sludge by liquid chromatography-tandem mass spectrometry. Environ Sci Pollut Res Int. 2016 Aug;23(15):15739-48. doi: 10.1007/s11356-016-6743-9. Epub 2016 May 4. PubMed PMID: 27146526.

14: Marangoni MN, Martynowycz MW, Kuzmenko I, Braun D, Polak PE, Weinberg G, Rubinstein I, Gidalevitz D, Feinstein DL. Membrane Cholesterol Modulates Superwarfarin Toxicity. Biophys J. 2016 Apr 26;110(8):1777-1788. doi: 10.1016/j.bpj.2016.03.004. PubMed PMID: 27119638; PubMed Central PMCID: PMC4850322.

15: Leporati M, Salomone A, Golè G, Vincenti M. Determination of Anticoagulant Rodenticides and α-Chloralose in Human Hair. Application to a Real Case. J Anal Toxicol. 2016 May;40(4):277-85. doi: 10.1093/jat/bkw019. Epub 2016 Mar 16. PubMed PMID: 26984200.

16: Geduhn A, Jacob J, Schenke D, Keller B, Kleinschmidt S, Esther A. Relation between Intensity of Biocide Practice and Residues of Anticoagulant Rodenticides in Red Foxes (Vulpes vulpes). PLoS One. 2015 Sep 29;10(9):e0139191. doi: 10.1371/journal.pone.0139191. eCollection 2015. PubMed PMID: 26418154; PubMed Central PMCID: PMC4587841.

17: Maršálek P, Modrá H, Doubková V, Večerek V. Simultaneous determination of ten anticoagulant rodenticides in tissues by column-switching UHPLC-ESI-MS/MS. Anal Bioanal Chem. 2015 Oct;407(25):7849-54. doi: 10.1007/s00216-015-8954-1. Epub 2015 Aug 18. PubMed PMID: 26280206.

18: Bidny S, Gago K, David M, Duong T, Albertyn D, Gunja N. A validated LC-MS-MS method for simultaneous identification and quantitation of rodenticides in blood. J Anal Toxicol. 2015 Apr;39(3):219-24. doi: 10.1093/jat/bku175. Epub 2015 Jan 16. PubMed PMID: 25595137.

19: López-Perea JJ, Camarero PR, Molina-López RA, Parpal L, Obón E, Solá J, Mateo R. Interspecific and geographical differences in anticoagulant rodenticide residues of predatory wildlife from the Mediterranean region of Spain. Sci Total Environ. 2015 Apr 1;511:259-67. doi: 10.1016/j.scitotenv.2014.12.042. Epub 2014 Dec 26. PubMed PMID: 25546464.

20: Card DJ, Francis S, Deuchande K, Harrington DJ. Superwarfarin poisoning and its management. BMJ Case Rep. 2014 Oct 13;2014. pii: bcr2014206360. doi: 10.1136/bcr-2014-206360. PubMed PMID: 25312896; PubMed Central PMCID: PMC4195219.