myomiR-IN-1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562714

CAS#: 1392224-59-7

Description: myomiR-IN-1 is an inhibitor of myomiRs. It acts by inhibiting the translation of myoD in C2C12 cells without changing the expression level of myoD mRNA and downregulating expression of differentiation markers.


Chemical Structure

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myomiR-IN-1
CAS# 1392224-59-7

Theoretical Analysis

MedKoo Cat#: 562714
Name: myomiR-IN-1
CAS#: 1392224-59-7
Chemical Formula: C33H27NO6
Exact Mass: 533.1838
Molecular Weight: 533.58
Elemental Analysis: C, 74.28; H, 5.10; N, 2.63; O, 17.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: myomiR-IN-1; myomiR IN 1; myomiRIN1; myomiR inhibitor-1; myomiR inhibitor 1;

IUPAC/Chemical Name: 8-(tert-Butylcarboxy)oxy-5-(8a-methoxy-3,8-dioxo-2-phenyl-2a,3,8,8a-tetrahydro-cyclobuta[b]naphthalen-1-yl)-quinoline

InChi Key: GNUJEUMWYJVRKO-UHFFFAOYSA-N

InChi Code: InChI=1S/C33H27NO6/c1-32(2,3)40-31(37)39-24-17-16-20(21-15-10-18-34-28(21)24)26-25(19-11-6-5-7-12-19)27-29(35)22-13-8-9-14-23(22)30(36)33(26,27)38-4/h5-18,27H,1-4H3

SMILES Code: O=C(C1=C2C=CC=C1)C(C(C3=C4C=CC=NC4=C(OC(OC(C)(C)C)=O)C=C3)=C5C6=CC=CC=C6)(OC)C5C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 533.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Graham ZA, De Gasperi R, Bauman WA, Cardozo CP. Recombinant myostatin reduces highly expressed microRNAs in differentiating C2C12 cells. Biochem Biophys Rep. 2017 Mar;9:273-280. PubMed PMID: 28691106; PubMed Central PMCID: PMC5500170.

2: Tan SB, Li J, Chen X, Zhang W, Zhang D, Zhang C, Li D, Zhang Y. Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway. Chem Biol. 2014 Oct 23;21(10):1265-1270. doi: 10.1016/j.chembiol.2014.06.011. Epub 2014 Sep 18. PubMed PMID: 25242288.