8-OH-DPAT
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MedKoo CAT#: 555253

CAS#: 78950-78-4 (free base)

Description: 8-OH-DPAT is a 5HT-1a agonist.


Chemical Structure

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8-OH-DPAT
CAS# 78950-78-4 (free base)

Theoretical Analysis

MedKoo Cat#: 555253
Name: 8-OH-DPAT
CAS#: 78950-78-4 (free base)
Chemical Formula: C16H25NO
Exact Mass: 247.1936
Molecular Weight: 247.382
Elemental Analysis: C, 77.68; H, 10.19; N, 5.66; O, 6.47

Price and Availability

Size Price Availability Quantity
200.0mg USD 1050.0 2 Weeks
500.0mg USD 1650.0 2 Weeks
1.0g USD 2950.0 2 Weeks
2.0g USD 4750.0 2 Weeks
5.0g USD 6950.0 2 Weeks
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Related CAS #: 76135-31-4 (HBr)   78950-78-4 (free base)   141215-27-2 (HCl)    

Synonym: 8-OH-DPAT; 8-Hydroxy-DPAT; 8OH-DPAT;

IUPAC/Chemical Name: 8-Hydroxy-2-(di-n-propylamino)tetralin

InChi Key: ASXGJMSKWNBENU-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3

SMILES Code: CCCN(C1CC2=C(C=CC=C2O)CC1)CCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 247.382 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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11: Groft ML, Normann MC, Nicklas PR, Jagielo-Miller JE, McLaughlin PJ. Biphasic effects of 5-HT(1A) agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task. Naunyn Schmiedebergs Arch Pharmacol. 2019 Jul 9. doi: 10.1007/s00210-019-01684-5. [Epub ahead of print] PubMed PMID: 31289857.

12: Yang Y, Lin D, Bao C, Huang H, Ye H. Serotonergic Mechanisms of Oocyte Germinal Vesicle Breakdown in the Mud Crab, Scylla paramamosain. Front Physiol. 2019 Jun 19;10:797. doi: 10.3389/fphys.2019.00797. eCollection 2019. PubMed PMID: 31275175; PubMed Central PMCID: PMC6593242.

13: Odland AU, Jessen L, Fitzpatrick CM, Andreasen JT. 8-OH-DPAT Induces Compulsive-like Deficit in Spontaneous Alternation Behavior: Reversal by MDMA but Not Citalopram. ACS Chem Neurosci. 2019 Jul 17;10(7):3094-3100. doi: 10.1021/acschemneuro.8b00593. Epub 2019 Jun 17. PubMed PMID: 31244057.

14: Xiao WZ, Zhou WH, Ma Q, Cui WG, Mei QY, Zhao X. Serotonergically dependent antidepressant-like activity on behavior and stress axis responsivity of acacetin. Pharmacol Res. 2019 Aug;146:104310. doi: 10.1016/j.phrs.2019.104310. Epub 2019 Jun 20. PubMed PMID: 31229563.

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16: Zhou X, Li G, Zhang S, Wu J. 5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model. Front Cell Neurosci. 2019 May 3;13:167. doi: 10.3389/fncel.2019.00167. eCollection 2019. PubMed PMID: 31130845; PubMed Central PMCID: PMC6509153.

17: Nagata A, Nakayama K, Nakamura S, Mochizuki A, Gemba C, Aoki R, Dantsuji M, Maki K, Inoue T. Serotonin(1B) receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons. Brain Res Bull. 2019 Jul;149:260-267. doi: 10.1016/j.brainresbull.2019.05.001. Epub 2019 May 7. PubMed PMID: 31075304.

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19: Depoortère R, Bardin L, Varney MA, Newman-Tancredi A. Serotonin 5-HT(1A) Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model. ACS Chem Neurosci. 2019 Jul 17;10(7):3101-3107. doi: 10.1021/acschemneuro.8b00661. Epub 2019 Apr 2. PubMed PMID: 30929419.

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8-OH-DPAT

200.0mg / USD 1050.0