Aconiazide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571589

CAS#: 13410-86-1

Description: Aconiazide is an anti-tuberculosis prodrug.

Chemical Structure

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Aconiazide
CAS# 13410-86-1
Instruction

Theoretical Analysis

MedKoo Cat#: 571589
Name: Aconiazide
CAS#: 13410-86-1
Chemical Formula: C15H13N3O4
Exact Mass: 299.09
Molecular Weight: 299.290
Elemental Analysis: C, 60.20; H, 4.38; N, 14.04; O, 21.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Aconiazida

IUPAC/Chemical Name: Isonicotinic acid (o-(carboxymethoxy)benzylidene)hydrazide

InChi Key: MDFXJBQEWLCGHP-RQZCQDPDSA-N

InChi Code: InChI=1S/C15H13N3O4/c19-14(20)10-22-13-4-2-1-3-12(13)9-17-18-15(21)11-5-7-16-8-6-11/h1-9H,10H2,(H,18,21)(H,19,20)/b17-9+

SMILES Code: O=C(N/N=C/C1=CC=CC=C1OCC(O)=O)C2=CC=NC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 299.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: West RW, Kodell RL. A comparison of methods of benchmark-dose estimation for continuous response data. Risk Anal. 1999 Jun;19(3):453-9. PubMed PMID: 10765417.

2: Hothorn LA, Hauschke D. Identifying the maximum safe dose: a multiple testing approach. J Biopharm Stat. 2000 Feb;10(1):15-30. PubMed PMID: 10709798.

3: Bosch RJ, Wypij D, Ryan LM. A semiparametric approach to risk assessment for quantitative outcomes. Risk Anal. 1996 Oct;16(5):657-65. PubMed PMID: 8962516.

4: Hansen EB Jr, Dooley KL, Thompson HC Jr. High-performance liquid chromatographic analysis of the antituberculosis drugs aconiazide and isoniazid. J Chromatogr B Biomed Appl. 1995 Aug 18;670(2):259-66. PubMed PMID: 8548016.

5: Peloquin CA, James GT, Craig LD, Kim M, McCarthy EA, Iklé D, Iseman MD. Pharmacokinetic evaluation of aconiazide, a potentially less toxic isoniazid prodrug. Pharmacotherapy. 1994 Jul-Aug;14(4):415-23. PubMed PMID: 7937278.

6: Kodell RL, West RW. Upper confidence limits on excess risk for quantitative responses. Risk Anal. 1993 Apr;13(2):177-82. PubMed PMID: 8502790.

7: Held HR, Landi S. Binding of toxic metabolites of isoniazid by aconiazide. J Pharm Sci. 1980 Nov;69(11):1284-7. PubMed PMID: 7452457.