T-5601640
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MedKoo CAT#: 562706

CAS#: 924473-59-6

Description: T-5601640 is a selective LIM kinase 2 (LIMK2) inhibitor.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1550 2 Weeks
1g USD 2850 2 Weeks
2g USD 5150 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-02. Prices are subject to change without notice.

T-5601640, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562706
Name: T-5601640
CAS#: 924473-59-6
Chemical Formula: C19H14F3N3O3
Exact Mass: 389.0987
Molecular Weight: 389.33
Elemental Analysis: C, 58.62; H, 3.62; F, 14.64; N, 10.79; O, 12.33


Synonym: T-5601640; T 5601640; T5601640; T56LIMKi; T56 LIMKi; T56-LIMKi;

IUPAC/Chemical Name: 3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide

InChi Key: XVOKFRPKSAWELK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27)

SMILES Code: O=C(C1=CC(C)=NO1)NC2=CC=CC(C(NC3=CC=CC(C(F)(F)F)=C3)=O)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rak R, Haklai R, Elad-Tzfadia G, Wolfson HJ, Carmeli S, Kloog Y. Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model. Oncoscience. 2014 Jan 1;1(1):39-48. eCollection 2014. PubMed PMID: 25593987; PubMed Central PMCID: PMC4295757.

2: Rak R, Kloog Y. Targeting LIM kinase in cancer and neurofibromatosis. Cell Cycle. 2014;13(9):1360-1. doi: 10.4161/cc.28748. Epub 2014 Apr 3. PubMed PMID: 24698779; PubMed Central PMCID: PMC4050127.

3: Mashiach-Farkash E, Rak R, Elad-Sfadia G, Haklai R, Carmeli S, Kloog Y, Wolfson HJ. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39. PubMed PMID: 22776759; PubMed Central PMCID: PMC3442289.