N-Methylquipazine
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MedKoo CAT#: 596046

CAS#: 28614-26-8

Description: N-Methylquipazine is a 5-HT3 agonist. Has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites.


Chemical Structure

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N-Methylquipazine
CAS# 28614-26-8

Theoretical Analysis

MedKoo Cat#: 596046
Name: N-Methylquipazine
CAS#: 28614-26-8
Chemical Formula: C14H17N3
Exact Mass: 227.14
Molecular Weight: 227.142
Elemental Analysis: C, 73.98; H, 7.54; N, 18.49

Price and Availability

Size Price Availability Quantity
20mg USD 270
100mg USD 430
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Synonym: N-Methylquipazine;NMethylquipazine; N Methylquipazine; J366.838J;

IUPAC/Chemical Name: 2-(4-methylpiperazin-1-yl)quinoline

InChi Key: HOMWNUXPSJQSSU-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H17N3/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14/h2-7H,8-11H2,1H3

SMILES Code: CN1CCN(C2=NC3=CC=CC=C3C=C2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 227.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cappelli A, Giuliani G, Gallelli A, Valenti S, Anzini M, Mennuni L, Makovec F, Cupello A, Vomero S. Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor. Bioorg Med Chem. 2005 May 16;13(10):3455-60. PubMed PMID: 15848758.

2: Morreale A, Gálvez-Ruano E, Iriepa-Canalda I, Boyd DB. Arylpiperazines with serotonin-3 antagonist activity: a comparative molecular field analysis. J Med Chem. 1998 Jun 4;41(12):2029-39. PubMed PMID: 9622544.

3: Thorell JO, Stone-Elander S, Eriksson L, Ingvar M. N-methylquipazine: carbon-11 labelling of the 5-HT3 agonist and in vivo evaluation of its biodistribution using PET. Nucl Med Biol. 1997 Jul;24(5):405-12. PubMed PMID: 9290075.

4: Kurata K, Ashby CR Jr, Oberlender R, Tanii Y, Kurachi M, Rini NJ, Strecker RE. The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study. Synapse. 1996 Dec;24(4):313-21. PubMed PMID: 10638822.

5: Glennon RA, Ismaiel AE, McCarthy BG, Peroutka SJ. Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study. Eur J Pharmacol. 1989 Sep 22;168(3):387-92. PubMed PMID: 2583244.