WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562701
Description: YH-306 is a modulator of the FAK signalling pathway. It acts by suppressing colorectal tumour growth and metastasis.
MedKoo Cat#: 562701
Chemical Formula: C19H18N2O2
Exact Mass: 306.1368
Molecular Weight: 306.36
Elemental Analysis: C, 74.49; H, 5.92; N, 9.14; O, 10.44
This product is not in stock, which may be available by custom synthesis.
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Synonym: YH-306; YH 306; YH306;
IUPAC/Chemical Name: 2-(4-Hydroxyphenyl)-1-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-ethanone
InChi Key: WFTJZQLEQGPZBC-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H18N2O2/c22-14-7-5-13(6-8-14)11-19(23)21-10-9-16-15-3-1-2-4-17(15)20-18(16)12-21/h1-8,20,22H,9-12H2
SMILES Code: OC1=CC=C(CC(N(C2)CCC3=C2NC4=C3C=CC=C4)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 306.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Dai F, Chen Y, Huang L, Wang J, Zhang T, Li J, Tong W, Liu M, Yi Z. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95. doi: 10.1111/jcmm.12450. Epub 2014 Oct 29. PubMed PMID: 25351103; PubMed Central PMCID: PMC4407606.