MS437

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562700

CAS#: 541535-31-3

Description: MS437 is a potent agonist of the TSH receptor (TSHR).


Chemical Structure

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MS437
CAS# 541535-31-3

Theoretical Analysis

MedKoo Cat#: 562700
Name: MS437
CAS#: 541535-31-3
Chemical Formula: C22H24N2O
Exact Mass: 332.1889
Molecular Weight: 332.44
Elemental Analysis: C, 79.48; H, 7.28; N, 8.43; O, 4.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MS437; MS-437; MS 437;

IUPAC/Chemical Name: N,N-diisopropyl-2-phenylquinoline-4-carboxamide

InChi Key: LXECNSUVDZQPHW-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H24N2O/c1-15(2)24(16(3)4)22(25)19-14-21(17-10-6-5-7-11-17)23-20-13-9-8-12-18(19)20/h5-16H,1-4H3

SMILES Code: O=C(N(C(C)C)C(C)C)C1=C2C(C=CC=C2)=NC(C3=CC=CC=C3)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 332.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Latif R, Ali MR, Ma R, David M, Morshed SA, Ohlmeyer M, Felsenfeld DP, Lau Z, Mezei M, Davies TF. New small molecule agonists to the thyrotropin receptor. Thyroid. 2015 Jan;25(1):51-62. doi: 10.1089/thy.2014.0119. PubMed PMID: 25333622; PubMed Central PMCID: PMC4291085.