R 396

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571574

CAS#: 129809-09-2

Description: R 396 is a linear hexapeptide; NK-2 tachykinin receptor antagonist.


Chemical Structure

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R 396
CAS# 129809-09-2

Theoretical Analysis

MedKoo Cat#: 571574
Name: R 396
CAS#: 129809-09-2
Chemical Formula: C39H51N9O10
Exact Mass: 805.3759
Molecular Weight: 805.89
Elemental Analysis: C, 58.13; H, 6.38; N, 15.64; O, 19.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Acleu-asp-gln-trp-phe-glynh2; R 396

IUPAC/Chemical Name: Glycinamide, N-acetyl-L-leucyl-L-alpha-aspartyl-L-glutaminyl-L-tryptophyl-L-phenylalanyl-

InChi Key: LGPYZTNCSBONPI-ZJZGAYNASA-N

InChi Code: InChI=1S/C30H43N7O8/c1-5-32-27(42)23(13-18-15-33-20-9-7-6-8-19(18)20)36-28(43)21(10-11-25(31)39)35-30(45)24(14-26(40)41)37-29(44)22(12-16(2)3)34-17(4)38/h6-9,15-16,21-24,33H,5,10-14H2,1-4H3,(H2,31,39)(H,32,42)(H,34,38)(H,35,45)(H,36,43)(H,37,44)(H,40,41)/t21-,22-,23-,24-/m0/s1

SMILES Code: O=C(N)CNC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC(C)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 805.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pluck G. Preliminary Validation of a Free-to-Use, Brief Assessment of Adult Intelligence for Research Purposes: The Matrix Matching Test. Psychol Rep. 2018 Jan 1:33294118762589. doi: 10.1177/0033294118762589. [Epub ahead of print] PubMed PMID: 29540106.

2: Giannouli E, Bock O, Zijlstra W. Cognitive functioning is more closely related to real-life mobility than to laboratory-based mobility parameters. Eur J Ageing. 2017 Jun 20;15(1):57-65. doi: 10.1007/s10433-017-0434-3. eCollection 2018 Mar. PubMed PMID: 29531515; PubMed Central PMCID: PMC5840094.

3: Kardeş S, Karagülle M, Durak İ, Avcı A, Karagülle MZ. Association of oxidative stress with clinical characteristics in patients with rheumatoid arthritis. Eur J Clin Invest. 2018 Jan;48(1). doi: 10.1111/eci.12858. Epub 2017 Dec 8. PubMed PMID: 29144558.

4: Anyfanti P, Triantafyllou A, Gkaliagkousi E, Koletsos N, Athanasopoulos G, Zabulis X, Galanopoulou V, Aslanidis S, Douma S. Retinal vessel morphology in rheumatoid arthritis: Association with systemic inflammation, subclinical atherosclerosis, and cardiovascular risk. Microcirculation. 2017 Nov;24(8). doi: 10.1111/micc.12417. PubMed PMID: 28926162.

5: Koç M, Kaypakli O, Gözübüyük G, Yıldıray Şahin D. Coronary sinus lead delay index for optimization of coronary sinus lead placement. Ann Noninvasive Electrocardiol. 2018 Jan;23(1). doi: 10.1111/anec.12454. Epub 2017 May 30. PubMed PMID: 28557338.

6: Karakoyun S, Gökdeniz T, Gürsoy MO, Rencüzoğulları İ, Karabağ Y, Altıntaş B, Topçu S, Lazoğlu Z, Tanboğa İH, Sevimli S. Increased Glycated Hemoglobin Level is Associated With SYNTAX Score II in Patients With Type 2 Diabetes Mellitus. Angiology. 2016 Apr;67(4):384-90. doi: 10.1177/0003319715591752. Epub 2015 Jun 22. PubMed PMID: 26101367.

7: Kim JY, Bushnell CD, Park JH, Han SM, Im JH, Han SW, Baik JS, Park JH. Central aortic pressure and pulsatility index in acute ischemic stroke. J Neuroimaging. 2015 May-Jun;25(3):438-42. doi: 10.1111/jon.12151. Epub 2014 Jul 25. PubMed PMID: 25060557.

8: Müller J, Oberhoffer R, Barta C, Hulpke-Wette M, Hager A. Oscillometric carotid to femoral pulse wave velocity estimated with the Vicorder device. J Clin Hypertens (Greenwich). 2013 Mar;15(3):176-9. doi: 10.1111/jch.12045. Epub 2012 Dec 10. PubMed PMID: 23458589.

9: Mangine GT, Hoffman JR, Vazquez J, Pichardo N, Fragala MS, Stout JR. Predictors of fielding performance in professional baseball players. Int J Sports Physiol Perform. 2013 Sep;8(5):510-6. Epub 2013 Jan 23. PubMed PMID: 23348012.

10: Cantisani V, D'Andrea V, Biancari F, Medvedyeva O, Di Segni M, Olive M, Patrizi G, Redler A, De Antoni E E, Masciangelo R, Frezzotti F, Ricci P. Prospective evaluation of multiparametric ultrasound and quantitative elastosonography in the differential diagnosis of benign and malignant thyroid nodules: preliminary experience. Eur J Radiol. 2012 Oct;81(10):2678-83. doi: 10.1016/j.ejrad.2011.11.056. Epub 2012 Feb 20. PubMed PMID: 22357195.

11: Eroglu S, Sade LE, Polat E, Bozbas H, Ulus T, Muderrisoglu H. Association between serum gamma-glutamyltransferase activity and carotid intima-media thickness. Angiology. 2011 Feb;62(2):107-10. doi: 10.1177/0003319710386471. PubMed PMID: 21220370.

12: Muscatello MR, Bruno A, Scimeca G, Pandolfo G, Paduano R, Mico' U, Bellinghieri PM, Di Nardo F, Iannuzzo G, Cofini V, Di Orio F, Zoccali R. The relationship between anger and heterosexual behavior. An investigation in a nonclinical sample of urban Italian undergraduates. J Sex Med. 2010 Dec;7(12):3899-908. doi: 10.1111/j.1743-6109.2009.01640.x. PubMed PMID: 20059665.

13: Alicioglu B, Sarac A, Tokuc B. Does abdominal obesity cause increase in the amount of epidural fat? Eur Spine J. 2008 Oct;17(10):1324-8. doi: 10.1007/s00586-008-0724-8. Epub 2008 Jul 29. PubMed PMID: 18663486; PubMed Central PMCID: PMC2556475.

14: Thomas RC, Hawkins K, Kirkpatrick SH, Mondry TE, Gabram-Mendola S, Johnstone PA. Reduction of lymphedema using complete decongestive therapy: roles of prior radiation therapy and extent of axillary dissection. J Soc Integr Oncol. 2007 Summer;5(3):87-91. PubMed PMID: 17761127.

15: Schachner T, Feuchtner G, Bonaros N, Oehlinger A, Gassner E, Friedrich G, Smekal A, Laufer G, Bonatti J. Does preoperative multislice computed tomography predict operative times in total endoscopic coronary artery bypass grafting? Heart Surg Forum. 2005;8(5):E314-8. PubMed PMID: 16099732.

16: Mendonca RN, Alves JG, Filho JE. [Hospital costs due to violence against children and adolescents in Pernambuco State, Brazil, during 1999]. Cad Saude Publica. 2002 Nov-Dec;18(6):1577-81. Portuguese. PubMed PMID: 12488884.

17: Renzetti AR, Catalioto RM, Criscuoli M, Cucchi P, Lippi A, Guelfi M, Quartara L, Maggi CA. Characterization of [3H]MEN 11420, a novel glycosylated peptide antagonist radioligand of the tachykinin NK2 receptor. Biochem Biophys Res Commun. 1998 Jul 9;248(1):78-82. PubMed PMID: 9675089.

18: Nsa Allogho S, Nguyen-Le XK, Gobeil F, Pheng LH, Regoli D. Neurokinin receptors (NK1, NK2) in the mouse: a pharmacological study. Can J Physiol Pharmacol. 1997 Jun;75(6):552-7. PubMed PMID: 9276127.

19: Quartara L, Rovero P, Maggi CA. Peptide-based tachykinin NK2 receptor antagonists. Med Res Rev. 1995 Mar;15(2):139-55. Review. PubMed PMID: 7537837.

20: Wiesenfeld-Hallin Z, Luo L, Xu XJ, Maggi CA. Differential effects of selective tachykinin NK2 receptor antagonists in rat spinal cord. Eur J Pharmacol. 1994 Jan 4;251(1):99-102. PubMed PMID: 8137876.