MT-7716 free base

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MedKoo CAT#: 341572

CAS#: 610323-32-5 (free base)

Description: MT-7716 is a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala. MT-7716 dose-dependently (100-1000 nM) diminished evoked GABAA receptor-mediated inhibitory postsynaptic potentials (IPSPs) and increased paired-pulse facilitation (PPF) ratio of these evoked IPSPs, suggesting a presynaptic site of action of the MT-7716 by decreasing GABA release at CeA synapses. MT-7716 prevented the ethanol-induced augmentation of evoked IPSPs. MT-7716 significantly attenuated somatic alcohol withdrawal symptoms. MT-7716 is a promising candidate for alcoholism treatment remaining effective with chronic administration.

Chemical Structure

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MT-7716 free base
CAS# 610323-32-5 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 341572
Name: MT-7716 free base
CAS#: 610323-32-5 (free base)
Chemical Formula: C27H28N4O2
Exact Mass: 440.22
Molecular Weight: 440.547
Elemental Analysis: C, 73.61; H, 6.41; N, 12.72; O, 7.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 610323-32-5 (free base)   1215859-93-0 (HCl)   1215859-92-9 (HCl hydrate)    

Synonym: MT-7716 free base; W-212393; W 212393; W212393;

IUPAC/Chemical Name: (R)-2-(3-(1-(1,2-Dihydroacenaphthylen-1-yl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl)-N-methylacetamide

InChi Key: PJANMOWVUZBDQF-XMMPIXPASA-N

InChi Code: InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1

SMILES Code: O=C(NC)CN(C1=CC=CC=C1N2C3CCN([C@@H]4CC5=C6C4=CC=CC6=CC=C5)CC3)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. de Guglielmo G, Martin-Fardon R, Teshima K, Ciccocioppo R, Weiss F. MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats. Addict Biol. 2015 Jul;20(4):643-51. doi: 10.1111/adb.12157. Epub 2014 Jun 16. PMID: 24930632; PMCID: PMC4268094.

2. Kallupi M, Oleata CS, Luu G, Teshima K, Ciccocioppo R, Roberto M. MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala. Front Integr Neurosci. 2014 Feb 18;8:18. doi: 10.3389/fnint.2014.00018. PMID: 24600360; PMCID: PMC3927450.

3. Ciccocioppo R, Stopponi S, Economidou D, Kuriyama M, Kinoshita H, Heilig M, Roberto M, Weiss F, Teshima K. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology. 2014 Oct;39(11):2601-10. doi: 10.1038/npp.2014.113. Epub 2014 Jun 27. PMID: 24863033; PMCID: PMC4207340.