Isoxicam

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341568

CAS#: 34552-84-6

Description: Isoxicam is a biochemical.


Chemical Structure

img
Isoxicam
CAS# 34552-84-6

Theoretical Analysis

MedKoo Cat#: 341568
Name: Isoxicam
CAS#: 34552-84-6
Chemical Formula: C14H13N3O5S
Exact Mass: 335.0576
Molecular Weight: 335.334
Elemental Analysis: C, 50.15; H, 3.91; N, 12.53; O, 23.86; S, 9.56

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Isoxicam; W 8495; W-8495; W8495; BRN 0577221.

IUPAC/Chemical Name: 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-, 1,1-dioxide

InChi Key: YYUAYBYLJSNDCX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13N3O5S/c1-8-7-11(16-22-8)15-14(19)12-13(18)9-5-3-4-6-10(9)23(20,21)17(12)2/h3-7,18H,1-2H3,(H,15,16,19)

SMILES Code: O=C(C1=C(O)C2=CC=CC=C2S(N1C)(=O)=O)NC3=NOC(C)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 335.334 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Fornells E, Fuguet E, Mañé M, Ruiz R, Box K, Bosch E, Ràfols C. Effect of vinylpyrrolidone polymers on the solubility and supersaturation of drugs; a study using the Cheqsol method. Eur J Pharm Sci. 2018 May 30;117:227-235. doi: 10.1016/j.ejps.2018.02.025. Epub 2018 Feb 23. PubMed PMID: 29481859.

2: Klimenko K. R-based Tool for a Pairwise Structure-activity Relationship Analysis. Mol Inform. 2018 Apr;37(4):e1700094. doi: 10.1002/minf.201700094. Epub 2017 Oct 25. PubMed PMID: 29068147.

3: Goswami S, Majumdar A, Sarkar M. Painkiller Isoxicam and Its Copper Complex Can Form Inclusion Complexes with Different Cyclodextrins: A Fluorescence, Fourier Transform Infrared Spectroscopy, and Nuclear Magnetic Resonance Study. J Phys Chem B. 2017 Sep 14;121(36):8454-8466. doi: 10.1021/acs.jpcb.7b05649. Epub 2017 Aug 29. PubMed PMID: 28806512.

4: Goswami S, Ray S, Sarkar M. Spectroscopic studies on the interaction of DNA with the copper complexes of NSAIDs lornoxicam and isoxicam. Int J Biol Macromol. 2016 Dec;93(Pt A):47-56. doi: 10.1016/j.ijbiomac.2016.08.025. Epub 2016 Aug 20. PubMed PMID: 27554932.

5: Majumdar A, Kundu D, Sarkar M. Differential Effect of Oxicam Non-Steroidal Anti-Inflammatory Drugs on Membranes and Their Consequence on Membrane Fusion. J Phys Chem B. 2015 Jul 30;119(30):9627-39. doi: 10.1021/acs.jpcb.5b03918. Epub 2015 Jul 21. PubMed PMID: 26147344.

6: Xu S, Rouzer CA, Marnett LJ. Oxicams, a class of nonsteroidal anti-inflammatory drugs and beyond. IUBMB Life. 2014 Dec;66(12):803-11. doi: 10.1002/iub.1334. Epub 2014 Dec 23. Review. PubMed PMID: 25537198; PubMed Central PMCID: PMC5300000.

7: Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ. Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network. J Biol Chem. 2014 Mar 7;289(10):6799-808. doi: 10.1074/jbc.M113.517987. Epub 2014 Jan 14. PubMed PMID: 24425867; PubMed Central PMCID: PMC3945341.

8: Martínez-Araya JI, Salgado-Morán G, Glossman-Mitnik D. Computational nanochemistry report on the oxicams--conceptual DFT indices and chemical reactivity. J Phys Chem B. 2013 May 30;117(21):6339-51. doi: 10.1021/jp400241q. Epub 2013 May 20. PubMed PMID: 23656309.

9: Shirako J, Kawasaki M, Komine K, Kunisue Y, Terada M, Sasaki C, Irie W, Murakami C, Tonooka K, Tomobe K, Shinozuka T. Simultaneous determination for oxicam non-steroidal anti-inflammatory drugs in human serum by liquid chromatography-tandem mass spectrometry. Forensic Sci Int. 2013 Apr 10;227(1-3):100-2. doi: 10.1016/j.forsciint.2012.11.016. Epub 2012 Dec 27. PubMed PMID: 23273940.

10: Starek M, Krzek J. Quantification of Isoxicam in the Presence of Related Compounds by TLC-Densitometry. Acta Chim Slov. 2012 Jun;59(2):315-21. PubMed PMID: 24061247.

11: Buckley CE, Marguerie A, Roach AG, Goldsmith P, Fleming A, Alderton WK, Franklin RJ. Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects. Neuropharmacology. 2010 Sep;59(3):149-59. doi: 10.1016/j.neuropharm.2010.04.014. Epub 2010 May 5. PubMed PMID: 20450924.

12: Tamasi G, Casolaro M, Magnani A, Sega A, Chiasserini L, Messori L, Gabbiani C, Valiahdi SM, Jakupec MA, Keppler BK, Hursthouse MB, Cini R. New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro. J Inorg Biochem. 2010 Aug;104(8):799-814. doi: 10.1016/j.jinorgbio.2010.03.010. Epub 2010 Mar 27. PubMed PMID: 20447694.

13: Rodríguez-Barrientos D, Rojas-Hernández A, Gutiérrez A, Moya-Hernández R, Gómez-Balderas R, Ramírez-Silva MT. Determination of pKa values of tenoxicam from 1H NMR chemical shifts and of oxicams from electrophoretic mobilities (CZE) with the aid of programs SQUAD and HYPNMR. Talanta. 2009 Dec 15;80(2):754-62. doi: 10.1016/j.talanta.2009.07.058. Epub 2009 Aug 5. PubMed PMID: 19836548.

14: Lee HW, Ji HY, Kim HY, Lee KC, Lee HS. Liquid chromatography-tandem mass spectrometry method for the determination of meloxicam and its metabolite 5-carboxymeloxicam in human plasma. Bioanalysis. 2009 Apr;1(1):63-70. doi: 10.4155/bio.09.10. PubMed PMID: 21083189.

15: Rezaei B, Mallakpour S, Majidi N. Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum. Talanta. 2009 Apr 30;78(2):418-23. doi: 10.1016/j.talanta.2008.11.042. Epub 2008 Dec 3. PubMed PMID: 19203603.

16: Tamasi G, Serinelli F, Consumi M, Magnani A, Casolaro M, Cini R. Release studies from smart hydrogels as carriers for piroxicam and copper(II)-oxicam complexes as anti-inflammatory and anti-cancer drugs. X-ray structures of new copper(II)-piroxicam and -isoxicam complex molecules. J Inorg Biochem. 2008 Oct;102(10):1862-73. doi: 10.1016/j.jinorgbio.2008.06.009. Epub 2008 Jun 20. PubMed PMID: 18667239.

17: Hinz B, Brune K. Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology. Trends Pharmacol Sci. 2008 Aug;29(8):391-7. doi: 10.1016/j.tips.2008.06.004. Epub 2008 Jul 6. PubMed PMID: 18606461.

18: Kim YH, Ji HY, Park ES, Chae SW, Lee HS. Liquid chromatography-electrospray ionization tandem mass spectrometric determination of lornoxicam in human plasma. Arch Pharm Res. 2007 Jul;30(7):905-10. PubMed PMID: 17703745.

19: Cini R, Tamasi G, Defazio S, Hursthouse MB. Unusual coordinating behavior by three non-steroidal anti-inflammatory drugs from the oxicam family towards copper(II). Synthesis, X-ray structure for copper(II)-isoxicam, -meloxicam and -cinnoxicam-derivative complexes, and cytotoxic activity for a copper(II)-piroxicam complex. J Inorg Biochem. 2007 Aug;101(8):1140-52. Epub 2007 May 10. PubMed PMID: 17592742.

20: Ji HY, Lee HW, Kim YH, Jeong DW, Lee HS. Simultaneous determination of piroxicam, meloxicam and tenoxicam in human plasma by liquid chromatography with tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 5;826(1-2):214-9. Epub 2005 Oct 5. PubMed PMID: 16169293.