Saccharin sodium

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MedKoo CAT#: 581226

CAS#: 128-44-9

Description: Saccharin sodium is a type of artificial or nonnutritive sweetener. It is 200 to 700 times sweeter than sucrose but has a bitter aftertaste. Saccharin and its salts do not occur naturally. Saccharin sodium is used in the production of various foods and pharmaceutical products including soft drinks, candy, biscuits, jams, chewing gum, tinned fruit, medicine and toothpaste.

Chemical Structure

Saccharin sodium
CAS# 128-44-9

Theoretical Analysis

MedKoo Cat#: 581226
Name: Saccharin sodium
CAS#: 128-44-9
Chemical Formula: C7H4NNaO3S
Exact Mass: 204.981
Molecular Weight: 205.16
Elemental Analysis: C, 40.98; H, 1.97; N, 6.83; Na, 11.21; O, 23.39; S, 15.63

Price and Availability

Size Price Availability Quantity
100.0g USD 240.0 2 Weeks
500.0g USD 430.0 2 Weeks
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Related CAS #: 128-44-9(sodium)   82385-42-0 (sodium salt hydrate)  

Synonym: Saccharin sodium; CCRIS 706; Saccharin, sodium

IUPAC/Chemical Name: 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, Saccharin, sodium salt; Saccharinnatrium; Soluble gluside; Sweeta; Willosetten;


InChi Code: InChI=1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1

SMILES Code: O=C(C1=C2C=CC=C1)[N-]S2(=O)=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 205.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhao S, Yang X, Zhao H, Dong A, Wang J, Zhang M, Huang W. Water-compatible surface imprinting of 'Saccharin sodium' on silica surface for selective recognition and detection in aqueous solution. Talanta. 2015 Nov 1;144:717-25. doi: 10.1016/j.talanta.2015.05.086. Epub 2015 Jul 3. PubMed PMID: 26452882.

2: Ha MS, Ha SD, Choi SH, Bae DH. Assessment of Korean consumer exposure to sodium saccharin, aspartame and stevioside. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(7):1238-47. doi: 10.1080/19440049.2013.797114. Epub 2013 Jun 27. PubMed PMID: 23802660.

3: Zhang G, Wang L, Zhou X, Li Y, Gong D. Binding characteristics of sodium saccharin with calf thymus DNA in vitro. J Agric Food Chem. 2014 Jan 29;62(4):991-1000. doi: 10.1021/jf405085g. Epub 2014 Jan 17. PubMed PMID: 24437661.

4: Jamal MA, Rashad M, Khosa MK, Bhatti HN. Volumetric and acoustical behaviour of sodium saccharin in aqueous system over temperature range (20.0-45.0)°C. Food Chem. 2015 Apr 15;173:551-6. doi: 10.1016/j.foodchem.2014.10.047. Epub 2014 Oct 17. PubMed PMID: 25466058.

5: Sugiura J, Nakajima M. [Development of a New Method for Determination of Sodium Saccharin and Acesulfame Potassium with the Aid of Coagulant]. Shokuhin Eiseigaku Zasshi. 2015;56(5):200-4. doi: 10.3358/shokueishi.56.200. Japanese. PubMed PMID: 26537649.

6: El-Sabbagh OI. Synthesis of some new benzisothiazolone and benzenesulfonamide derivatives of biological interest starting from saccharin sodium. Arch Pharm (Weinheim). 2013 Oct;346(10):733-42. doi: 10.1002/ardp.201300110. Epub 2013 Sep 11. PubMed PMID: 24038507.

7: Zhao F, Gao G, Na H, Ma D, Wang X. [Simultaneous determination of saccharin sodium and synthetic colours in flavourings by solid phase extraction and high performance liquid chromatography]. Se Pu. 2013 May;31(5):490-3. Chinese. PubMed PMID: 24010353.

8: Knowles MA, Jani H, Hicks RM. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7(5):767-74. PubMed PMID: 2421938.

9: Masui T, Garland EM, Wang CY, Cohen SM. Effects of different types of diet and sodium saccharin on proliferation at the limiting ridge of the rat forestomach. Food Chem Toxicol. 1990 Jul;28(7):497-505. PubMed PMID: 2210522.

10: Icsel C, Yilmaz VT. In vitro DNA binding studies of the sweetening agent saccharin and its copper(II) and zinc(II) complexes. J Photochem Photobiol B. 2014 Jan 5;130:115-21. doi: 10.1016/j.jphotobiol.2013.11.001. Epub 2013 Nov 11. PubMed PMID: 24316657.

11: Hasegawa R, Greenfield RE, Murasaki G, Suzuki T, Cohen SM. Initiation of urinary bladder carcinogenesis in rats by freeze ulceration with sodium saccharin promotion. Cancer Res. 1985 Apr;45(4):1469-73. PubMed PMID: 3978613.

12: Csakai A, Smith C, Davis E, Martinko A, Coulup S, Yin H. Saccharin derivatives as inhibitors of interferon-mediated inflammation. J Med Chem. 2014 Jun 26;57(12):5348-55. doi: 10.1021/jm500409k. Epub 2014 Jun 4. PubMed PMID: 24897296; PubMed Central PMCID: PMC4079330.

13: Feijó FM, Ballard CR, Foletto KC, Batista BAM, Neves AM, Ribeiro MFM, Bertoluci MC. Saccharin and aspartame, compared with sucrose, induce greater weight gain in adult Wistar rats, at similar total caloric intake levels. Appetite. 2013 Jan;60(1):203-207. doi: 10.1016/j.appet.2012.10.009. Epub 2012 Oct 23. PubMed PMID: 23088901.

14: Valenti LP. Liquid chromatographic determination of quinine, hydroquinine, saccharin, and sodium benzoate in quinine beverages. J Assoc Off Anal Chem. 1985 Jul-Aug;68(4):782-4. PubMed PMID: 4030654.

15: Turner SD, Tinwell H, Piegorsch W, Schmezer P, Ashby J. The male rat carcinogens limonene and sodium saccharin are not mutagenic to male Big Blue rats. Mutagenesis. 2001 Jul;16(4):329-32. PubMed PMID: 11420401.

16: Demers DM, Fukushima S, Cohen SM. Effect of sodium saccharin and L-tryptophan on rat urine during bladder carcinogenesis. Cancer Res. 1981 Jan;41(1):108-12. PubMed PMID: 7448750.

17: Brizuela A, Romano E, Yurquina A, Locatelli S, Brandán SA. Experimental and theoretical vibrational investigation on the saccharinate ion in aqueous solution. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Sep;95:399-406. doi: 10.1016/j.saa.2012.04.003. Epub 2012 Apr 21. PubMed PMID: 22571944.

18: Yu A, Hashimura T, Nishio Y, Kanamaru H, Fukuzawa S, Yoshida O. Anti-promoting effect of nordihydroguaiaretic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine and sodium saccharin-induced rat urinary bladder carcinogenesis. Jpn J Cancer Res. 1992 Sep;83(9):944-8. PubMed PMID: 1429204; PubMed Central PMCID: PMC5918979.

19: Parker KR, von Borstel RC. Antimutagenesis in yeast by sodium chloride, potassium chloride, and sodium saccharin. Basic Life Sci. 1990;52:367-71. PubMed PMID: 2183776.

20: Mortazavi ZF, Islami MR, Khaleghi M. Highly Stereoselective Synthesis of Saccharin-Substituted β-Lactams via in Situ Generation of a Heterosubstituted Ketene and a Zwitterionic Intermediate as Potential Antibacterial Agents. Org Lett. 2015 Jun 19;17(12):3034-7. doi: 10.1021/acs.orglett.5b01309. Epub 2015 Jun 1. PubMed PMID: 26029959.