NSC745885

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562661

CAS#: 4219-52-7

Description: NSC745885 is a down-regulator of EZH2. It acts by inducing G2/M cell-cycle arrest of cancer cells and degradating p53 via proteasome-dependent and -independent pathways.

Chemical Structure

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NSC745885
CAS# 4219-52-7
Instruction

Theoretical Analysis

MedKoo Cat#: 562661
Name: NSC745885
CAS#: 4219-52-7
Chemical Formula: C14H6N2O2S
Exact Mass: 266.01
Molecular Weight: 266.274
Elemental Analysis: C, 63.15; H, 2.27; N, 10.52; O, 12.02; S, 12.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NSC745885; NSC-745885; NSC 745885;

IUPAC/Chemical Name: Anthra[1,2-c][1,2,5]thiadiazole-6,11-dione

InChi Key: SJPXIVLTCBBWKT-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H6N2O2S/c17-13-7-3-1-2-4-8(7)14(18)11-9(13)5-6-10-12(11)16-19-15-10/h1-6H

SMILES Code: O=C(C1=C2C=CC=C1)C3=C(C4=NSN=C4C=C3)C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 266.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dong G, Fang Y, Liu Y, Liu N, Wu S, Zhang W, Sheng C. Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors. Bioorg Med Chem Lett. 2017 May 1;27(9):1929-1933. doi: 10.1016/j.bmcl.2017.03.039. Epub 2017 Mar 18. PubMed PMID: 28351590.

2: Ali AA, Lee YR, Chen TC, Chen CL, Lee CC, Shiau CY, Chiang CH, Huang HS. Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. PLoS One. 2016 Apr 21;11(4):e0154278. doi: 10.1371/journal.pone.0154278. eCollection 2016. PubMed PMID: 27100886; PubMed Central PMCID: PMC4839570.

3: Tang SH, Huang HS, Wu HU, Tsai YT, Chuang MJ, Yu CP, Huang SM, Sun GH, Chang SY, Hsiao PW, Yu DS, Cha TL. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo. Oncotarget. 2014 Nov 15;5(21):10342-55. PubMed PMID: 25431950; PubMed Central PMCID: PMC4279377.

4: Chen YW, Huang HS, Shieh YS, Ma KH, Huang SH, Hueng DY, Sytwu HK, Lin GJ. A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo. PLoS One. 2014 Aug 15;9(8):e104703. doi: 10.1371/journal.pone.0104703. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e113703. PubMed PMID: 25127132; PubMed Central PMCID: PMC4134221.

5: Chang YL, Lee HJ, Liu ST, Lin YS, Chen TC, Hsieh TY, Huang HS, Huang SM. Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin. Int J Biochem Cell Biol. 2011 Dec;43(12):1720-8. doi: 10.1016/j.biocel.2011.08.006. Epub 2011 Aug 12. PubMed PMID: 21856437.

6: Huang HS, Chen TC, Chen RH, Huang KF, Huang FC, Jhan JR, Chen CL, Lee CC, Lo Y, Lin JJ. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009 Nov 1;17(21):7418-28. doi: 10.1016/j.bmc.2009.09.033. Epub 2009 Sep 23. PubMed PMID: 19804981.