Oxyphenisatin Acetate
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MedKoo CAT#: 571543

CAS#: 115-33-3

Description: Oxphenisatin Acetate inhibits the growth of breast cancer cells by inhibiting translation, rapid phosphorylation. The pathways involved in apoptosis induction, starvation responses, and RNA/protein metabolism. Oxphenisatin Acetate also results in mitochondrial dysfunction.


Chemical Structure

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Oxyphenisatin Acetate
CAS# 115-33-3

Theoretical Analysis

MedKoo Cat#: 571543
Name: Oxyphenisatin Acetate
CAS#: 115-33-3
Chemical Formula: C24H19NO5
Exact Mass: 401.13
Molecular Weight: 401.42
Elemental Analysis: C, 71.81; H, 4.77; N, 3.49; O, 19.93

Price and Availability

Size Price Availability Quantity
250.0mg USD 220.0 2 Weeks
1.0g USD 380.0 2 Weeks
5.0g USD 720.0 2 Weeks
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Synonym: Acetophenolisatin; NSC 117186; NSC-117186; NSC117186; NSC 59687; NSC-59687; NSC59687

IUPAC/Chemical Name: 2-Indolinone, 3,3-bis(p-hydroxyphenyl)-, diacetate

InChi Key: PHPUXYRXPHEJDF-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28)

SMILES Code: O=C1NC2=C(C=CC=C2)C1(C3=CC=C(OC(C)=O)C=C3)C4=CC=C(OC(C)=O)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Morrison BL, Mullendore ME, Stockwin LH, Borgel S, Hollingshead MG, Newton DL. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700. doi: 10.1002/cam4.107. Epub 2013 Jul 23. PubMed PMID: 24403234; PubMed Central PMCID: PMC3892800.

2: Trojel-Hansen C, Erichsen KD, Christensen MK, Jensen PB, Sehested M, Nielsen SJ. Novel small molecule drugs inhibit tumor cell metabolism and show potent anti-tumorigenic potential. Cancer Chemother Pharmacol. 2011 Jul;68(1):127-38. doi: 10.1007/s00280-010-1453-3. Epub 2010 Sep 18. PubMed PMID: 20852860.

3: Uddin MK, Reignier SG, Coulter T, Montalbetti C, Grånäs C, Butcher S, Krog-Jensen C, Felding J. Syntheses and antiproliferative evaluation of oxyphenisatin derivatives. Bioorg Med Chem Lett. 2007 May 15;17(10):2854-7. Epub 2007 Feb 25. PubMed PMID: 17368900.

4: Teh LB, Chong R, Ho JM, Ong YY. Oxyphenisatin induced chronic active hepatitis--a potential health hazard in Singapore. Singapore Med J. 1988 Oct;29(5):508-12. PubMed PMID: 3241981.

5: Bercetche M, Pérez V, Avaginina A. [Chronic hepatitis caused by oxyphenisatin]. Medicina (B Aires). 1984;44(1):59-63. Spanish. PubMed PMID: 6549524.

6: Farack UM, Nell G. Mechanism of action of diphenolic laxatives: the role of adenylate cyclase and mucosal permeability. Digestion. 1984;30(3):191-4. PubMed PMID: 6548720.

7: Farack UM, Nell G, Rummel W. Differentiation of secretagogue drugs by chlorpromazine in rat intestine in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(1):70-4. PubMed PMID: 6688858.

8: Valerdiz Casasola S, Linares Rodríguez A, Recarte Alvarez J, Rodrigo Sáez L. [Hepatitis caused by drugs. 5]. Rev Esp Enferm Apar Dig. 1982 Nov;62(5):431-44. Review. Spanish. PubMed PMID: 6762631.

9: Sund RB, Hillestad B. Uptake, conjugation and transport of laxative diphenols by everted sacs of the rat jejunum and stripped colon. Acta Pharmacol Toxicol (Copenh). 1982 Oct;51(4):377-87. PubMed PMID: 6897480.

10: Bergan T, Fotland MH, Sund RB. Interaction between diphenolic laxatives and intestinal bacteria in vitro. Acta Pharmacol Toxicol (Copenh). 1982 Aug;51(2):165-72. PubMed PMID: 6896788.

11: Døssing M, Andreasen PB. Drug-induced liver disease in Denmark. An analysis of 572 cases of hepatotoxicity reported to the Danish Board of Adverse Reactions to Drugs. Scand J Gastroenterol. 1982 Mar;17(2):205-11. PubMed PMID: 6982502.

12: Irwin JP, Peterson GH. Colon preparation for the barium enema: a guide for the radiologist. Gastrointest Radiol. 1982;7(1):75-8. PubMed PMID: 6174383.

13: de Wolff FA, de Haas EJ, Verweij M. A screening method for establishing laxative abuse. Clin Chem. 1981 Jun;27(6):914-7. PubMed PMID: 6894566.

14: Seeff LB. Drug-induced chronic liver disease, with emphasis on chronic active hepatitis. Semin Liver Dis. 1981 May;1(2):104-15. Review. PubMed PMID: 7051296.

15: Kok RM, Faber DB. Qualitative and quantitative analysis of some synthetic, chemically acting laxatives in urine by gas chromatography-mass spectrometry. J Chromatogr. 1981 Mar 13;222(3):389-98. PubMed PMID: 6894448.

16: Nishikawa J. Effects of sodium picosulfate and other laxatives in cultured Chang cells. Arzneimittelforschung. 1981;31(11):1872-5. PubMed PMID: 7198466.

17: Minker E, Matejka Z. Purinergic reflex activated by cathartics in the rat. Acta Physiol Acad Sci Hung. 1981;57(1):99-107. PubMed PMID: 6895147.

18: Kotha P, Rake MO, Willatt D. Liver damage induced by oxyphenisatin. Br Med J. 1980 Dec 6;281(6254):1530. PubMed PMID: 6893676; PubMed Central PMCID: PMC1714947.

19: Wright R. Drug-induced chronic hepatitis. Springer Semin Immunopathol. 1980 Dec;3(3):331-8. Review. PubMed PMID: 7022714.

20: Guillausseau PJ, Guillausseau C, Cywiner-Golenzer C, Warner A, Kaloustian E, Galian A, Lubetzki J. [Oxypenisatin hepatotoxicity--a new case? (author's transl)]. Nouv Presse Med. 1980 Nov 15;9(43):3282. French. PubMed PMID: 6893863.