Oxyphenisatin Acetate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571543

CAS#: 115-33-3

Description: Oxphenisatin Acetate inhibits the growth of breast cancer cells by inhibiting translation, rapid phosphorylation. The pathways involved in apoptosis induction, starvation responses, and RNA/protein metabolism. Oxphenisatin Acetate also results in mitochondrial dysfunction.

Chemical Structure

Oxyphenisatin Acetate
CAS# 115-33-3

Theoretical Analysis

MedKoo Cat#: 571543
Name: Oxyphenisatin Acetate
CAS#: 115-33-3
Chemical Formula: C24H19NO5
Exact Mass: 401.13
Molecular Weight: 401.42
Elemental Analysis: C, 71.81; H, 4.77; N, 3.49; O, 19.93

Price and Availability

Size Price Availability Quantity
250.0mg USD 220.0 2 Weeks
1.0g USD 380.0 2 Weeks
5.0g USD 720.0 2 Weeks
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Synonym: Acetophenolisatin; NSC 117186; NSC-117186; NSC117186; NSC 59687; NSC-59687; NSC59687

IUPAC/Chemical Name: 2-Indolinone, 3,3-bis(p-hydroxyphenyl)-, diacetate


InChi Code: InChI=1S/C24H19NO5/c1-15(26)29-19-11-7-17(8-12-19)24(18-9-13-20(14-10-18)30-16(2)27)21-5-3-4-6-22(21)25-23(24)28/h3-14H,1-2H3,(H,25,28)

SMILES Code: O=C1NC2=C(C=CC=C2)C1(C3=CC=C(OC(C)=O)C=C3)C4=CC=C(OC(C)=O)C=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 401.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Morrison BL, Mullendore ME, Stockwin LH, Borgel S, Hollingshead MG, Newton DL. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy, mitochondrial dysfunction, and autocrine TNFα-mediated apoptosis. Cancer Med. 2013 Oct;2(5):687-700. doi: 10.1002/cam4.107. Epub 2013 Jul 23. PubMed PMID: 24403234; PubMed Central PMCID: PMC3892800.

2: Trojel-Hansen C, Erichsen KD, Christensen MK, Jensen PB, Sehested M, Nielsen SJ. Novel small molecule drugs inhibit tumor cell metabolism and show potent anti-tumorigenic potential. Cancer Chemother Pharmacol. 2011 Jul;68(1):127-38. doi: 10.1007/s00280-010-1453-3. Epub 2010 Sep 18. PubMed PMID: 20852860.

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