WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562653
Description: VU0453379 is a CNS-penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM).
MedKoo Cat#: 562653
Chemical Formula: C26H34N4O2
Exact Mass: 434.2682
Molecular Weight: 434.58
Elemental Analysis: C, 71.86; H, 7.89; N, 12.89; O, 7.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: VU0453379; VU-0453379; VU 0453379;
IUPAC/Chemical Name: (S)-2-Cyclopentyl-9-methyl-1-oxo-2,9-dihydro-1H-b-carboline-4-carboxylic acid (1-isopropyl-pyrrolidin-2-ylmethyl)-amide
InChi Key: OEYYOVRNPJSWTO-IBGZPJMESA-N
InChi Code: InChI=1S/C26H34N4O2/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31)/t19-/m0/s1
SMILES Code: O=C(C(C1=C2N(C)C3=C1C=CC=C3)=CN(C4CCCC4)C2=O)NC[C@H]5N(C(C)C)CCC5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 434.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Morris LC, Nance KD, Gentry PR, Days EL, Weaver CD, Niswender CM, Thompson AD, Jones CK, Locuson CW, Morrison RD, Daniels JS, Niswender KD, Lindsley CW. Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-py rrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM). J Med Chem. 2014 Dec 11;57(23):10192-7. doi: 10.1021/jm501375c. Epub 2014 Dec 2. PubMed PMID: 25423411; PubMed Central PMCID: PMC4266362.