WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562616
CAS#: 548779-60-8
Description: IHR-1 is a cell-membrane-impermeable Smo antagonist.
MedKoo Cat#: 562616
Name: IHR-1
CAS#: 548779-60-8
Chemical Formula: C20H12Cl4N2O2
Exact Mass: 451.9653
Molecular Weight: 454.12
Elemental Analysis: C, 52.90; H, 2.66; Cl, 31.22; N, 6.17; O, 7.05
Related CAS #: 548779-60-8
Synonym: IHR-1; IHR 1; IHR1;
IUPAC/Chemical Name: N,N'-(1,4-phenylene)bis(2,5-dichlorobenzamide)
InChi Key: VCLHHRGZKNUOAQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H12Cl4N2O2/c21-11-1-7-17(23)15(9-11)19(27)25-13-3-5-14(6-4-13)26-20(28)16-10-12(22)2-8-18(16)24/h1-10H,(H,25,27)(H,26,28)
SMILES Code: ClC1=C(C(NC2=CC=C(NC(C3=CC(Cl)=CC=C3Cl)=O)C=C2)=O)C=C(Cl)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 454.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L. The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem Biol. 2014 Dec 18;21(12):1680-9. doi: 10.1016/j.chembiol.2014.10.013. Epub 2014 Dec 4. Erratum in: Chem Biol. 2015 Apr 23;22(4):559. PubMed PMID: 25484239; PubMed Central PMCID: PMC4272670.
