WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 571663
CAS#: 1428629-70-2
Description: Propargyl-PEG4-NHS ester is a PEG derivative containing a propargyl group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. This reagent has a terminal NHS ester and is an amine reactive reagent for derivatizing peptides, antibodies, amine coated surfaces etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-NHS ester Click Chemistry to yield a stable triazole linkage.
MedKoo Cat#: 571663
Name: Propargyl-PEG4-NHS ester
CAS#: 1428629-70-2
Chemical Formula: C16H23NO8
Exact Mass: 357.1424
Molecular Weight: 357.36
Elemental Analysis: C, 53.78; H, 6.49; N, 3.92; O, 35.82
Synonym: Propargyl-PEG4-NHS ester
IUPAC/Chemical Name: Propargyl-PEG4-NHS ester
InChi Key: WMBISYJCYQJEQK-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H19O6.C4H4NO2/c1-2-4-15-6-8-17-10-11-18-9-7-16-5-3-12(13)14;6-3-1-2-4(7)5-3/h1H,3-11H2;1-2H2
SMILES Code: [O]C(CCOCCOCCOCCOCC#C)=O.O=C1[N]C(CC1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 357.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.
