Nitroxylene

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341482

CAS#: 25168-04-1

Description: Nitroxylene is a biochemical.

Chemical Structure

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Nitroxylene
CAS# 25168-04-1
Instruction

Theoretical Analysis

MedKoo Cat#: 341482
Name: Nitroxylene
CAS#: 25168-04-1
Chemical Formula: C8H9NO2
Exact Mass: 151.06
Molecular Weight: 151.165
Elemental Analysis: C, 63.56; H, 6.00; N, 9.27; O, 21.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Nitroxylene;

IUPAC/Chemical Name: Xylene, ar-nitro-

InChi Key: FVHAWXWFPBPFOS-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H9NO2/c1-6-4-3-5-8(7(6)2)9(10)11/h3-5H,1-2H3

SMILES Code: Cc1cccc(c1C)[N+](=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 151.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Srivastava D, Favez O, Bonnaire N, Lucarelli F, Haeffelin M, Perraudin E, Gros V, Villenave E, Albinet A. Speciation of organic fractions does matter for aerosol source apportionment. Part 2: Intensive short-term campaign in the Paris area (France). Sci Total Environ. 2018 Apr 5;634:267-278. doi: 10.1016/j.scitotenv.2018.03.296. [Epub ahead of print] PubMed PMID: 29627550.

2: Wheelock K, Zhang JJ, McConnell R, Tang D, Volk HE, Wang Y, Herbstman JB, Wang S, Phillips DH, Camann D, Gong J, Perera F. A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environ Sci Process Impacts. 2018 Mar 21. doi: 10.1039/C7EM00522A. [Epub ahead of print] PubMed PMID: 29561551.

3: Walter M, Kravchyk KV, Böfer C, Widmer R, Kovalenko MV. Polypyrenes as High-Performance Cathode Materials for Aluminum Batteries. Adv Mater. 2018 Apr;30(15):e1705644. doi: 10.1002/adma.201705644. Epub 2018 Mar 7. PubMed PMID: 29512211.

4: Riley EA, Carpenter EE, Ramsay J, Zamzow E, Pyke C, Paulsen MH, Sheppard L, Spear TM, Seixas NS, Stephenson DJ, Simpson CD. Evaluation of 1-Nitropyrene as a Surrogate Measure for Diesel Exhaust. Ann Work Expo Health. 2018 Mar 12;62(3):339-350. doi: 10.1093/annweh/wxx111. PubMed PMID: 29300809; PubMed Central PMCID: PMC5873526.

5: Hayakawa K, Tang N, Nagato EG, Toriba A, Sakai S, Kano F, Goto S, Endo O, Arashidani KI, Kakimoto H. Long term trends in atmospheric concentrations of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons: A study of Japanese cities from 1997 to 2014. Environ Pollut. 2018 Feb;233:474-482. doi: 10.1016/j.envpol.2017.10.038. Epub 2017 Nov 5. PubMed PMID: 29101890.

6: Li X, Yang H, Sun H, Lu R, Zhang C, Gao N, Meng Q, Wu S, Wang S, Aschner M, Wu J, Tang B, Gu A, Kay SA, Chen R. Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9655-E9664. doi: 10.1073/pnas.1712465114. Epub 2017 Oct 25. PubMed PMID: 29078374; PubMed Central PMCID: PMC5692577.

7: Yagi T, Fujikawa Y, Sawai T, Takamura-Enya T, Ito-Harashima S, Kawanishi M. Error-Prone and Error-Free Translesion DNA Synthesis over Site-Specifically Created DNA Adducts of Aryl Hydrocarbons (3-Nitrobenzanthrone and 4-Aminobiphenyl). Toxicol Res. 2017 Oct;33(4):265-272. doi: 10.5487/TR.2017.33.4.265. Epub 2015 Oct 15. Review. PubMed PMID: 29071010; PubMed Central PMCID: PMC5654197.

8: Birolli WG, de A Santos D, Alvarenga N, Garcia ACFS, Romão LPC, Porto ALM. Biodegradation of anthracene and several PAHs by the marine-derived fungus Cladosporium sp. CBMAI 1237. Mar Pollut Bull. 2018 Apr;129(2):525-533. doi: 10.1016/j.marpolbul.2017.10.023. Epub 2017 Oct 18. PubMed PMID: 29055563.

9: de Oliveira Galvão MF, de Oliveira Alves N, Ferreira PA, Caumo S, de Castro Vasconcellos P, Artaxo P, de Souza Hacon S, Roubicek DA, Batistuzzo de Medeiros SR. Biomass burning particles in the Brazilian Amazon region: Mutagenic effects of nitro and oxy-PAHs and assessment of health risks. Environ Pollut. 2018 Feb;233:960-970. doi: 10.1016/j.envpol.2017.09.068. Epub 2017 Oct 12. PubMed PMID: 29031407.

10: Yang X, Liu S, Xu Y, Liu Y, Chen L, Tang N, Hayakawa K. Emission factors of polycyclic and nitro-polycyclic aromatic hydrocarbons from residential combustion of coal and crop residue pellets. Environ Pollut. 2017 Dec;231(Pt 2):1265-1273. doi: 10.1016/j.envpol.2017.08.087. Epub 2017 Sep 22. PubMed PMID: 28947317.

11: Orakij W, Chetiyanukornkul T, Chuesaard T, Kaganoi Y, Uozaki W, Homma C, Boongla Y, Tang N, Hayakawa K, Toriba A. Personal inhalation exposure to polycyclic aromatic hydrocarbons and their nitro-derivatives in rural residents in northern Thailand. Environ Monit Assess. 2017 Sep 18;189(10):510. doi: 10.1007/s10661-017-6220-z. PubMed PMID: 28924862.

12: Li R, Zhao L, Zhang L, Chen M, Dong C, Cai Z. DNA damage and repair, oxidative stress and metabolism biomarker responses in lungs of rats exposed to ambient atmospheric 1-nitropyrene. Environ Toxicol Pharmacol. 2017 Sep;54:14-20. doi: 10.1016/j.etap.2017.06.009. Epub 2017 Jun 20. PubMed PMID: 28668703.

13: Shang Y, Zhou Q, Wang T, Jiang Y, Zhong Y, Qian G, Zhu T, Qiu X, An J. Airborne nitro-PAHs induce Nrf2/ARE defense system against oxidative stress and promote inflammatory process by activating PI3K/Akt pathway in A549 cells. Toxicol In Vitro. 2017 Oct;44:66-73. doi: 10.1016/j.tiv.2017.06.017. Epub 2017 Jun 17. PubMed PMID: 28633978.

14: Olivas-Quintero S, López-Angulo G, Montes-Avila J, Díaz-Camacho SP, Vega-Aviña R, López-Valenzuela JÁ, Salazar-Salas NY, Delgado-Vargas F. Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis. Pharm Biol. 2017 Dec;55(1):1473-1482. doi: 10.1080/13880209.2017.1306712. PubMed PMID: 28347185.

15: Deng K, Chan W. Development of a QuEChERS-Based Method for Determination of Carcinogenic 2-Nitrofluorene and 1-Nitropyrene in Rice Grains and Vegetables: A Comparative Study with Benzo[a]pyrene. J Agric Food Chem. 2017 Mar 8;65(9):1992-1999. doi: 10.1021/acs.jafc.7b00051. Epub 2017 Feb 23. PubMed PMID: 28215082.

16: Bacolod ET, Uno S, Villamor SS, Koyama J. Oxidative stress and genotoxicity biomarker responses in tilapia (Oreochromis niloticus) exposed to environmental concentration of 1-nitropyrene. Mar Pollut Bull. 2017 Nov 30;124(2):786-791. doi: 10.1016/j.marpolbul.2017.01.077. Epub 2017 Feb 6. PubMed PMID: 28185655.

17: Miller-Schulze JP, Paulsen M, Kameda T, Toriba A, Hayakawa K, Cassidy B, Naeher L, Villalobos MA, Simpson CD. Nitro-PAH exposures of occupationally-exposed traffic workers and associated urinary 1-nitropyrene metabolite concentrations. J Environ Sci (China). 2016 Nov;49:213-221. doi: 10.1016/j.jes.2016.06.007. Epub 2016 Jul 4. PubMed PMID: 28007177.

18: Onduka T, Ojima D, Ito K, Mochida K, Ito M, Koyama J, Fujii K. Photo-induced toxicity and oxidative stress responses in Tigriopus japonicus exposed to nitro-polycyclic aromatic hydrocarbons and artificial light. Chemosphere. 2017 Feb;169:596-603. doi: 10.1016/j.chemosphere.2016.11.113. Epub 2016 Nov 27. PubMed PMID: 27902966.

19: Wang C, Yang J, Zhu L, Yan L, Lu D, Zhang Q, Zhao M, Li Z. Never deem lightly the "less harmful" low-molecular-weight PAH, NPAH, and OPAH - Disturbance of the immune response at real environmental levels. Chemosphere. 2017 Feb;168:568-577. doi: 10.1016/j.chemosphere.2016.11.024. Epub 2016 Nov 9. PubMed PMID: 27838030.

20: Cervena T, Rossnerova A, Sikorova J, Beranek V, Vojtisek-Lom M, Ciganek M, Topinka J, Rossner P Jr. DNA Damage Potential of Engine Emissions Measured In Vitro by Micronucleus Test in Human Bronchial Epithelial Cells. Basic Clin Pharmacol Toxicol. 2017 Sep;121 Suppl 3:102-108. doi: 10.1111/bcpt.12693. Epub 2017 Jan 6. PubMed PMID: 27782363.