NB-001
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MedKoo CAT#: 584422

CAS#: 686301-48-4

Description: NB-001 is an analgesic that can be used to treat bone cancer pain partially due to the inhibition of AC1 in anterior cingulate cortex.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 240 2 Weeks
25mg USD 690 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-08. Prices are subject to change without notice.

NB-001, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584422
Name: NB-001
CAS#: 686301-48-4
Chemical Formula: C12H20N6O
Exact Mass: 264.1699
Molecular Weight: 264.333
Elemental Analysis: C, 54.53; H, 7.63; N, 31.79; O, 6.05


Synonym: HTS 09836; HTS-09836; HTS09836; NB-001; NB001; NB 001

IUPAC/Chemical Name: 1-Pentanol, 5-((2-(6-amino-9H-purin-9-yl)ethyl)amino)-

InChi Key: CVPTTZZCRDVGSU-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H20N6O/c13-11-10-12(16-8-15-11)18(9-17-10)6-5-14-4-2-1-3-7-19/h8-9,14,19H,1-7H2,(H2,13,15,16)

SMILES Code: OCCCCCNCCN1C=NC2=C(N)N=CN=C12


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Bosse KE, Oginsky MF, Susick LL, Ramalingam S, Ferrario CR, Conti AC. Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum. J Pharmacol Exp Ther. 2017 Nov;363(2):148-155. doi: 10.1124/jpet.117.242321. Epub 2017 Aug 24. PubMed PMID: 28838956; PubMed Central PMCID: PMC5625283.

2: Sethna F, Feng W, Ding Q, Robison AJ, Feng Y, Wang H. Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model. Nat Commun. 2017 Feb 20;8:14359. doi: 10.1038/ncomms14359. PubMed PMID: 28218269; PubMed Central PMCID: PMC5321753.

3: Kang WB, Yang Q, Guo YY, Wang L, Wang DS, Cheng Q, Li XM, Tang J, Zhao JN, Liu G, Zhuo M, Zhao MG. Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model. Mol Pain. 2016 Sep 9;12. pii: 1744806916652409. doi: 10.1177/1744806916652409. Print 2016. PubMed PMID: 27612915; PubMed Central PMCID: PMC5019365.

4: Klotz KN, Kachler S. Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):349-52. doi: 10.1007/s00210-015-1197-z. Epub 2015 Dec 14. PubMed PMID: 26660072.

5: Tian Z, Wang DS, Wang XS, Tian J, Han J, Guo YY, Feng B, Zhang N, Zhao MG, Liu SB. Analgesic effects of NB001 on mouse models of arthralgia. Mol Brain. 2015 Oct 9;8(1):60. doi: 10.1186/s13041-015-0151-9. PubMed PMID: 26452469; PubMed Central PMCID: PMC4599030.

6: Chen T, O'Den G, Song Q, Koga K, Zhang MM, Zhuo M. Adenylyl cyclase subtype 1 is essential for late-phase long term potentiation and spatial propagation of synaptic responses in the anterior cingulate cortex of adult mice. Mol Pain. 2014 Oct 10;10:65. doi: 10.1186/1744-8069-10-65. PubMed PMID: 25304256; PubMed Central PMCID: PMC4198686.

7: Zhang MM, Liu SB, Chen T, Koga K, Zhang T, Li YQ, Zhuo M. Effects of NB001 and gabapentin on irritable bowel syndrome-induced behavioral anxiety and spontaneous pain. Mol Brain. 2014 Jun 16;7:47. doi: 10.1186/1756-6606-7-47. PubMed PMID: 24935250; PubMed Central PMCID: PMC4071154.

8: Brand CS, Hocker HJ, Gorfe AA, Cavasotto CN, Dessauer CW. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75. doi: 10.1124/jpet.113.208157. Epub 2013 Sep 4. PubMed PMID: 24006339; PubMed Central PMCID: PMC3807061.

9: Zhuo M. Targeting neuronal adenylyl cyclase for the treatment of chronic pain. Drug Discov Today. 2012 Jun;17(11-12):573-82. doi: 10.1016/j.drudis.2012.01.009. Epub 2012 Jan 26. Review. PubMed PMID: 22405897.

10: Li M, Cui J, Wang J, Wang J, Hao L. Isolation of nitrobenzene degrading strain Pseudomonas NB001 and application in the bioremediation of polluted water body. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2012;47(1):70-6. doi: 10.1080/10934529.2012.629583. PubMed PMID: 22217084.

11: Wang H, Xu H, Wu LJ, Kim SS, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med. 2011 Jan 12;3(65):65ra3. doi: 10.1126/scitranslmed.3001269. PubMed PMID: 21228397.

12: Tanigawa M, Sawada T. Effects of subminimal inhibitory concentrations of amoxicillin against Actinobacillus pleuropneumoniae. J Vet Med B Infect Dis Vet Public Health. 2002 Dec;49(10):513-8. PubMed PMID: 12485363.