WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562596
CAS#: 612530-44-6
Description: PTP1B-IN-1 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B).
MedKoo Cat#: 562596
Name: PTP1B-IN-1
CAS#: 612530-44-6
Chemical Formula: C8H8N2O3S
Exact Mass: 212.02
Molecular Weight: 212.22
Elemental Analysis: C, 45.28; H, 3.80; N, 13.20; O, 22.62; S, 15.11
Synonym: PTP1B-IN-1; PTP1B IN 1; PTP1BIN1; PTP1B inhibitor 1; PTP1B-inhibitor-1;
IUPAC/Chemical Name: 1,1-Dioxo-5-phenyl-1,2,5-thiadiazolidin-3-one
InChi Key: LDCZCUKQWRZSDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H8N2O3S/c11-8-6-10(14(12,13)9-8)7-4-2-1-3-5-7/h1-5H,6H2,(H,9,11)
SMILES Code: O=C(CN1C2=CC=CC=C2)NS1(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 212.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tan XF, Uddin Z, Park C, Song YH, Son M, Lee KW, Park KH. Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism. Bioorg Med Chem. 2017 Apr 15;25(8):2498-2506. doi: 10.1016/j.bmc.2017.03.010. Epub 2017 Mar 6. PubMed PMID: 28318895.
2: Tang YB, Lu D, Chen Z, Hu C, Yang Y, Tian JY, Ye F, Wu L, Zhang ZY, Xiao Z. Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors. Bioorg Med Chem Lett. 2013 Apr 15;23(8):2313-8. doi: 10.1016/j.bmcl.2013.02.073. Epub 2013 Feb 26. PubMed PMID: 23499238.
3: Zhao Y, Tan Y, Dai J, Wang B, Li B, Guo L, Cui J, Wang G, Li W, Cai L. Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3. J Nutr Biochem. 2012 Aug;23(8):1018-26. doi: 10.1016/j.jnutbio.2011.05.011. Epub 2011 Oct 13. PubMed PMID: 22000581.
4: Meshkani R, Adeli K. Hepatic insulin resistance, metabolic syndrome and cardiovascular disease. Clin Biochem. 2009 Sep;42(13-14):1331-46. doi: 10.1016/j.clinbiochem.2009.05.018. Epub 2009 Jun 6. Review. PubMed PMID: 19501581.
5: Du L, Shen L, Yu Z, Chen J, Guo Y, Tang Y, Shen X, Jiang H. Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site. ChemMedChem. 2008 Jan;3(1):173-80. PubMed PMID: 17943714.
6: Sparks RB, Polam P, Zhu W, Crawley ML, Takvorian A, McLaughlin E, Wei M, Ala PJ, Gonneville L, Taylor N, Li Y, Wynn R, Burn TC, Liu PC, Combs AP. Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):736-40. Epub 2006 Oct 28. PubMed PMID: 17097290.
7: Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW. Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age. Endocrinology. 2007 Jan;148(1):433-40. Epub 2006 Oct 12. PubMed PMID: 17038557; PubMed Central PMCID: PMC2596872.
8: Zhao H, Liu G, Xin Z, Serby MD, Pei Z, Szczepankiewicz BG, Hajduk PJ, Abad-Zapatero C, Hutchins CW, Lubben TH, Ballaron SJ, Haasch DL, Kaszubska W, Rondinone CM, Trevillyan JM, Jirousek MR. Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5543-6. PubMed PMID: 15482920.
