DSS-d4 Deuterated Crosslinker
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571633

CAS#: NONE

Description: DSS-d4 Deuterated Crosslinker, or Bis[Succinimidyl] 2,2,7,7-suberate-d4 is a cell membrane permeable crosslinking agent with 4 deuterium atoms that provide a 4 dalton shift by mass spectrometry analysis.

Chemical Structure

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DSS-d4 Deuterated Crosslinker
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 571633
Name: DSS-d4 Deuterated Crosslinker
CAS#: NONE
Chemical Formula: C16H16D4N2O8
Exact Mass: 372.15
Molecular Weight: 372.370
Elemental Analysis: C, 51.61; H, 6.49; N, 7.52; O, 34.37

Price and Availability

Size Price Availability Quantity
50mg USD 950 2 weeks
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Synonym: DSS-d4 Deuterated Crosslinker

IUPAC/Chemical Name: Suberic acid-2,2,7,7-d4 bis (N-hydroxysuccinimide ester)

InChi Key: ZWIBGKZDAWNIFC-NZLXMSDQSA-N

InChi Code: InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2/i5D2,6D2

SMILES Code: O=C(ON1C(CCC1=O)=O)C([2H])([2H])CCCCC([2H])([2H])C(ON2C(CCC2=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Use heavy DSS-d4 crosslinker in combination with DSS crosslinking reagent (the light, non-deuterated analog, DSS-d0) for mass spec studies.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 372.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Haladová K, Mrázek H, Ječmen T, Halada P, Man P, Novák P, Chmelík J, Obšil T, Šulc M. The combination of hydrogen/deuterium exchange or chemical cross-linking techniques with mass spectrometry: mapping of human 14-3-3ζ homodimer interface. J Struct Biol. 2012 Jul;179(1):10-7. doi: 10.1016/j.jsb.2012.04.016. Epub 2012 May 2. PubMed PMID: 22580067.