Xorphanol mesylate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341454

CAS#: 77287-90-2

Description: Xorphanol mesylate is a biochemical.


Chemical Structure

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Xorphanol mesylate
CAS# 77287-90-2

Theoretical Analysis

MedKoo Cat#: 341454
Name: Xorphanol mesylate
CAS#: 77287-90-2
Chemical Formula: C24H35NO4S
Exact Mass: 433.23
Molecular Weight: 433.607
Elemental Analysis: C, 66.48; H, 8.14; N, 3.23; O, 14.76; S, 7.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Xorphanol mesylate; TR-5379M; TR 5379M; TR5379M.

IUPAC/Chemical Name: Morphinan-3-ol, 17-(cyclobutylmethyl)-6-methylene-, (8-beta)-, methanesulfonate

InChi Key: VRWTWCLVCNQJGM-ZBWZZBALSA-N

InChi Code: InChI=1S/C23H31NO.CH4O3S/c1-15-10-16(2)22-21-11-18-6-7-19(25)12-20(18)23(22,13-15)8-9-24(21)14-17-4-3-5-17;1-5(2,3)4/h6-7,12,16-17,21-22,25H,1,3-5,8-11,13-14H2,2H3;1H3,(H,2,3,4)/t16-,21+,22-,23+;/m0./s1

SMILES Code: C[C@H]1CC(=C)C[C@]23CCN(CC4CCC4)[C@H](Cc5ccc(O)cc25)[C@H]13.CS(=O)(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 433.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Howes JF, Villarreal JE, Harris LS, Essigmann EM, Cowan A. Xorphanol. Drug Alcohol Depend. 1985 Feb;14(3-4):373-80. PubMed PMID: 4039650.

2: McCarthy PS, Howlett GJ. Physical dependence induced by opiate partial agonists in the rat. Neuropeptides. 1984 Dec;5(1-3):11-4. PubMed PMID: 6152317.

3: Porter MC, Hartnagel RE, Clemens GR, Kowalski RL, Bare JJ, Halliwell WE, Kitchen DN. Preclinical toxicity and teratogenicity studies with the narcotic antagonist analgesic drug TR5379M. Fundam Appl Toxicol. 1983 Sep-Oct;3(5):478-82. PubMed PMID: 6642105.

4: Howes JF, Bousquet AR. Development of TR5379M (xorphanol mesylate), an oral analgesic. NIDA Res Monogr. 1983 Apr;43:231-7. PubMed PMID: 6135994.

5: Polazzi JO, Kotick MP, Howes JF, Bousquet AR. Analgesic narcotic antagonists. 9. 6-Methylene-8 beta-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans. J Med Chem. 1981 Dec;24(12):1516-8. PubMed PMID: 6796691.