WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 341437
CAS#: 19179-88-5
Description: Xipranolol hydrochloride is a biochemical.
MedKoo Cat#: 341437
Name: Xipranolol hydrochloride
CAS#: 19179-88-5
Chemical Formula: C23H34ClNO2
Exact Mass: 391.2278
Molecular Weight: 391.98
Elemental Analysis: C, 70.48; H, 8.74; Cl, 9.04; N, 3.57; O, 8.16
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Xipranolol hydrochloride; BS-7977 D; BS 7977 D; BS7977 D.
IUPAC/Chemical Name: 1-(Bis(2,6-dimethylphenyl)methoxy)-3-(isopropylamino)-2-propanol hydrochloride
InChi Key: RQBVHSDIFWEDLD-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H33NO2.ClH/c1-15(2)24-13-20(25)14-26-23(21-16(3)9-7-10-17(21)4)22-18(5)11-8-12-19(22)6;/h7-12,15,20,23-25H,13-14H2,1-6H3;1H
SMILES Code: OC(CNC(C)C)COC(C1=C(C)C=CC=C1C)C2=C(C)C=CC=C2C.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 391.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mishra B, Sankar C, Mishra M. Polymer based solutions of bupranolol hydrochloride for intranasal systemic delivery. J Drug Target. 2011 Apr;19(3):204-11. doi: 10.3109/1061186X.2010.492520. Epub 2010 Jun 15. PubMed PMID: 20550434.
2: Matsushita M, Horinouchi T, Tanaka Y, Tsuru H, Koike K. Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle. Eur J Pharmacol. 2003 Dec 15;482(1-3):235-44. PubMed PMID: 14660028.
3: Horinouchi T, Koike K. Partial agonistic properties of (+/-)-pindolol at atypical beta-adrenoceptors in the guinea pig gastric fundus. Pharmacology. 2001;63(4):197-202. PubMed PMID: 11729357.
4: Danner I, Escande D, Gauthier C. Beta(3)-adrenoceptors control Cl(-) conductance in rabbit nasal epithelium. Eur J Pharmacol. 2001 Jun 22;422(1-3):203-7. PubMed PMID: 11430932.
5: Horinouchi T, Koike K. Functional properties of atypical beta-adrenoceptors on the guinea pig duodenum. Eur J Pharmacol. 2001 Mar 23;416(1-2):153-63. PubMed PMID: 11282125.
6: Horinouchi T, Koike K. (+/-)-Pindolol acts as a partial agonist at atypical beta-adrenoceptors in the guinea pig duodenum. Jpn J Pharmacol. 2001 Jan;85(1):35-40. PubMed PMID: 11243572.
7: Horinouchi T, Koike K. Partial agonistic effects of carteolol on atypical beta-adrenoceptors in the guinea pig gastric fundus. Jpn J Pharmacol. 2000 Nov;84(3):287-92. PubMed PMID: 11138729.
8: Horinouchi T, Koike K. Partial agonist activity of carteolol on atypical beta-adrenoceptors in the guinea pig duodenum. Eur J Pharmacol. 2000 Sep 1;403(1-2):133-8. PubMed PMID: 10969154.
9: Tomiyama Y, Hayakawa K, Shinagawa K, Akahane M, Ajisawa Y, Park YC, Kurita T. Beta-adrenoceptor subtypes in the ureteral smooth muscle of rats, rabbits and dogs. Eur J Pharmacol. 1998 Jul 10;352(2-3):269-78. PubMed PMID: 9716364.
10: Sarsero D, Molenaar P, Kaumann AJ. Validity of (-)-[3H]-CGP 12177A as a radioligand for the 'putative beta4-adrenoceptor' in rat atrium. Br J Pharmacol. 1998 Feb;123(3):371-80. PubMed PMID: 9504376; PubMed Central PMCID: PMC1565174.
11: Coruzzi G, Bertaccini G. The beta3-adrenoceptor agonist SR58611A inhibits gastric acid secretion in the conscious cat. Naunyn Schmiedebergs Arch Pharmacol. 1997 Aug;356(2):263-5. PubMed PMID: 9272734.
12: Carpéné C, Galitzky J, Collon P, Esclapez F, Dauzats M, Lafontan M. Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion. J Pharmacol Exp Ther. 1993 Apr;265(1):237-47. PubMed PMID: 8097243.
13: Satoh H, Endoh M. Effects of a new cardiotonic agent 1,2-dihydro-6-methyl-2-oxo-5-[imidazo (1,2-a) pyridin-6-yl]-3-pyridine carbonitrile hydrochloride monohydrate (E-1020) on contractile force and cyclic AMP metabolism in canine ventricular muscle. Jpn J Pharmacol. 1990 Feb;52(2):215-24. PubMed PMID: 2156096.
14: Murai T, Maejima T, Sanai K, Osada E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung. 1984;34(11A):1633-40. PubMed PMID: 6152156.
15: Takahashi N, Murota H, Sutoh I. Antimicrobial activity of topical beta-adrenergic blocking agents. Ophthalmic Res. 1983;15(6):277-9. PubMed PMID: 6142443.
16: Takahashi N. A new method evaluating quantitative time-dependent cytotoxicity of ophthalmic solutions in cell culture. Beta-adrenergic blocking agents. Graefes Arch Clin Exp Ophthalmol. 1983;220(6):264-7. PubMed PMID: 6138299.
17: Waller AR, Chasseaud LF, Bonn R, Taylor T, Darragh A, Girkin R, Down WH, Doyle E. Metabolic fate of the beta-blocker 14C-bupranolol in humans, dogs, and rhesus monkeys. Drug Metab Dispos. 1982 Jan-Feb;10(1):51-4. PubMed PMID: 6124383.
18: Tamura T, Osada E, Ueno K. [Effect of bupranolol hydrochloride (KL 255) on cyclic AMP level of aqueous humor, iris and ciliary body of albino rabbit (author's transl)]. Nippon Ganka Gakkai Zasshi. 1978 Jul 10;82(7):517-21. Japanese. PubMed PMID: 211836.
19: Placheta P, Singer E, Kraupp O. [Effect of the beta-adrenergic blocking agent bupranolol on the plasma renin activity in normotensive rats]. Arzneimittelforschung. 1977;27(11):2063-6. German. PubMed PMID: 23790.
