Naproxen sodium
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341417

CAS#: 26159-34-2

Description: Naproxen sodium is a non-steroidal anti-inflammatory drug (NSAID) which has been shown to reduce fever, swelling, and stiffness. It may be useful in the treatment of chronic inflammation.


Price and Availability

Size Price Shipping out time Quantity
5g USD 260 2 Weeks
50g USD 910 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

Naproxen sodium, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 341417
Name: Naproxen sodium
CAS#: 26159-34-2
Chemical Formula: C14H13NaO3
Exact Mass: 252.0762
Molecular Weight: 252.2448
Elemental Analysis: C, 66.66; H, 5.19; Na, 9.11; O, 19.03


Synonym: Naproxen sodium; RS 3650; RS-3650; RS3650; Sodium naproxen; Naproxen natrium

IUPAC/Chemical Name: 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-

InChi Key: CDBRNDSHEYLDJV-FVGYRXGTSA-M

InChi Code: InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

SMILES Code: O=C([O-])[C@@H](C)C1=CC=C2C=C(OC)C=CC2=C1.[Na+]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Acosta-Vélez GF, Zhu TZ, Linsley CS, Wu BM. Photocurable Poly(ethylene glycol) as a Bioink for the Inkjet 3D Pharming of Hydrophobic Drugs. Int J Pharm. 2018 Apr 26. pii: S0378-5173(18)30284-9. doi: 10.1016/j.ijpharm.2018.04.056. [Epub ahead of print] PubMed PMID: 29705105.

2: Zhao J, Levy D. Dissociation between CSD-evoked metabolic perturbations and meningeal afferent activation and sensitization: implications for mechanisms of migraine headache onset. J Neurosci. 2018 Apr 27. pii: 0115-18. doi: 10.1523/JNEUROSCI.0115-18.2018. [Epub ahead of print] PubMed PMID: 29703787.

3: See HH, Mamat NA, Hauser PC. Flow Injection Analysis with Direct UV Detection Following Electric Field Driven Membrane Extraction. Molecules. 2018 Apr 24;23(5). pii: E1000. doi: 10.3390/molecules23051000. PubMed PMID: 29695126.

4: Jevsevar DS, Shores PB, Mullen K, Schulte DM, Brown GA, Cummins DS. Mixed Treatment Comparisons for Nonsurgical Treatment of Knee Osteoarthritis: A Network Meta-analysis. J Am Acad Orthop Surg. 2018 May 1;26(9):325-336. doi: 10.5435/JAAOS-D-17-00318. PubMed PMID: 29688920.

5: Solomon DH, Libby P, Yeomans ND, Wang Q, Wolski KE, Nissen SE, Husni ME. The potential benefits of aspirin for primary cardiovascular prevention in rheumatoid arthritis: a secondary analysis of the PRECISION Trial. Rheumatology (Oxford). 2018 Apr 20. doi: 10.1093/rheumatology/key105. [Epub ahead of print] PubMed PMID: 29688503.

6: Al-Rashed F, Calay D, Lang M, Thornton CC, Bauer A, Kiprianos A, Haskard DO, Seneviratne A, Boyle JJ, Schönthal AH, Wheeler-Jones CP, Mason JC. Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling. Sci Rep. 2018 Apr 19;8(1):6271. doi: 10.1038/s41598-018-24548-z. PubMed PMID: 29674687; PubMed Central PMCID: PMC5908847.

7: Dubreuil M, Louie-Gao Q, Peloquin CE, Choi HK, Zhang Y, Neogi T. Risk of myocardial infarction with use of selected non-steroidal anti-inflammatory drugs in patients with spondyloarthritis and osteoarthritis. Ann Rheum Dis. 2018 Apr 19. pii: annrheumdis-2018-213089. doi: 10.1136/annrheumdis-2018-213089. [Epub ahead of print] PubMed PMID: 29674321.

8: Reed GW, Abdallah MS, Shao M, Wolski K, Wisniewski L, Yeomans N, Lüscher TF, Borer JS, Graham DY, Husni ME, Solomon DH, Libby P, Menon V, Lincoff AM, Nissen SE. Effect of Aspirin Coadministration on the Safety of Celecoxib, Naproxen, or Ibuprofen. J Am Coll Cardiol. 2018 Apr 24;71(16):1741-1751. doi: 10.1016/j.jacc.2018.02.036. PubMed PMID: 29673465.

9: Makunts T, Cohen IV, Lee KC, Abagyan R. Population scale retrospective analysis reveals distinctive antidepressant and anxiolytic effects of diclofenac, ketoprofen and naproxen in patients with pain. PLoS One. 2018 Apr 18;13(4):e0195521. doi: 10.1371/journal.pone.0195521. eCollection 2018. PubMed PMID: 29668764.

10: Yeomans ND, Graham DY, Husni ME, Solomon DH, Stevens T, Vargo J, Wang Q, Wisniewski LM, Wolski KE, Borer JS, Libby P, Lincoff AM, Lüscher TF, Bao W, Walker C, Nissen SE; PRECISION investigators. Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial. Aliment Pharmacol Ther. 2018 Apr 17. doi: 10.1111/apt.14610. [Epub ahead of print] PubMed PMID: 29667211.

11: Suzuki R, Fujita T, Mizuta K, Kumamoto E. Inhibition by non-steroidal anti-inflammatory drugs of compound action potentials in frog sciatic nerve fibers. Biomed Pharmacother. 2018 Apr 14;103:326-335. doi: 10.1016/j.biopha.2018.04.041. [Epub ahead of print] PubMed PMID: 29665554.

12: Shu C, Li T, Yang W, Li D, Ji S, Ding L. Amphotericin B-conjugated polypeptide hydrogels as a novel innovative strategy for fungal infections. R Soc Open Sci. 2018 Mar 14;5(3):171814. doi: 10.1098/rsos.171814. eCollection 2018 Mar. PubMed PMID: 29657786; PubMed Central PMCID: PMC5882710.

13: Kwak K, Ji K, Kho Y, Kim P, Lee J, Ryu J, Choi K. Chronic toxicity and endocrine disruption of naproxen in freshwater waterfleas and fish, and steroidogenic alteration using H295R cell assay. Chemosphere. 2018 Apr 7;204:156-162. doi: 10.1016/j.chemosphere.2018.04.035. [Epub ahead of print] PubMed PMID: 29655108.

14: Bhujbal SV, Zemlyanov DY, Cavallaro A, Mangal S, Taylor LS, Zhou QT. Qualitative and Quantitative Characterization of Composition Heterogeneity on the Surface of Spray Dried Amorphous Solid Dispersion Particles by an Advanced Surface Analysis Platform with High Surface Sensitivity and Superior Spatial Resolution. Mol Pharm. 2018 Apr 17. doi: 10.1021/acs.molpharmaceut.8b00122. [Epub ahead of print] PubMed PMID: 29641898.

15: Filimonov IS, Berzova AP, Barkhatov VI, Krivoshey AV, Trushkin NA, Vrzheshch PV. Negative Cooperativity in the Interaction of Prostaglandin H Synthase-1 with the Competitive Inhibitor Naproxen Can Be Described as the Interaction of a Non-competitive Inhibitor with Heterogeneous Enzyme Preparation. Biochemistry (Mosc). 2018 Feb;83(2):119-128. doi: 10.1134/S0006297918020049. PubMed PMID: 29618298.

16: Sharma M, Vadhariya A, Johnson ML, Marcum ZA, Holmes HM. Association between industry payments and prescribing costly medications: an observational study using open payments and medicare part D data. BMC Health Serv Res. 2018 Apr 2;18(1):236. doi: 10.1186/s12913-018-3043-8. PubMed PMID: 29609611; PubMed Central PMCID: PMC5880069.

17: Tai CH, Oh HB, Seet JE, Ngiam KY. Pseudogout - a rare manifestation of hungry bone syndrome after focused parathyroidectomy. Ann R Coll Surg Engl. 2018 May;100(5):e106-e108. doi: 10.1308/rcsann.2018.0028. Epub 2018 Apr 1. PubMed PMID: 29607728.

18: Malik P, Bhushan R. Enantioseparation of (RS)-fexofenadine and enhanced detection as the diastereomeric amide and anhydride derivatives using liquid chromatography-mass spectrometry. Biomed Chromatogr. 2018 Mar 30:e4217. doi: 10.1002/bmc.4217. [Epub ahead of print] PubMed PMID: 29601646.

19: Shamsayei M, Yamini Y, Asiabi H, Safari M. On-line packed magnetic in-tube solid phase microextraction of acidic drugs such as naproxen and indomethacin by using Fe(3)O(4)@SiO(2)@layered double hydroxide nanoparticles with high anion exchange capacity. Mikrochim Acta. 2018 Feb 22;185(3):192. doi: 10.1007/s00604-018-2716-7. PubMed PMID: 29594488.

20: Topolski F, Moro A, Correr GM, Schimim SC. Optimal management of orthodontic pain. J Pain Res. 2018 Mar 16;11:589-598. doi: 10.2147/JPR.S127945. eCollection 2018. Review. PubMed PMID: 29588616; PubMed Central PMCID: PMC5859910.