WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581199
Description: Dactylocyclines is novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.
MedKoo Cat#: 581199
Name: Dactylocycline A
Chemical Formula: C31H40ClN3O13
Exact Mass: 697.225
Molecular Weight: 698.12
Elemental Analysis: C, 53.33; H, 5.78; Cl, 5.08; N, 6.02; O, 29.79
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Synonym: Dactylocycline A; 0125622120;
IUPAC/Chemical Name: 7-chloro-4-(dimethylamino)-3,4a,10,12,12a-pentahydroxy-6-((4-(hydroxyamino)-5-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-methoxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
InChi Key: ZMMNIIAMYZOTAD-UHFFFAOYSA-N
InChi Code: CC1C(C(CC(O1)OC2(c3c(c(cc(c3Cl)OC)O)C(=O)C4=C(C5(C(=O)C(=C(C(C5(CC42)O)N(C)C)O)C(=O)N)O)O)C)(C)NO)OC
SMILES Code: CC1C(C(CC(O1)OC2(c3c(c(cc(c3Cl)OC)O)C(=O)C4=C(C5(C(=O)C(=C(C(C5(CC42)O)N(C)C)O)C(=O)N)O)O)C)(C)NO)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 698.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wang P, Kim W, Pickens LB, Gao X, Tang Y. Heterologous expression and manipulation of three tetracycline biosynthetic pathways. Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11136-40. doi: 10.1002/anie.201205426. Epub 2012 Sep 28. PubMed PMID: 23024027; PubMed Central PMCID: PMC4070387.
2: Devasthale PV, Mitscher LA, Telikepalli H, Vander Velde D, Zou JY, Ax HA, Tymiak AA. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. III. Absolute stereochemistry of the dactylocyclines. J Antibiot (Tokyo). 1992 Dec;45(12):1907-13. PubMed PMID: 1490882.
3: Wells JS, O'Sullivan J, Aklonis C, Ax HA, Tymiak AA, Kirsch DR, Trejo WH, Principe P. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. I. Taxonomy, production, isolation and biological activity. J Antibiot (Tokyo). 1992 Dec;45(12):1892-8. PubMed PMID: 1490880.
4: Tymiak AA, Ax HA, Bolgar MS, Kahle AD, Porubcan MA, Andersen NH. Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation. J Antibiot (Tokyo). 1992 Dec;45(12):1899-906. PubMed PMID: 1490881.