WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407904
Description: MS611 is a BET bromodomain inhbitor. MS611 showed 100-fold selectivity only for the BDs of the BRD4 bromodomain (Ki = 0.41 μM [BRD4-BD1]; 41.3 μM [BRD4-BD2]), while no or very small differences in affinity were observed between the two BDs of BRD2 and BRD3.
MedKoo Cat#: 407904
Chemical Formula: C21H18N4O3S
Exact Mass: 406.11
Molecular Weight: 406.46
Elemental Analysis: C, 62.06; H, 4.46; N, 13.78; O, 11.81; S, 7.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: MS611; MS-611; MS 611.
IUPAC/Chemical Name: (E)-N-(4-cyanophenyl)-4-((4-hydroxy-3,5-dimethylphenyl)diazenyl)benzenesulfonamide
InChi Key: XPACNVXDISGELS-WCWDXBQESA-N
InChi Code: InChI=1S/C21H18N4O3S/c1-14-11-19(12-15(2)21(14)26)24-23-17-7-9-20(10-8-17)29(27,28)25-18-5-3-16(13-22)4-6-18/h3-12,25-26H,1-2H3/b24-23+
SMILES Code: O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C(C)=C2)C=C1)(NC3=CC=C(C#N)C=C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 406.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Gacias M, Gerona-Navarro G, Plotnikov AN, Zhang G, Zeng L, Kaur J, Moy G,
Rusinova E, Rodriguez Y, Matikainen B, Vincek A, Joshua J, Casaccia P, Zhou MM.
Selective chemical modulation of gene transcription favors oligodendrocyte
lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854. doi:
10.1016/j.chembiol.2014.05.009. Epub 2014 Jun 19. PubMed PMID: 24954007; PubMed
Central PMCID: PMC4104156.
2. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain
Robert P. Law, Stephen J. Atkinson, Paul Bamborough, Chun-wa Chung, Emmanuel H. Demont, Laurie J. Gordon, Matthew Lindon, Rab K. Prinjha, Allan J. B. Watson, and David J. Hirst
Publication Date (Web): April 15, 2018 (Article)