MS611

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407904

CAS#: Unknown

Description: MS611 is a BET bromodomain inhbitor. MS611 showed 100-fold selectivity only for the BDs of the BRD4 bromodomain (Ki = 0.41 μM [BRD4-BD1]; 41.3 μM [BRD4-BD2]), while no or very small differences in affinity were observed between the two BDs of BRD2 and BRD3.


Chemical Structure

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MS611
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 407904
Name: MS611
CAS#: Unknown
Chemical Formula: C21H18N4O3S
Exact Mass: 406.11
Molecular Weight: 406.46
Elemental Analysis: C, 62.06; H, 4.46; N, 13.78; O, 11.81; S, 7.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: MS611; MS-611; MS 611.

IUPAC/Chemical Name: (E)-N-(4-cyanophenyl)-4-((4-hydroxy-3,5-dimethylphenyl)diazenyl)benzenesulfonamide

InChi Key: XPACNVXDISGELS-WCWDXBQESA-N

InChi Code: InChI=1S/C21H18N4O3S/c1-14-11-19(12-15(2)21(14)26)24-23-17-7-9-20(10-8-17)29(27,28)25-18-5-3-16(13-22)4-6-18/h3-12,25-26H,1-2H3/b24-23+

SMILES Code: O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C(C)=C2)C=C1)(NC3=CC=C(C#N)C=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 406.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gacias M, Gerona-Navarro G, Plotnikov AN, Zhang G, Zeng L, Kaur J, Moy G,
Rusinova E, Rodriguez Y, Matikainen B, Vincek A, Joshua J, Casaccia P, Zhou MM.
Selective chemical modulation of gene transcription favors oligodendrocyte
lineage progression. Chem Biol. 2014 Jul 17;21(7):841-854. doi:
10.1016/j.chembiol.2014.05.009. Epub 2014 Jun 19. PubMed PMID: 24954007; PubMed
Central PMCID: PMC4104156.

2. Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain
Robert P. Law, Stephen J. Atkinson, Paul Bamborough, Chun-wa Chung, Emmanuel H. Demont, Laurie J. Gordon, Matthew Lindon, Rab K. Prinjha, Allan J. B. Watson, and David J. Hirst
Publication Date (Web): April 15, 2018 (Article)
DOI: 10.1021/acs.jmedchem.7b01666