Sulfo-SIA Crosslinker
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 571609

CAS#: NONE

Description: Sulfo-SIA Crosslinker, or N-Sulfosuccinimidyl iodoacetate, is a non-cleavable, heterobifunctional protein crosslinker. Sulfo-SIA is water soluble. Sulfo-SIA Crosslinking Reagent is among the shortest amine and sulfhydryl (thiol) reactive crosslinkers known with a spacer arm length of 1.5 Angstroms. Sulfo-SIA Crosslinker is useful in making antibody drug conjugates (ADCs).

Chemical Structure

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Sulfo-SIA Crosslinker
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 571609
Name: Sulfo-SIA Crosslinker
CAS#: NONE
Chemical Formula: C6H7INO7S
Exact Mass: 363.90
Molecular Weight: 364.087
Elemental Analysis: C, 19.79; H, 1.94; I, 34.86; N, 3.85; O, 30.76; S, 8.81

Price and Availability

Size Price Availability Quantity
100mg USD 275
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Synonym: Sulfo-SIA Crosslinker, Sulfo-SIA Cross linker, Sulfo-SIA Cross-linker

IUPAC/Chemical Name: N-Sulfosuccinimidyl iodoacetate

InChi Key: LBYKLOPOXRATHZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H7INO7S/c7-3-6(11)15-8(16(12,13)14)4(9)1-2-5(8)10/h1-3H2,(H,12,13,14)

SMILES Code: O=C(O[N]1(S(=O)(O)=O)C(CCC1=O)=O)CI

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 364.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Piñero DP, Alio JL, Klonowski P, Toffaha B. Vectorial astigmatic changes after corneal collagen crosslinking in keratoconic corneas previously treated with intracorneal ring segments: a preliminary study. Eur J Ophthalmol. 2012;22 Suppl 7:S69-80. doi: 10.5301/ejo.5000063. PubMed PMID: 22020986.

2: Dosio F, Arpicco S, Adobati E, Canevari S, Brusa P, De Santis R, Parente D, Pignanelli P, Negri DR, Colnaghi MI, Cattel L. Role of cross-linking agents in determining the biochemical and pharmacokinetic properties of Mgr6-clavin immunotoxins. Bioconjug Chem. 1998 May-Jun;9(3):372-81. PubMed PMID: 9576812.

3: Mond JJ, Seghal E, Kung J, Finkelman FD. Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin. J Immunol. 1981 Sep;127(3):881-8. PubMed PMID: 6790620.