WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581197
Description: DAC 5945 is a more potent muscarinic antagonist in the airways than in the heart, demonstrating M3/M2 selectivity in vivo.
MedKoo Cat#: 581197
Name: Dac 5945
Chemical Formula: C19H30ClN3O
Exact Mass: 351.2077
Molecular Weight: 351.92
Elemental Analysis: C, 64.85; H, 8.59; Cl, 10.07; N, 11.94; O, 4.55
This product is not in stock, which may be available by custom synthesis.
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Synonym: Dac 5945;
IUPAC/Chemical Name: N-Iminomethyl-N'-((2-hydroxy-2-phenyl-2-cyclohexyl)ethyl)piperazine hcl
InChi Key: ABECNUXOXSXJCR-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H29N3O.ClH/c20-16-22-13-11-21(12-14-22)15-19(23,17-7-3-1-4-8-17)18-9-5-2-6-10-18;/h1,3-4,7-8,16,18,20,23H,2,5-6,9-15H2;1H
SMILES Code: OC(C1CCCCC1)(C2=CC=CC=C2)CN3CCN(C=N)CC3.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 351.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Howell RE, Laemont KD, Noronha-Blob L. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196(3):323-6. PubMed PMID: 1893917.
2: Howell RE, Kovalsky MP, Laemont KD. Methoctramine induces nonspecific airway hyperresponsiveness in vivo. Eur J Pharmacol. 1994 Nov 14;265(1-2):67-75. PubMed PMID: 7883031.
3: Roffel AF, Hamstra JJ, Elzinga CR, Zaagsma J. Selectivity profile of some recent muscarinic antagonists in bovine and guinea-pig trachea and heart. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):82-98. PubMed PMID: 7893193.