Dac 5945

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 581197

CAS#: 124065-13-0

Description: DAC 5945 is a more potent muscarinic antagonist in the airways than in the heart, demonstrating M3/M2 selectivity in vivo.

Chemical Structure

Dac 5945
CAS# 124065-13-0

Theoretical Analysis

MedKoo Cat#: 581197
Name: Dac 5945
CAS#: 124065-13-0
Chemical Formula: C19H30ClN3O
Exact Mass: 351.2077
Molecular Weight: 351.92
Elemental Analysis: C, 64.85; H, 8.59; Cl, 10.07; N, 11.94; O, 4.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Dac 5945;

IUPAC/Chemical Name: N-Iminomethyl-N'-((2-hydroxy-2-phenyl-2-cyclohexyl)ethyl)piperazine hcl


InChi Code: InChI=1S/C19H29N3O.ClH/c20-16-22-13-11-21(12-14-22)15-19(23,17-7-3-1-4-8-17)18-9-5-2-6-10-18;/h1,3-4,7-8,16,18,20,23H,2,5-6,9-15H2;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 351.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Howell RE, Laemont KD, Noronha-Blob L. Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo. Eur J Pharmacol. 1991 Apr 24;196(3):323-6. PubMed PMID: 1893917.

2: Howell RE, Kovalsky MP, Laemont KD. Methoctramine induces nonspecific airway hyperresponsiveness in vivo. Eur J Pharmacol. 1994 Nov 14;265(1-2):67-75. PubMed PMID: 7883031.

3: Roffel AF, Hamstra JJ, Elzinga CR, Zaagsma J. Selectivity profile of some recent muscarinic antagonists in bovine and guinea-pig trachea and heart. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):82-98. PubMed PMID: 7893193.