AGI-24512

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206967

CAS#: 2201066-53-5

Description: AGI-24512 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-24512 showed in vivo activity in MTAP null tumors.


Chemical Structure

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AGI-24512
CAS# 2201066-53-5

Theoretical Analysis

MedKoo Cat#: 206967
Name: AGI-24512
CAS#: 2201066-53-5
Chemical Formula: C24H24N4O2
Exact Mass: 400.19
Molecular Weight: 400.482
Elemental Analysis: C, 71.98; H, 6.04; N, 13.99; O, 7.99

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AGI-24512; AGI 24512; AGI24512.

IUPAC/Chemical Name: 6-(4-hydroxyphenyl)-5-methyl-2-phenyl-3-(piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

InChi Key: JDHPOXNOROPDTE-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H24N4O2/c1-16-20(17-10-12-19(29)13-11-17)24(30)28-23(25-16)22(27-14-6-3-7-15-27)21(26-28)18-8-4-2-5-9-18/h2,4-5,8-13,25,29H,3,6-7,14-15H2,1H3

SMILES Code: OC(C=C1)=CC=C1C(C(N2N=C(C(N3CCCCC3)=C2N4)C5=CC=CC=C5)=O)=C4C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 400.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Pyrazolo[1,​5-​a]​pyrimidin-​7(4H)​-​ones as inhibitors of cellular metabolic processes and their preparation
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From U.S. Pat. Appl. Publ. (2018), US 20180079753 A1 20180322. | Language: English, Database: CAPLUS

2. Preparation of pyrazolo[1,​5-​a]​pyrimidin-​7(4H)​-​ones as methionine adenosyltransferase 2A inhibitors for treatment of cancer
By Konteatis, Zenon D.; Sui, Zhihua; Travins, Jeremy M.; Ye, Zhixiong
From PCT Int. Appl. (2018), WO 2018045071 A1 20180308. | Language: English, Database: CAPLUS