WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 562574
Description: 2OH-BNPP1 is an inhibitor of the kinase activity of BUB1.
MedKoo Cat#: 562574
Chemical Formula: C16H19N5O
Exact Mass: 297.159
Molecular Weight: 297.36
Elemental Analysis: C, 64.63; H, 6.44; N, 23.55; O, 5.38
Synonym: 2OH-BNPP1; 2OHBNPP1; 2OH BNPP1;
IUPAC/Chemical Name: 2-[(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenol
InChi Key: LWLCFWPPMNPMOI-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H19N5O/c1-16(2,3)21-15-13(14(17)18-9-19-15)11(20-21)8-10-6-4-5-7-12(10)22/h4-7,9,22H,8H2,1-3H3,(H2,17,18,19)
SMILES Code: OC1=CC=CC=C1CC2=NN(C(C)(C)C)C3=NC=NC(N)=C32
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 297.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Nyati S, Schinske-Sebolt K, Pitchiaya S, Chekhovskiy K, Chator A, Chaudhry N, Dosch J, Van Dort ME, Varambally S, Kumar-Sinha C, Nyati MK, Ray D, Walter NG, Yu H, Ross BD, Rehemtulla A. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1. doi: 10.1126/scisignal.2005379. PubMed PMID: 25564677; PubMed Central PMCID: PMC4440544.