2OH-BNPP1
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MedKoo CAT#: 562574

CAS#: 833481-73-5

Description: 2OH-BNPP1 is an inhibitor of the kinase activity of BUB1.


Chemical Structure

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2OH-BNPP1
CAS# 833481-73-5

Theoretical Analysis

MedKoo Cat#: 562574
Name: 2OH-BNPP1
CAS#: 833481-73-5
Chemical Formula: C16H19N5O
Exact Mass: 297.159
Molecular Weight: 297.36
Elemental Analysis: C, 64.63; H, 6.44; N, 23.55; O, 5.38

Price and Availability

Size Price Availability Quantity
5.0mg USD 365.0 2 Weeks
10.0mg USD 605.0 2 Weeks
25.0mg USD 1115.0 2 Weeks
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Synonym: 2OH-BNPP1; 2OHBNPP1; 2OH BNPP1;

IUPAC/Chemical Name: 2-[(4-Amino-1-(tert-butyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)methyl]phenol

InChi Key: LWLCFWPPMNPMOI-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H19N5O/c1-16(2,3)21-15-13(14(17)18-9-19-15)11(20-21)8-10-6-4-5-7-12(10)22/h4-7,9,22H,8H2,1-3H3,(H2,17,18,19)

SMILES Code: OC1=CC=CC=C1CC2=NN(C(C)(C)C)C3=NC=NC(N)=C32

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 297.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Nyati S, Schinske-Sebolt K, Pitchiaya S, Chekhovskiy K, Chator A, Chaudhry N, Dosch J, Van Dort ME, Varambally S, Kumar-Sinha C, Nyati MK, Ray D, Walter NG, Yu H, Ross BD, Rehemtulla A. The kinase activity of the Ser/Thr kinase BUB1 promotes TGF-β signaling. Sci Signal. 2015 Jan 6;8(358):ra1. doi: 10.1126/scisignal.2005379. PubMed PMID: 25564677; PubMed Central PMCID: PMC4440544.