alphaSYN-IN-NAB2
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MedKoo CAT#: 562527

CAS#: 1504588-00-4

Description: alphaSYN-IN-NAB2 is an inhibitor of α-synuclein mutations. It acts by reversing the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons and promoting E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport..


Chemical Structure

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alphaSYN-IN-NAB2
CAS# 1504588-00-4

Theoretical Analysis

MedKoo Cat#: 562527
Name: alphaSYN-IN-NAB2
CAS#: 1504588-00-4
Chemical Formula: C23H20ClN3O
Exact Mass: 389.1295
Molecular Weight: 389.88
Elemental Analysis: C, 70.86; H, 5.17; Cl, 9.09; N, 10.78; O, 4.10

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
25.0mg USD 640.0 2 Weeks
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Synonym: alphaSYN-IN-NAB2; alphaSYN IN NAB2; alphaSYNINNAB2; alphaSYN inhibitor NAB2; alphaSYN inhibitor-NAB2; NAB2; α-Synuclein inhibitor NAB2; αSyn-reversor-NAB2; Rsp5/Nedd4 actovator NAB2; NAB2; NAB 2; NAB-2;

IUPAC/Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide

InChi Key: CZSLEMCYYGEGKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12,14H,13H2,1-2H3,(H,25,28)

SMILES Code: O=C(C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1)NCC4=CC=CC=C4Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 389.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wang L, Hong J, Wu Y, Liu G, Yu W, Chen L. Seipin deficiency in mice causes loss of dopaminergic neurons via aggregation and phosphorylation of α-synuclein and neuroinflammation. Cell Death Dis. 2018 Apr 18;9(5):440. doi: 10.1038/s41419-018-0471-7. PubMed PMID: 29670081.

2: Shvadchak VV, Afitska K, Yushchenko DA. Inhibition of α-Synuclein Amyloid Fibril Elongation by Blocking Fibril Ends. Angew Chem Int Ed Engl. 2018 Mar 25. doi: 10.1002/anie.201801071. [Epub ahead of print] PubMed PMID: 29575453.

3: Sturm E, Fellner L, Krismer F, Poewe W, Wenning GK, Stefanova N. Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy. Neurotherapeutics. 2016 Oct;13(4):871-879. doi: 10.1007/s13311-016-0447-1. PubMed PMID: 27259295; PubMed Central PMCID: PMC5081120.

4: Delenclos M, Trendafilova T, Jones DR, Moussaud S, Baine AM, Yue M, Hirst WD, McLean PJ. A Rapid, Semi-Quantitative Assay to Screen for Modulators of Alpha-Synuclein Oligomerization Ex vivo. Front Neurosci. 2016 Jan 19;9:511. doi: 10.3389/fnins.2015.00511. eCollection 2015. PubMed PMID: 26834539; PubMed Central PMCID: PMC4717311.

5: Elson JL, Yates A, Pienaar IS. Pedunculopontine cell loss and protein aggregation direct microglia activation in parkinsonian rats. Brain Struct Funct. 2016 May;221(4):2319-41. doi: 10.1007/s00429-015-1045-4. Epub 2015 May 20. PubMed PMID: 25989851.

6: Lan D, Wang W, Zhuang J, Zhao Z. Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein. Mol Med Rep. 2015 Mar;11(3):1655-60. doi: 10.3892/mmr.2014.3011. Epub 2014 Nov 27. PubMed PMID: 25434876; PubMed Central PMCID: PMC4270325.

7: Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11. PubMed PMID: 24619358; PubMed Central PMCID: PMC4110482.

8: Harrison IF, Dexter DT. Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease? Pharmacol Ther. 2013 Oct;140(1):34-52. doi: 10.1016/j.pharmthera.2013.05.010. Epub 2013 May 24. Review. PubMed PMID: 23711791.

9: Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy AG. α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci. 2011 Feb 9;31(6):2035-51. doi: 10.1523/JNEUROSCI.5634-10.2011. PubMed PMID: 21307242; PubMed Central PMCID: PMC3041642.

10: Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S. The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation. Biophys J. 2010 Mar 3;98(5):843-51. doi: 10.1016/j.bpj.2009.10.056. PubMed PMID: 20197038; PubMed Central PMCID: PMC2830463.

11: Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57. doi: 10.1124/jpet.109.158436. Epub 2009 Nov 24. PubMed PMID: 19934398; PubMed Central PMCID: PMC2835433.

12: Ubhi K, Lee PH, Adame A, Inglis C, Mante M, Rockenstein E, Stefanova N, Wenning GK, Masliah E. Mitochondrial inhibitor 3-nitroproprionic acid enhances oxidative modification of alpha-synuclein in a transgenic mouse model of multiple system atrophy. J Neurosci Res. 2009 Sep;87(12):2728-39. doi: 10.1002/jnr.22089. PubMed PMID: 19405128; PubMed Central PMCID: PMC2885901.