WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 581185
Description: Dactylarin is cytotoxic antibiotic. Dactylarin isolated from Dactylaria lutea (Deuteromycetes). Cytotoxic effect of dactylarin on Ehrlich ascites carcinoma cells is caused by the inhibition of some SH-dependent glycolytic enzymes, especially of hexokinase (EC 184.108.40.206), glyceraldehyde-3-phosphate dehydrogenase (EC 220.127.116.11) and 6-phosphofructokinase (EC 18.104.22.168). Dactylarin interacts with thiols, which explains its inhibitory effectiveness on the above glycolytic enzymes.
MedKoo Cat#: 581185
Chemical Formula: C16H16O6
Exact Mass: 304.0947
Molecular Weight: 304.3
Elemental Analysis: C, 63.15; H, 5.30; O, 31.55
This product is not in stock, which may be available by custom synthesis.
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Synonym: Dactylarin; Altersolanol B; Dactylarin;
IUPAC/Chemical Name: 3,7-Dihydroxy-2',5-dimethoxy-6'-methylspiro(benzofuran-2(3H),1'-(2,5)cyclohexadien)-4'-one
InChi Key: HRWHMMDDURCHGK-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H16O6/c1-8-4-9(17)5-13(21-3)16(8)15(19)11-6-10(20-2)7-12(18)14(11)22-16/h4-7,15,18-19H,1-3H3
SMILES Code: O=C(C=C1C)C=C(OC)C21OC3=C(O)C=C(OC)C=C3C2O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 304.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sturdík E, Drobnica L. Interaction of cytotoxic antibiotic dactylarin with glycolytic thiol enzymes in Ehrlich ascites carcinoma cells. J Antibiot (Tokyo). 1981 Jun;34(6):708-12. PubMed PMID: 6456251.
2: Henderson JF, Zombor G, Miko M. Adenosine triphosphate catabolism in Ehrlich ascites tumor cells treated with dactylarin. Biochem Pharmacol. 1980 Aug 1;29(15):2155-8. PubMed PMID: 7190827.
3: Miko M, Drobnica L, Chance B. Inhibition of energy metabolism in Ehrlich ascites cells treated with dactylarin in vitro. Cancer Res. 1979 Oct;39(10):4242-51. PubMed PMID: 476657.
4: Becker AM, Rickards RW, Schmalzl KJ, Yick HC. Metabolites of Dactylaria lutea. The structures of dactylariol and the antiprotozoal antibiotic dactylarin. J Antibiot (Tokyo). 1978 Apr;31(4):324-9. PubMed PMID: 566263.
5: Kettner M, Nemec P, Kovác S, Balanová J. Dactylarin, a new antiprotozoal antibiotic from Dactylaria lutea. J Antibiot (Tokyo). 1973 Nov;26(11):692-6. PubMed PMID: 4792118.
6: Horáková K, Navarová J, Nemec P, Kettner M. Effect of dactylarin of HeLa cells. J Antibiot (Tokyo). 1974 Jun;27(6):408-12. PubMed PMID: 4851620.