Swertianolin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341314

CAS#: 23445-00-3

Description: Swertianolin is a biochemical.


Chemical Structure

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Swertianolin
CAS# 23445-00-3

Theoretical Analysis

MedKoo Cat#: 341314
Name: Swertianolin
CAS#: 23445-00-3
Chemical Formula: C20H20O11
Exact Mass: 436.1006
Molecular Weight: 436.369
Elemental Analysis: C, 55.05; H, 4.62; O, 40.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Swertianolin; CCRIS 5474; CCRIS-5474 CCRIS5474.

IUPAC/Chemical Name: Xanthen-9-one, 5,8-dihydroxy-1-(beta-D-glucopyranosyloxy)-3-methoxy-

InChi Key: CYNUMZCJGCZYTD-DIKOWXHZSA-N

InChi Code: InChI=1S/C20H20O11/c1-28-7-4-10-14(16(25)13-8(22)2-3-9(23)19(13)29-10)11(5-7)30-20-18(27)17(26)15(24)12(6-21)31-20/h2-5,12,15,17-18,20-24,26-27H,6H2,1H3/t12-,15-,17+,18-,20-/m1/s1

SMILES Code: O=C1C2=C(OC3=C1C(O)=CC=C3O)C=C(OC)C=C2O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 436.369 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kuang HX, Wu GS, Liu H, Yu Y, Wu Q, Wang QH, Yang BY, Wang ZB. [Isolation and identification of xanthones from Gentianella acuta]. Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(12):2280-2283. doi: 10.4268/cjcmm20161218. Chinese. PubMed PMID: 28901073.

2: Pan Y, Zhang J, Zhao YL, Wang YZ, Jin H. Chemotaxonomic Studies of Nine Gentianaceae Species from Western China Based on Liquid Chromatography Tandem Mass Spectrometry and Fourier Transform Infrared Spectroscopy. Phytochem Anal. 2016 May;27(3-4):158-67. doi: 10.1002/pca.2611. Epub 2016 Feb 26. PubMed PMID: 26919544.

3: Wang Z, Wu Q, Yu Y, Yang C, Jiang H, Wang Q, Yang B, Kuang H. Determination and pharmacokinetic study of four xanthones in rat plasma after oral administration of Gentianella acuta extract by UHPLC-ESI-MS/MS. J Ethnopharmacol. 2015 Nov 4;174:261-9. doi: 10.1016/j.jep.2015.08.023. Epub 2015 Aug 20. PubMed PMID: 26297839.

4: Tian C, Zhang T, Wang L, Shan Q, Jiang L. The hepatoprotective effect and chemical constituents of total iridoids and xanthones extracted from Swertia mussotii Franch. J Ethnopharmacol. 2014 May 28;154(1):259-66. doi: 10.1016/j.jep.2014.04.018. Epub 2014 Apr 16. PubMed PMID: 24746481.

5: He J, Tian C, Ouyang H, Adelakun TA, Yu B, Chang Y, Pan G, Jiang L, Gao X. Determination of swertianolin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomed Chromatogr. 2014 Oct;28(10):1418-22. doi: 10.1002/bmc.3184. Epub 2014 Mar 28. PubMed PMID: 24687287.

6: Wani BA, Ramamoorthy D, Rather MA, Arumugam N, Qazi AK, Majeed R, Hamid A, Ganie SA, Ganai BA, Anand R, Gupta AP. Induction of apoptosis in human pancreatic MiaPaCa-2 cells through the loss of mitochondrial membrane potential (ΔΨm) by Gentiana kurroo root extract and LC-ESI-MS analysis of its principal constituents. Phytomedicine. 2013 Jun 15;20(8-9):723-33. doi: 10.1016/j.phymed.2013.01.011. Epub 2013 Mar 1. PubMed PMID: 23453831.

7: Singh PP, Ambika, Chauhan SM. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26(18):1682-6. doi: 10.1080/14786419.2011.592836. Epub 2011 Oct 10. PubMed PMID: 21985644.

8: Wang H, Geng C, Zhang X, Ma Y, Jiang Z, Chen J. [Chemical constituents of Swertia macrosperma]. Zhongguo Zhong Yao Za Zhi. 2010 Dec;35(23):3161-4. Chinese. PubMed PMID: 21355239.

9: Xu K, Shen J, Li F, Liu J, Liu G, Tan J, Tan G. [Determination of six active components in three species of genus Swertia by HPLC multiwavelength with detection]. Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1384-9. Chinese. PubMed PMID: 19771868.

10: Urbain A, Marston A, Grilo LS, Bravo J, Purev O, Purevsuren B, Batsuren D, Reist M, Carrupt PA, Hostettmann K. Xanthones from Gentianella amarella ssp. acuta with acetylcholinesterase and monoamine oxidase inhibitory activities. J Nat Prod. 2008 May;71(5):895-7. doi: 10.1021/np070690l. Epub 2008 Mar 13. PubMed PMID: 18336006.

11: Bao Y, Ji WH, Ma YH, Ji LJ. [Simultaneous determination of six main constituents in Swertia of Qinghai Province and Sichuan Province by HPLC]. Zhongguo Zhong Yao Za Zhi. 2006 Dec;31(24):2036-8. Chinese. PubMed PMID: 17357549.

12: Qing Z, Jiachun C, Yanwen L. [Study on chemical constituents from Swertia kauitchensis Franch]. Zhong Yao Cai. 2004 Dec;27(12):908-10. Chinese. PubMed PMID: 15807240.

13: Urbain A, Marston A, Queiroz EF, Ndjoko K, Hostettmann K. Xanthones from Gentiana campestris as new acetylcholinesterase inhibitors. Planta Med. 2004 Oct;70(10):1011-4. PubMed PMID: 15490334.

14: Menković N, Savikin-Fodulović K, Bulatović V, Aljancić I, Juranić N, Macura S, Vajs V, Milosavljević S. Xanthones from Swertia punctata. Phytochemistry. 2002 Oct;61(4):415-20. PubMed PMID: 12377236.

15: Matsushima T, Araki A, Yagame O, Muramatsu M, Koyama K, Ohsawa K, Natori S, Tomimori H. Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Mutat Res. 1985 Jun-Jul;150(1-2):141-6. PubMed PMID: 3889613.