Alpha-Chloralose
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 330130

CAS#: 15879-93-3

Description: Alpha-Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.


Chemical Structure

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Alpha-Chloralose
CAS# 15879-93-3

Theoretical Analysis

MedKoo Cat#: 330130
Name: Alpha-Chloralose
CAS#: 15879-93-3
Chemical Formula: C8H11Cl3O6
Exact Mass: 307.9621
Molecular Weight: 309.52
Elemental Analysis: C, 31.04; H, 3.58; Cl, 34.36; O, 31.01

Price and Availability

Size Price Availability Quantity
25.0g USD 250.0 2 Weeks
50.0g USD 350.0 2 Weeks
100.0g USD 450.0 2 Weeks
200.0g USD 650.0 2 Weeks
500.0g USD 950.0 2 Weeks
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Synonym: Alpha-Chloralose; Anhydro-D-glucochloral,

IUPAC/Chemical Name: (1R)-1-((3aR,5R,6S,6aR)-6-hydroxy-2-(trichloromethyl)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol

InChi Key: OJYGBLRPYBAHRT-ZMKYHYQQSA-N

InChi Code: InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7?/m1/s1

SMILES Code: O[C@@H]([C@@H]([C@@H](CO)O)O1)[C@@H](O2)[C@H]1OC2C(Cl)(Cl)Cl

Appearance: Solid powder

Purity: 98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 309.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Low LA, Bauer LC, Klaunberg BA. Comparing the Effects of Isoflurane and Alpha Chloralose upon Mouse Physiology. PLoS One. 2016 May 5;11(5):e0154936. doi: 10.1371/journal.pone.0154936. eCollection 2016. PubMed PMID: 27148970; PubMed Central PMCID: PMC4858227.

2: Leporati M, Salomone A, Golè G, Vincenti M. Determination of Anticoagulant Rodenticides and α-Chloralose in Human Hair. Application to a Real Case. J Anal Toxicol. 2016 May;40(4):277-85. doi: 10.1093/jat/bkw019. Epub 2016 Mar 16. PubMed PMID: 26984200.

3: Beam DM, Neto-Neves EM, Stubblefield WB, Alves NJ, Tune JD, Kline JA. Comparison of isoflurane and α-chloralose in an anesthetized swine model of acute pulmonary embolism producing right ventricular dysfunction. Comp Med. 2015 Feb;65(1):54-61. PubMed PMID: 25730758; PubMed Central PMCID: PMC4396930.

4: Hartup BK, Schneider L, Engels JM, Hayes MA, Barzen JA. Capture of sandhill cranes using alpha-chloralose: a 10-year follow-up. J Wildl Dis. 2014 Jan;50(1):143-5. doi: 10.7589/2013-06-140. Epub 2013 Oct 25. PubMed PMID: 24171579.

5: Kullmann FA, Wells GI, Langdale CL, Zheng J, Thor KB. Stability of the acetic acid-induced bladder irritation model in alpha chloralose-anesthetized female cats. PLoS One. 2013 Sep 9;8(9):e73771. doi: 10.1371/journal.pone.0073771. eCollection 2013. PubMed PMID: 24040064; PubMed Central PMCID: PMC3767621.

6: Matsuura T, Iwata S, Shin MC, Wakita M, Ogawa SK, Akaike N. Different effects of α-chloralose on spontaneous and evoked GABA release in rat hippocampal CA1 neurons. Brain Res Bull. 2011 May 30;85(3-4):180-8. doi: 10.1016/j.brainresbull.2011.03.022. Epub 2011 Mar 29. PubMed PMID: 21453759.

7: Alonso Bde C, Makarova T, Hess A. On the use of α-chloralose for repeated BOLD fMRI measurements in rats. J Neurosci Methods. 2011 Feb 15;195(2):236-40. doi: 10.1016/j.jneumeth.2010.12.010. Epub 2010 Dec 14. PubMed PMID: 21163302.

8: Williams KA, Magnuson M, Majeed W, LaConte SM, Peltier SJ, Hu X, Keilholz SD. Comparison of alpha-chloralose, medetomidine and isoflurane anesthesia for functional connectivity mapping in the rat. Magn Reson Imaging. 2010 Sep;28(7):995-1003. doi: 10.1016/j.mri.2010.03.007. Epub 2010 Apr 24. PubMed PMID: 20456892; PubMed Central PMCID: PMC3740561.

9: Tsurugizawa T, Uematsu A, Uneyama H, Torii K. Effects of isoflurane and alpha-chloralose anesthesia on BOLD fMRI responses to ingested L-glutamate in rats. Neuroscience. 2010 Jan 13;165(1):244-51. doi: 10.1016/j.neuroscience.2009.10.006. Epub 2009 Oct 9. PubMed PMID: 19819307.

10: Kufahl PR, Pentkowski NS, Heintzelman K, Neisewander JL. Cocaine-induced Fos expression is detectable in the frontal cortex and striatum of rats under isoflurane but not alpha-chloralose anesthesia: implications for FMRI. J Neurosci Methods. 2009 Jul 30;181(2):241-8. doi: 10.1016/j.jneumeth.2009.05.012. Epub 2009 May 23. PubMed PMID: 19467261; PubMed Central PMCID: PMC2748745.

11: Sommers MG, van Egmond J, Booij LH, Heerschap A. Isoflurane anesthesia is a valuable alternative for alpha-chloralose anesthesia in the forepaw stimulation model in rats. NMR Biomed. 2009 May;22(4):414-8. doi: 10.1002/nbm.1351. PubMed PMID: 19003937.

12: Wang K, Zheng C, Wu C, Gao M, Liu Q, Yang K, Ellsworth K, Xu L, Wu J. alpha-Chloralose diminishes gamma oscillations in rat hippocampal slices. Neurosci Lett. 2008 Aug 15;441(1):66-71. doi: 10.1016/j.neulet.2008.06.014. Epub 2008 Jun 8. PubMed PMID: 18597935.

13: Aburto-Luna V, Meza-León RL, Bernès S. (R)-3,4,5-Tride-oxy-5,6-didehydro-1,2-O-(2,2,2-trichloro-ethyl-idene)-α-d-gluco-f uran-ose-6,3-carbolactone: a new derivative of α-chloralose. Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 20;64(Pt 9):o1784. doi: 10.1107/S1600536808026196. PubMed PMID: 21201764; PubMed Central PMCID: PMC2960566.

14: Luckl J, Keating J, Greenberg JH. Alpha-chloralose is a suitable anesthetic for chronic focal cerebral ischemia studies in the rat: a comparative study. Brain Res. 2008 Jan 29;1191:157-67. Epub 2007 Nov 28. PubMed PMID: 18096143; PubMed Central PMCID: PMC2266075.

15: Shih YY, Chen YY, Chen JM, Lung Y, Chen JY, Chang C, Chen JC, Jaw FS. Exploring nociceptive response by BOLD fMRI in alpha-chloralose anesthetized rats. Conf Proc IEEE Eng Med Biol Soc. 2006;1:33-6. PubMed PMID: 17946376.

16: Lawrence J, Stroman PW, Malisza KL. Functional MRI of the cervical spinal cord during noxious and innocuous thermal stimulation in the alpha-chloralose- and halothane-anesthetized rat. Magn Reson Imaging. 2008 Jan;26(1):1-10. Epub 2007 Jun 22. PubMed PMID: 17587529.

17: Lawrence J, Stroman PW, Malisza KL. Comparison of functional activity in the rat cervical spinal cord during alpha-chloralose and halothane anesthesia. Neuroimage. 2007 Feb 15;34(4):1665-72. Epub 2007 Jan 3. PubMed PMID: 17204434.

18: Yang J, Shen J. Increased oxygen consumption in the somatosensory cortex of alpha-chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 Tesla. Neuroimage. 2006 Sep;32(3):1317-25. Epub 2006 Jun 21. PubMed PMID: 16797191.

19: Segev G, Yas-Natan E, Shlosberg A, Aroch I. Alpha-chloralose poisoning in dogs and cats: a retrospective study of 33 canine and 13 feline confirmed cases. Vet J. 2006 Jul;172(1):109-13. PubMed PMID: 16772135.

20: Xu S, Yang J, Li CQ, Zhu W, Shen J. Metabolic alterations in focally activated primary somatosensory cortex of alpha-chloralose-anesthetized rats measured by 1H MRS at 11.7 T. Neuroimage. 2005 Nov 1;28(2):401-9. Epub 2005 Sep 22. PubMed PMID: 16182571.