RI-1
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MedKoo CAT#: 407511

CAS#: 415713-60-9

Description: RI-1 is an irreversible inhibitor of RAD51 (IC50s = 5-30 µM), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI-1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into filaments on DNA. RI-1 holds promise as an oncologic drug. Furthermore, RI-1 represents a unique tool to dissect the network of reaction pathways that contribute to DNA repair in cells.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 150 2 Weeks
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2450 2 Weeks
2g USD 3850 2 Weeks
5g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

RI-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407511
Name: RI-1
CAS#: 415713-60-9
Chemical Formula: C14H11Cl3N2O3
Exact Mass: 359.9835
Molecular Weight: 361.603
Elemental Analysis: C, 46.50; H, 3.07; Cl, 29.41; N, 7.75; O, 13.27


Synonym: RI-1; RI1; RI 1.

IUPAC/Chemical Name: 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione

InChi Key: MWSUIZKGNWELRF-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11Cl3N2O3/c15-9-2-1-8(7-10(9)16)19-13(20)11(17)12(14(19)21)18-3-5-22-6-4-18/h1-2,7H,3-6H2

SMILES Code: O=C(C(Cl)=C1N2CCOCC2)N(C3=CC=C(Cl)C(Cl)=C3)C1=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL,
Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of
RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res.
2012 Aug;40(15):7347-57. doi: 10.1093/nar/gks353. Epub 2012 May 9. PubMed PMID:
22573178; PubMed Central PMCID: PMC3424541.

2: Golec P, Wiczk A, Majchrzyk A, Łoś JM, Węgrzyn G, Łoś M. A role for accessory
genes rI.-1 and rI.1 in the regulation of lysis inhibition by bacteriophage T4.
Virus Genes. 2010 Dec;41(3):459-68. doi: 10.1007/s11262-010-0532-1. Epub 2010 Oct
14. PubMed PMID: 20945083; PubMed Central PMCID: PMC2962797.

3: Bartmann P, Bamberger U, Pohlandt F, Gortner L. Immunogenicity and
immunomodulatory activity of bovine surfactant (SF-RI 1). Acta Paediatr. 1992
May;81(5):383-8. PubMed PMID: 1498502.