Yoda1
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MedKoo CAT#: 562426

CAS#: 448947-81-7

Description: Yoda1, also known as GlyT2-IN-1, is an agonist of the mechanotransduction channel Piezo1. It acts by eliciting Ca2+ flux in Piezo1- but not vector-transfected cells.


Chemical Structure

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Yoda1
CAS# 448947-81-7

Theoretical Analysis

MedKoo Cat#: 562426
Name: Yoda1
CAS#: 448947-81-7
Chemical Formula: C13H8Cl2N4S2
Exact Mass: 353.9567
Molecular Weight: 355.25
Elemental Analysis: C, 43.95; H, 2.27; Cl, 19.96; N, 15.77; S, 18.05

Price and Availability

Size Price Availability Quantity
10.0mg USD 90.0 Same day
25.0mg USD 150.0 Same day
50.0mg USD 250.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1650.0 Same day
1.0g USD 2950.0 Same day
2.0g USD 5250.0 Same day
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Related CAS #: 448947-81-7  

Synonym: Yoda1; Yoda-1; Yoda 1; GlyT2-IN-1; GlyT2-IN 1; GlyT2-IN1;

IUPAC/Chemical Name: 2-[5-(2,6-Dichloro-benzylsulfanyl)-[1,3,4]thiadiazol-2-yl]-pyrazine

InChi Key: BQNXBSYSQXSXPT-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H8Cl2N4S2/c14-9-2-1-3-10(15)8(9)7-20-13-19-18-12(21-13)11-6-16-4-5-17-11/h1-6H,7H2

SMILES Code: ClC1=C(C(Cl)=CC=C1)CSC2=NN=C(C3=NC=CN=C3)S2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 355.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R, Beech DJ. Yoda1 analogue (Dooku1) which antagonises Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 Mar 2. doi: 10.1111/bph.14188. [Epub ahead of print] PubMed PMID: 29498036.

2: Dela Paz NG, Frangos JA. Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. doi: 10.1016/j.bbrc.2018.02.058. Epub 2018 Feb 8. PubMed PMID: 29428723; PubMed Central PMCID: PMC5835220.

3: Sugimoto A, Miyazaki A, Kawarabayashi K, Shono M, Akazawa Y, Hasegawa T, Ueda-Yamaguchi K, Kitamura T, Yoshizaki K, Fukumoto S, Iwamoto T. Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells. Sci Rep. 2017 Dec 18;7(1):17696. doi: 10.1038/s41598-017-18089-0. PubMed PMID: 29255201; PubMed Central PMCID: PMC5735093.

4: Beech DJ. Endothelial Piezo1 channels as sensors of exercise. J Physiol. 2018 Mar 15;596(6):979-984. doi: 10.1113/JP274396. Epub 2018 Jan 9. PubMed PMID: 29194632; PubMed Central PMCID: PMC5851887.

5: Gnanasambandam R, Gottlieb PA, Sachs F. The Kinetics and the Permeation Properties of Piezo Channels. Curr Top Membr. 2017;79:275-307. doi: 10.1016/bs.ctm.2016.11.004. Epub 2017 Jan 11. Review. PubMed PMID: 28728821.

6: Ilkan Z, Wright JR, Goodall AH, Gibbins JM, Jones CI, Mahaut-Smith MP. Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line. J Biol Chem. 2017 Jun 2;292(22):9204-9217. doi: 10.1074/jbc.M116.766196. Epub 2017 Apr 17. PubMed PMID: 28416610; PubMed Central PMCID: PMC5454102.

7: Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016 Dec 1;126(12):4527-4536. doi: 10.1172/JCI87343. Epub 2016 Oct 31. PubMed PMID: 27797339; PubMed Central PMCID: PMC5127677.

8: Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A. Chemical activation of the mechanotransduction channel Piezo1. Elife. 2015 May 22;4. doi: 10.7554/eLife.07369. PubMed PMID: 26001275; PubMed Central PMCID: PMC4456433.

9: Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A. Piezo1 links mechanical forces to red blood cell volume. Elife. 2015 May 22;4. doi: 10.7554/eLife.07370. PubMed PMID: 26001274; PubMed Central PMCID: PMC4456639.

Yoda1

10.0mg / USD 90.0