UCF-101
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MedKoo CAT#: 562425

CAS#: 313649-08-0

Description: UCF-101 is a selective inhibitor of the pro-apoptotic mitochondrial serine protease Omi/HtrA2 involved in the cellular response to thermal and oxidative stress.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 220 2 Weeks
10mg USD 350 2 Weeks
25mg USD 670 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

UCF-101, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 562425
Name: UCF-101
CAS#: 313649-08-0
Chemical Formula: C27H17N3O5S
Exact Mass: 495.0889
Molecular Weight: 495.5
Elemental Analysis: C, 65.45; H, 3.46; N, 8.48; O, 16.14; S, 6.47


Synonym: UCF-101; UCF 101; UCF101;

IUPAC/Chemical Name: Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione

InChi Key: NVNSXBXKNMWKEJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H

SMILES Code: O=C(/C(C(N1C2=CC=CC=C2)=O)=C/C3=CC=C(C4=CC=CC=C4[N+]([O-])=O)O3)N(C5=CC=CC=C5)C1=S


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Panda P, Srinivasa N. Learning to Recognize Actions From Limited Training Examples Using a Recurrent Spiking Neural Model. Front Neurosci. 2018 Mar 2;12:126. doi: 10.3389/fnins.2018.00126. eCollection 2018. PubMed PMID: 29551962; PubMed Central PMCID: PMC5840233.

2: Zhu H, Vial R, Lu S, Peng X, Fu H, Tian Y, Cao X. YoTube: Searching Action Proposal Via Recurrent and Static Regression Networks. IEEE Trans Image Process. 2018 Jun;27(6):2609-2622. doi: 10.1109/TIP.2018.2806279. PubMed PMID: 29533898.

3: Zhang L, Li Y, Li X, Zhang Q, Qiu S, Zhang Q, Wang M, Xing H, Rao Q, Tian Z, Tang K, Wang J, Mi Y. Regulation of HtrA2 on WT1 gene expression under imatinib stimulation and its effects on the cell biology of K562 cells. Oncol Lett. 2017 Sep;14(3):3862-3868. doi: 10.3892/ol.2017.6628. Epub 2017 Jul 20. PubMed PMID: 28927158; PubMed Central PMCID: PMC5587996.

4: Liu X, Lei J, Wang K, Ma L, Liu D, Du Y, Wu Y, Zhang S, Wang W, Ma X, Liu H. Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart. Rejuvenation Res. 2017 Jun;20(3):183-192. doi: 10.1089/rej.2016.1861. Epub 2017 Jan 27. PubMed PMID: 27998213.

5: Wang K, Yuan Y, Liu X, Lau WB, Zuo L, Wang X, Ma L, Jiao K, Shang J, Wang W, Ma X, Liu H. Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction. Sci Rep. 2016 Dec 7;6:37927. doi: 10.1038/srep37927. PubMed PMID: 27924873; PubMed Central PMCID: PMC5141441.

6: Su D, Ma J, Zhang Z, Tian Y, Shen B. Protective Effects of UCF-101 on Cerebral Ischemia-Reperfusion (CIR) is Depended on the MAPK/p38/ERK Signaling Pathway. Cell Mol Neurobiol. 2016 Aug;36(6):907-14. doi: 10.1007/s10571-015-0275-6. Epub 2015 Oct 1. PubMed PMID: 26429193.

7: Wu JY, Li M, Cao LJ, Sun ML, Chen D, Ren HG, Xia Q, Tao ZT, Qin ZH, Hu QS, Wang GH. Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO mice. Acta Pharmacol Sin. 2015 Sep;36(9):1043-52. doi: 10.1038/aps.2015.50. Epub 2015 Aug 24. PubMed PMID: 26299953; PubMed Central PMCID: PMC4561969.

8: Ma Q, Hu QS, Xu RJ, Zhen XC, Wang GH. Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1. Acta Pharmacol Sin. 2015 Aug;36(8):966-75. doi: 10.1038/aps.2015.48. PubMed PMID: 26238290; PubMed Central PMCID: PMC4564885.

9: Jain S, Keys D, Ljubanovic D, Edelstein CL, Jani A. Protection Against Cold Storage-Induced Renal Tubular Cell Apoptosis. Transplantation. 2015 Nov;99(11):2311-6. doi: 10.1097/TP.0000000000000774. PubMed PMID: 26177086; PubMed Central PMCID: PMC4618769.

10: Reigada D, Nieto-Díaz M, Navarro-Ruiz R, Caballero-López MJ, Del Águila A, Muñoz-Galdeano T, Maza RM. Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury. Neuroscience. 2015 Aug 6;300:404-17. doi: 10.1016/j.neuroscience.2015.05.036. Epub 2015 May 22. PubMed PMID: 26004679.

11: Lucotte B, Tajhizi M, Alkhatib D, Samuelsson EB, Wiehager B, Schedin-Weiss S, Sundström E, Winblad B, Tjernberg LO, Behbahani H. Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells. Mol Neurobiol. 2015 Dec;52(3):1077-1092. doi: 10.1007/s12035-014-8906-3. Epub 2014 Oct 8. PubMed PMID: 25288153.

12: Jiang JK, Ma X, Wu QY, Qian WB, Wang N, Shi SS, Han JL, Zhao JY, Jiang SY, Wan CH. Upregulation of mitochondrial protease HtrA2/Omi contributes to manganese-induced neuronal apoptosis in rat brain striatum. Neuroscience. 2014 May 30;268:169-79. doi: 10.1016/j.neuroscience.2014.03.003. Epub 2014 Mar 19. PubMed PMID: 24657776.

13: Hu Y, Huang M, Wang P, Xu Q, Zhang B. Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat. Int Immunopharmacol. 2013 May;16(1):108-13. doi: 10.1016/j.intimp.2013.03.019. Epub 2013 Apr 2. PubMed PMID: 23557966.

14: Wang K, Zhang J, Liu J, Tian J, Wu Y, Wang X, Quan L, Xu H, Wang W, Liu H. Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury. Age (Dordr). 2013 Jun;35(3):733-46. doi: 10.1007/s11357-012-9406-x. Epub 2012 Apr 26. PubMed PMID: 22535253; PubMed Central PMCID: PMC3636415.

15: Hua B, Dong WB, Li QP, Feng ZQ, Yu H, Zhai XS, Lei XP. [Effects of Ucf-101 on expression of Omi/HtrA2 in kidneys of postasphyxial neonatal rats]. Zhongguo Dang Dai Er Ke Za Zhi. 2010 Aug;12(8):658-61. Chinese. PubMed PMID: 20704803.

16: Kim J, Kim DS, Park MJ, Cho HJ, Zervos AS, Bonventre JV, Park KM. Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2010 Jun;298(6):F1332-40. doi: 10.1152/ajprenal.00737.2009. Epub 2010 Mar 10. PubMed PMID: 20219823; PubMed Central PMCID: PMC2886814.

17: Liu QB, Liu LL, Lu YM, Tao RR, Huang JY, Han F, Lou YJ. The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells. Toxicol Appl Pharmacol. 2010 May 1;244(3):374-84. doi: 10.1016/j.taap.2010.02.004. Epub 2010 Feb 11. Erratum in: Toxicol Appl Pharmacol. 2010 Aug 15;247(1):70. Shioda, Norifumi [removed]; Moriguchi, Shigeki [removed]; Fukunaga, Kohji [removed]. PubMed PMID: 20153346.

18: Li Q, Li J, Ren J. UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK. Am J Physiol Endocrinol Metab. 2009 Oct;297(4):E965-73. doi: 10.1152/ajpendo.00323.2009. Epub 2009 Aug 18. PubMed PMID: 19690068; PubMed Central PMCID: PMC2763789.

19: Zhang Y, Dong WB, Li QP, Deng CL, Xiong T, Lei XP, Guo L. [Role of Omi/HtrA2 in renal tubular cells apoptosis induced by post asphyxial serum of neonate]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009 Jun;21(6):346-8. Chinese. PubMed PMID: 19570340.

20: Li Q, Hueckstaedt LK, Ren J. The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase. Exp Physiol. 2009 Sep;94(9):984-94. doi: 10.1113/expphysiol.2009.049189. Epub 2009 Jun 26. Erratum in: Exp Physiol. 2016 Mar 1;101(3):451. PubMed PMID: 19561140; PubMed Central PMCID: PMC2864042.