WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 562420

CAS#: 956958-53-5

Description: XL147-II is an ATP-competitive inhibitor of class I PI3K isoforms. It acts by abrogating Akt and S6 phosphorylation in HER2+ cells and also inducing the expression and phosphorylation of HER3 and other RTKs.

Chemical Structure

CAS# 956958-53-5

Theoretical Analysis

MedKoo Cat#: 562420
Name: XL147-II
CAS#: 956958-53-5
Chemical Formula: C21H16N6O2S2
Exact Mass: 448.0776
Molecular Weight: 448.51
Elemental Analysis: C, 56.24; H, 3.60; N, 18.74; O, 7.13; S, 14.30

Price and Availability

Size Price Availability Quantity
5.0mg USD 250.0 2 Weeks
10.0mg USD 410.0 2 Weeks
25.0mg USD 830.0 2 Weeks
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Synonym: XL147-II; XL147 II; XL147II; XL147 derivative II; XL147derivativeII; XL147-derivative-II;

IUPAC/Chemical Name: N-[3-(2,1,3-Benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methyl-benzenesulfonamide


InChi Code: InChI=1S/C21H16N6O2S2/c1-13-6-9-15(10-7-13)31(28,29)27-21-20(23-16-4-2-3-5-17(16)24-21)22-14-8-11-18-19(12-14)26-30-25-18/h2-12H,1H3,(H,22,23)(H,24,27)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 448.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Akinleye A, Avvaru P, Furqan M, Song Y, Liu D. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol. 2013 Nov 22;6(1):88. doi: 10.1186/1756-8722-6-88. Review. PubMed PMID: 24261963; PubMed Central PMCID: PMC3843585.