WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558214

CAS#: 41928-02-3

Description: 10-Hydroxyyohimbine is a hydroxylated metabolite of yohimbine, a α2-adrenergic receptor antagonist most often used in reversing sedation of dogs and deer.

Chemical Structure

CAS# 41928-02-3

Theoretical Analysis

MedKoo Cat#: 558214
Name: 10-Hydroxyyohimbine
CAS#: 41928-02-3
Chemical Formula: C21H26N2O4
Exact Mass: 370.19
Molecular Weight: 370.449
Elemental Analysis: C, 68.09; H, 7.07; N, 7.56; O, 17.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 10-Hydroxyyohimbine, Yohimbine, quebrachine

IUPAC/Chemical Name: methyl (1S,15R,18S,19R,20S)-7,18-dihydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate


InChi Code: InChI=1S/C21H26N2O4/c1-27-21(26)19-14-9-17-20-13(15-8-12(24)3-4-16(15)22-20)6-7-23(17)10-11(14)2-5-18(19)25/h3-4,8,11,14,17-19,22,24-25H,2,5-7,9-10H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 370.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Duflos A, Redoules F, Fahy J, Jacquesy JC, Jouannetaud MP. Hydroxylation of yohimbine in superacidic media: one-step access to human metabolites 10 and 11-hydroxyyohimbine. J Nat Prod. 2001 Feb;64(2):193-5. PubMed PMID: 11429998.

2: Berlan M, Le Verge R, Galitzky J, Le Corre P. Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine. Br J Pharmacol. 1993 Apr;108(4):927-32. PubMed PMID: 8097957; PubMed Central PMCID: PMC1908160.

3: MEYERS E, PAN SC. Microbial transformation of Rauwolfia alkaloids. II. 10-Hydroxyyohimbine. J Bacteriol. 1961 Mar;81:504-5. PubMed PMID: 13770059; PubMed Central PMCID: PMC279038.