Tyrphostin AG 1112
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 341203

CAS#: 153150-84-6

Description: Tyrphostin AG 1112 is a Bcr-Abl kinase blocker that can activate the terminal differentiation of K562 cells and the purging of Ph+ cells.


Chemical Structure

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Tyrphostin AG 1112
CAS# 153150-84-6

Theoretical Analysis

MedKoo Cat#: 341203
Name: Tyrphostin AG 1112
CAS#: 153150-84-6
Chemical Formula: C15H10N6
Exact Mass: 274.0967
Molecular Weight: 274.287
Elemental Analysis: C, 65.68; H, 3.67; N, 30.64

Price and Availability

Size Price Availability Quantity
1.0mg USD 285.0 2 Weeks
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Synonym: Tyrphostin AG 1112; Tyrphostin AG-1112; Tyrphostin AG1112.

IUPAC/Chemical Name: 1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-alpha-(1H-indol-3-ylmethylene), (Z)-

InChi Key: UATHROQEHSKMCY-KPBXGNTFSA-N

InChi Code: InChI=1S/C15H10N6/c16-6-9(14-12(7-17)15(18)21-20-14)5-10-8-19-13-4-2-1-3-11(10)13/h1-5,8,19,21H,18H2/b10-5+,14-9-

SMILES Code: c1cccc2c1[nH]cc2\C=C(/C#N)c1n[nH]c(c1C#N)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 274.287 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kang TB, Huang C, Liang NC. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. PubMed PMID: 10072895.

2: Anafi M, Gazit A, Zehavi A, Ben-Neriah Y, Levitzki A. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. PubMed PMID: 7505115.