WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407898
Description: Y02224 is a BET inhibitor which exhibited reasonable antiproliferative effect on leukemia cells.
MedKoo Cat#: 407898
Chemical Formula: C20H17BrN2O4S
Exact Mass: 460.0092
Molecular Weight: 461.33
Elemental Analysis: C, 52.07; H, 3.71; Br, 17.32; N, 6.07; O, 13.87; S, 6.95
Y02224 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: Y02224; Y-02224; Y 02224.
IUPAC/Chemical Name: 5-bromo-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-2-methoxybenzenesulfonamide
InChi Key: JTOXINSTQFVILZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H17BrN2O4S/c1-3-23-16-9-8-15(13-5-4-6-14(19(13)16)20(23)24)22-28(25,26)18-11-12(21)7-10-17(18)27-2/h4-11,22H,3H2,1-2H3
SMILES Code: O=C1C2=C(C(N1CC)=CC=C3NS(C4=C(OC)C=CC(Br)=C4)(=O)=O)C3=CC=C2
The following data is based on the product molecular weight 461.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Xue, X. Q.; Zhang, Y.; Liu, Z. X.; Song, M.; Xing, Y. L.; Xiang,
Q. P.; Wang, Z.; Tu, Z. C.; Zhou, Y. L.; Ding, K.; Xu, Y. Discovery of
benzo[cd]indol-2(1H)-ones as potent and specific BET bromodomain
inhibitors: structure-based virtual screening, optimization