WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407895
CAS#: 1832671-96-1
Description: Y06036 is a potent BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). Y06036 bounds to the BRD4(1) bromodomain with Kd values of 82 nM. Y06036 also exhibited high selectivity over other non-BET subfamily members. Y06036 potently inhibited cell growth, colony formation, and the expression of AR, AR regulated genes, and MYC in prostate cancer cell lines. Y06036 also demonstrated therapeutic effects in a C4-2B CRPC xenograft tumor model in mice.
MedKoo Cat#: 407895
Name: Y06036
CAS#: 1832671-96-1
Chemical Formula: C16H15BrN2O5S
Exact Mass: 425.9885
Molecular Weight: 427.269
Elemental Analysis: C, 44.98; H, 3.54; Br, 18.70; N, 6.56; O, 18.72; S, 7.50
Synonym: Y06036; Y-06036; Y 06036.
IUPAC/Chemical Name: 5-Bromo-2-methoxy-N-(6-methoxy-3-methylbenzo[d]-isoxazol-5-yl)benzenesulfonamide
InChi Key: KVGNGFGTOSOVPB-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15BrN2O5S/c1-9-11-7-12(15(23-3)8-14(11)24-18-9)19-25(20,21)16-6-10(17)4-5-13(16)22-2/h4-8,19H,1-3H3
SMILES Code: O=S(C1=CC(Br)=CC=C1OC)(NC2=C(OC)C=C(ON=C3C)C3=C2)=O
1: Zhang M, Zhang Y, Song M, Xue X, Wang J, Wang C, Zhang C, Li C, Xiang Q, Zou
L, Wu X, Wu C, Dong B, Xue W, Zhou Y, Chen H, Wu D, Ding K, Xu Y. Structure-Based
Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and
Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate
Cancer (CRPC). J Med Chem. 2018 Mar 22. doi: 10.1021/acs.jmedchem.8b00103. [Epub
ahead of print] PubMed PMID: 29566488.